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Journal of Cardiovascular Development and Disease, Volume 12, Issue 8

August 2025 - 42 articles

Cover Story: Epicardial radiofrequency ablation is often required when ventricular tachyarrhythmias originate from epicardial or subepicardial substrates that cannot be effectively ablated endocardially. Irrigated-tip catheters are commonly used for such procedures. Unlike endocardial ablation, where the irrigation fluid is mixed with and drained by the bloodstream, the irrigation fluid used in epicardial procedures accumulates within the pericardial space, which causes the sac to expand, requiring manual drainage multiple times throughout the procedure. Our computer simulations show that the accumulation of intrapericardial fluid plays a critical role: While it may offer some thermal protection to adjacent structures, it substantially reduces energy transmission to the myocardium, compromising lesion formation. View this paper
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Articles (42)

  • Review
  • Open Access
1 Citations
1,535 Views
11 Pages

Atrioventricular Node Dysfunction in Heart Failure: New Horizons from Pathophysiology to Therapeutic Perspectives

  • Isabella Fumarulo,
  • Elia Nunzio Maria Salerno,
  • Andrea De Prisco,
  • Salvatore Emanuele Ravenna,
  • Maria Chiara Grimaldi,
  • Francesco Burzotta and
  • Nadia Aspromonte

Heart failure (HF) is characterized by adverse myocardial remodeling involving both the contractile cardiomyocytes and the conduction tissue. HF is often associated with atrioventricular (AV) node dysfunction, which frequently leads to conduction del...

  • Article
  • Open Access
1,187 Views
15 Pages

Comparison of Surgical Treatment Outcomes in Patients with Symptomatic Severe Aortic Valve Stenosis Using the Perceval Sutureless Bioprosthesis Versus a Conventional Biological Valve

  • Dejan M. Lazović,
  • Milica Karadžić,
  • Filip Vučićević,
  • Gorica Marić,
  • Miloš Grujić,
  • Ivana Đurošev,
  • Mladen J. Kočica,
  • Svetozar Putnik and
  • Dragan Cvetković

Objectives: This single-center retrospective comparative cohort study aimed to compare the outcomes of aortic valve replacement using a Perceval sutureless bioprosthesis versus a conventional stented bioprosthesis in patients with symptomatic severe...

  • Article
  • Open Access
683 Views
10 Pages

Perinatal Socioeconomic Disadvantage and Cardiovascular Comorbidities: National and State-Level Results of a Novel Cardio-Obstetrics Program

  • Sakshi Sehgal,
  • Elinita Pollard,
  • Toscha Charles,
  • Marquetta Thomas,
  • Marlo Vernon,
  • Gyanendra Sharma and
  • Chadburn Ray

Perinatal cardiovascular disease accounts for nearly one-third of pregnancy-related deaths, with nearly 70% of these deaths preventable with appropriate cardio-obstetric care. The objective is to assess whether socioeconomic disadvantage, utilizing a...

  • Article
  • Open Access
894 Views
13 Pages

Background: After recovery from acute sepsis, patients can exhibit left ventricular systolic dysfunction (LVSD) and non-ischaemic myocardial fibrosis. The relationship between myocardial fibrosis and LVSD remains poorly defined. This study sought to...

  • Article
  • Open Access
798 Views
11 Pages

Coronary Artery Calcification in Patients with Radiographic Axial Spondyloarthritis: A Comparative Study with Matched Controls in Southwestern Sweden

  • Erik Hulander,
  • Anna Deminger,
  • Sofia Enegren,
  • Magnus Hallström,
  • Caroline Feldthusen,
  • Erika Fagman,
  • Oskar Angerås,
  • Tatiana Zverkova Sandström,
  • Mats Geijer and
  • Helena Forsblad-d’Elia

Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA....

  • Article
  • Open Access
1,634 Views
14 Pages

Introduction: Previous studies have reported sex differences in stroke. There are few Asian studies. This study was performed to investigate sex differences in stroke risk factors and mechanisms in a multi-ethnic Asian population. Methods: Data on pa...

  • Article
  • Open Access
537 Views
10 Pages

Decreased Aortic Elasticity in Noncompaction Cardiomyopathy Compared to Dilated Cardiomyopathy

  • Martijn Tukker,
  • Sharida Mohamedhoesein,
  • Emrah Kaya,
  • Arend F.L. Schinkel and
  • Kadir Caliskan

Abnormal aortic elasticity serves as a marker for cardiovascular mortality and has a negative impact on the left ventricular (LV) afterload. Noncompaction cardiomyopathy (NCCM) is characterized by hypertrabeculation of the LV endomyocardial wall, wit...

  • Review
  • Open Access
3,458 Views
17 Pages

Advancing Heart Failure Care Through Disease Management Programs: A Comprehensive Framework to Improve Outcomes

  • Maha Inam,
  • Robert M. Sangrigoli,
  • Linda Ruppert,
  • Pooja Saiganesh and
  • Eman A. Hamad

Heart failure (HF) is a major global health challenge, characterized by high morbidity, mortality, and frequent hospital readmissions. Despite the advent of guideline-directed medical therapies (GDMTs), the burden of HF continues to grow, necessitati...

  • Article
  • Open Access
788 Views
13 Pages

Lipomatous Hypertrophy of the Interatrial Septum (LHIS) a Biomarker for Cardiovascular Protection? A Hypothesis Generating Case–Control Study

  • Pietro G. Lacaita,
  • Valentin Bilgeri,
  • Fabian Barbieri,
  • Yannick Scharll,
  • Wolfgang Dichtl,
  • Gerlig Widmann and
  • Gudrun M. Feuchtner

Background: While epicardial adipose tissue (EAT) is a known predictor of adverse cardiovascular outcomes, lipomatous hypertrophy of the interatrial septum (LHIS) is composed of metabolically active fat such as brown adipose tissue, which may exert a...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425