Insights into Left Bundle Branch Pacing Mechanics and Efficacy

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Electrophysiology and Cardiovascular Physiology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 57

Special Issue Editor


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Guest Editor
Cardiology Unit, Sant’Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy
Interests: pacemakers; ICDs; cardiac conduction system pacing; pulse filed ablation; atrial fibrillation

Special Issue Information

Dear Colleagues,

Left bundle branch area pacing (LBBAP) has emerged as a promising modality within conduction system pacing (CSP), offering a more accessible and technically feasible alternative to His bundle pacing (HBP), while maintaining favorable electrical parameters and long-term pacing stability. However, while LBBAP shows encouraging clinical outcomes, much remains unknown about the mechanical and functional effects it induces on the ventricular myocardium.

The left bundle branch (LBB) area is anatomically complex and extensive, encompassing the main trunk as well as anterior, posterior, and septal fascicles. Depending on the exact pacing site—whether in the proximal trunk, one of the fascicles, or even deep within the left septal subendocardial region—mechanical synchronization, electrical activation, and overall myocardial work efficiency may vary significantly. These physiological nuances are not yet fully understood and warrant in-depth investigation.

This Special Issue welcomes the submission of original research articles, reviews, and case studies that provide insights into ventricular mechanics, electromechanical coupling, myocardial work efficiency, and clinical outcomes associated with various LBBAP pacing strategies. We particularly welcome contributions that explore advanced imaging techniques, computational modeling, and long-term follow-up data to elucidate these dynamics.

Dr. Francesco Vitali
Guest Editor

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Keywords

  • left bundle branch area pacing
  • conduction system pacing
  • ventricular mechanics
  • myocardial work efficiency
  • septal pacing
  • cardiac resynchronization therapy

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Published Papers (1 paper)

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8 pages, 2695 KiB  
Case Report
Double QRS Transition Due to Anodal Capture During Left Bundle Branch Area Pacing: A Case Report
by Angelo Melpignano, Francesco Vitali, Luca Canovi, Jacopo Bonini, Ludovica Rita Vocale and Matteo Bertini
J. Cardiovasc. Dev. Dis. 2025, 12(8), 299; https://doi.org/10.3390/jcdd12080299 - 3 Aug 2025
Abstract
Anodal capture, characterized by a different QRS morphology compared to cathodal capture, is a well-known issue in cardiac resynchronization therapy (CRT). Left bundle branch area pacing (LBBAP), a novel physiological pacing technique, is also used as a bailout strategy following failed conventional CRT [...] Read more.
Anodal capture, characterized by a different QRS morphology compared to cathodal capture, is a well-known issue in cardiac resynchronization therapy (CRT). Left bundle branch area pacing (LBBAP), a novel physiological pacing technique, is also used as a bailout strategy following failed conventional CRT implantation. In LBBAP, QRS transition, defined by a change in paced QRS morphology, serves as a key marker of successful lead placement. This case report is the first to document both high-output anodal capture and LBBAP-induced QRS transition in a single individual receiving LBBAP with an implantable cardioverter–defibrillator (ICD) as a bailout strategy for failed cardiac resynchronization therapy with defibrillator (CRT-D) implantation. Their coexistence underscores unique device optimization challenges in this emerging approach. Full article
(This article belongs to the Special Issue Insights into Left Bundle Branch Pacing Mechanics and Efficacy)
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