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Clinical Burden of Comorbidities on Cardiovascular System and Beyond: 2nd...
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Clinical Burden of Comorbidities on Cardiovascular System and Beyond: 2nd Edition

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiovascular Clinical Research".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 998

Special Issue Editor

Prof. Dr. Zbigniew Siudak

E-Mail Website
Guest Editor
Medical College, Jan Kochanowski University, 25-317 Kielce, Poland
Interests: epidemiology; co-morbidities; acute coronary syndromes; diabetes; inflammation; platelets; PCI; statistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The scope of this JCDD Special Issue is to promote a multidisciplinary approach to cardiovascular disease and its burden. Atherosclerosis is a generalized inflammatory process that almost never impacts solely on the heart and coronary system. Recent decades, but also the COVID-19 pandemic, have underlined the importance of comorbidities on cardiovascular disease and outcomes. We seek novel and bold analyses of known and hypothetical but currently untested markers, imaging methods and co-morbidities on the heart and vessels.

This Special Issue will provide a platform for the presentation of recent advances in knowledge on the development of cardiovascular disease from diverse scientific disciplines including internal medicine and cardiac surgery, as well as basic sciences and dentistry. The broad focus of the Special Issue will enhance our understanding of the range of cardiovascular disease burden.

Prof. Dr. Zbigniew Siudak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • co-morbidity
  • inflammation
  • valves
  • stents
  • epidemiology
  • coronary
  • diabetes
  • gender
  • age
  • markers

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Related Special Issue

Published Papers (1 paper)

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Research

13 pages, 239 KiB  
Article
In-Hospital Mortality and Costs of Added Morbidity in Heart Failure Patients at a University Hospital: A Retrospective Cross-Sectional Study
by Lourdes Raya Ortega, Jesús Martínez Tapias, María José Ferreras Fernández, Manuel Jiménez-Navarro, Almudena Ortega-Gómez, Miguel Romero-Cuevas and Juan José Gómez-Doblas
J. Cardiovasc. Dev. Dis. 2025, 12(5), 185; https://doi.org/10.3390/jcdd12050185 - 15 May 2025
Viewed by 772
Abstract
Background: Heart failure (HF) is a leading cause of hospital admissions and in-hospital mortality among the elderly. This study aims to characterize HF patients admitted to Virgen de la Victoria University Hospital (HUVV), identify factors associated with in-hospital mortality and analyze the impact [...] Read more.
Background: Heart failure (HF) is a leading cause of hospital admissions and in-hospital mortality among the elderly. This study aims to characterize HF patients admitted to Virgen de la Victoria University Hospital (HUVV), identify factors associated with in-hospital mortality and analyze the impact of added morbidity on healthcare costs. Methods: A cross-sectional study was conducted using data from the Minimum Basic Data Set (MBDS) at HUVV. We included all discharges with a primary diagnosis of HF in 2021. Logistic regression analysis was employed to identify factors associated with mortality, and cost analysis was performed to assess the economic impact of added morbidity. Results: A total of 731 hospital discharges for HF were analyzed, with a mortality rate of 14.77%. Mortality was significantly associated with age ≥ 75 years (OR = 4.12; p < 0.001), high or extreme severity (OR = 2.26 and 8.10, respectively; p < 0.001), and more than 10 diagnoses at discharge (OR = 2.95; p < 0.01). Treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) was associated with a reduced risk of death (OR = 0.29; p < 0.001). Hospital-acquired morbidity occurred in 27.22% of patients, resulting in an additional cost of EUR 152,780.61, representing a 3.8% increase over the total hospitalization costs. Conclusions: In-hospital mortality in HF patients at HUVV is strongly associated with advanced age, disease severity, and multiple comorbidities. Treatment with ACEIs or ARBs was associated with a lower likelihood of in-hospital mortality. Preventable added morbidity was associated with increased healthcare costs, highlighting the importance of infection control measures and multidisciplinary management to potentially improve outcomes and reduce costs. Full article
(This article belongs to the Special Issue Clinical Burden of Comorbidities on Cardiovascular System and Beyond: 2nd Edition)
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