Table of Contents
Foods, Volume 9, Issue 4 (April 2020) – 159 articles
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Cover Story (view full-size image) Legumes are rich sources of health-promoting bioactives such as saponins. Epidemiological studies [...] Read more. Legumes are rich sources of health-promoting bioactives such as saponins. Epidemiological studies suggest that saponins could be beneficial to human health by lowering cholesterol and playing a preventive role in cancer development. Therefore, they could represent targets for nutritional therapies and development of functional foods. We found that, following the consumption of a soya-rich diet by human volunteers, sapogenol was the major plasma and fecal metabolite. We established that the human gut is the primary site for saponin metabolism to sapogenol by microbiota; consequently, the systemic metabolites of soyasaponin are absorbed from the gut and are bioavailable in plasma as conjugates of sapogenol. The metabolism and bioavailability of biologically active molecules provide key information necessary for the efficient development of functional foods. View this paper