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Journal of Cardiovascular Development and Disease, Volume 12, Issue 9

2025 September - 53 articles

Cover Story: Telomere shortening is increasingly recognised as a key driver of vascular aging and a risk factor for atherosclerotic cardiovascular disease. Astragalus membranaceus, a traditional medicinal plant, and its active compounds, including astragaloside IV, cycloastragenol, and the telomerase activator TA-65, are emerging as promising agents capable of modulating telomerase, preserving telomere length, and exerting antioxidant and anti-inflammatory effects. This review summarises mechanistic evidence supporting their vascular protective properties, highlights knowledge gaps, and outlines future research directions to validate their role in preventing atherosclerosis and promoting healthy vascular aging. View this paper
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Articles (53)

  • Article
  • Open Access
968 Views
17 Pages

With the advancement of fractional flow reserve (FFR) derived from computed tomography (FFRCT), virtual stenting technology has gradually developed. This study investigated the performance of virtual stenting based on FFRCT in predicting post-percuta...

  • Article
  • Open Access
1,173 Views
16 Pages

Extracellular Volume Fraction Analysis on Cardiac Computed Tomography Is Useful for Predicting the Prognosis of Hypertrophic Cardiomyopathy

  • Shuhei Aoki,
  • Hiroyuki Takaoka,
  • Tomonori Kanaeda,
  • Kazunari Asada,
  • Joji Ota,
  • Yoshitada Noguchi,
  • Moe Matsumoto,
  • Yusei Nishikawa,
  • Katsuya Suzuki and
  • Yoshio Kobayashi
  • + 7 authors

Extracellular volume fraction (ECV) analysis on computed tomography (CT) is now available. The purpose of this study was to assess the usefulness of CT-derived ECV analysis for predicting outcomes in patients with hypertrophic cardiomyopathy (HCM). O...

  • Article
  • Open Access
801 Views
17 Pages

ADAMTS5 Orchestrates Cell Lineage Specific Patterning and Extracellular Matrix Organization During Semilunar Valve Development

  • Loren E. Dupuis,
  • Joshua J. Mifflin,
  • Amy L. Marston,
  • Jeremy P. Laxner and
  • Christine B. Kern

Aortic valve (AV) disease affects about 5% of the aging population, with AV replacement as the only treatment option. Histopathology indicates that accumulation of extracellular matrix (ECM) proteoglycans correlates with dysfunctional AVs. Proteoglyc...

  • Article
  • Open Access
1,217 Views
21 Pages

There is a clinical need for improved antenatal diagnosis of congenital heart disease (CHD). Increasing numbers of children are born to parents undergoing fertility treatment. We asked whether time-lapse imaging of in vitro preimplantation developmen...

  • Article
  • Open Access
909 Views
13 Pages

Impaired Left Atrial Strain as an Early Marker of Cardiac Involvement in Type 2 Diabetes Mellitus: A Cross-Sectional Study

  • Laura-Cătălina Benchea,
  • Larisa Anghel,
  • Nicoleta Dubei,
  • Răzvan-Liviu Zanfirescu,
  • Gavril-Silviu Bîrgoan,
  • Radu Andy Sascău and
  • Cristian Stătescu

Background: Diabetic cardiomyopathy is a major contributor to cardiovascular morbidity, often progressing silently before overt heart failure. Left atrial (LA) strain, assessed via speckle-tracking echocardiography, could serve as an early indicator...

  • Article
  • Open Access
1,057 Views
19 Pages

Early and 3-Year Outcomes of Frozen Elephant Trunk Procedure with Evolving E-vita Hybrid Grafts: A Retrospective Single-Centre Cohort Study over 11 Years

  • Isabelle Doll,
  • Christoph Salewski,
  • Luise Vöhringer,
  • Michael Baumgaertner,
  • Attila Nemeth,
  • Christian Schlensak and
  • Medhat Radwan

Background/Objectives: The frozen elephant trunk (FET) technique is a cornerstone procedure for complex thoracic aortic pathologies. This single-center retrospective study evaluates early and midterm outcomes of total arch replacement (TAR) using thr...

  • Review
  • Open Access
1 Citations
2,200 Views
26 Pages

Sjogren’s Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment

  • Jennifer Behbodikhah,
  • Billy Ding,
  • Belin Jacob,
  • Nuzhat Batool,
  • Elise Belilos,
  • Joshua De Leon,
  • Steven E. Carsons and
  • Allison B. Reiss

Autoimmune disorders are known to accelerate atherosclerosis, increasing the rate of cardiovascular disease. As the number one cause of morbidity and mortality in the general population, this risk is only enhanced in inflammatory conditions. Substant...

  • Brief Report
  • Open Access
992 Views
8 Pages

Pulmonary hypertension (PH) with chronic obstructive pulmonary disease (COPD) is associated with poor survival with no approved therapies. We report on the response to inhaled treprostinil (iTRE) of a small retrospective cohort of PH-COPD patients wi...

  • Review
  • Open Access
2 Citations
2,900 Views
33 Pages

Between Air and Artery: A History of Cardiopulmonary Bypass and the Rise of Modern Cardiac Surgery

  • Vasileios Leivaditis,
  • Andreas Maniatopoulos,
  • Francesk Mulita,
  • Paraskevi Katsakiori,
  • Nikolaos G. Baikoussis,
  • Sofoklis Mitsos,
  • Elias Liolis,
  • Vasiliki Garantzioti,
  • Konstantinos Tasios and
  • Manfred Dahm
  • + 6 authors

Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs. This review starts with ancient concepts of cardiop...

  • Article
  • Open Access
864 Views
12 Pages

Outcomes of Use of Inotropes at Waitlisting Through Heart Transplantation: The UNOS Experience

  • Marco Gemelli,
  • Ilias P. Doulamis,
  • Thanakorn Rojanathagoon,
  • Aspasia Tzani,
  • Athanasios Rempakos,
  • Polydoros Kampaktsis,
  • Alvise Guariento,
  • Ernesto Ruiz Dunque,
  • Rabea Asleh and
  • Alexandros Briasoulis
  • + 3 authors

Background: Despite its use in patients awaiting heart transplant (HT), the impact of continuous inotropic support on short-term complications and long-term transplant outcomes remains unclear. This study evaluated inotrope use at the time of HT on p...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425