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Article

Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health

by
Michio Hashimoto
1,*,
Kentaro Matsuzaki
1,
Setsushi Kato
2,
Shahdat Hossain
1,3,
Miho Ohno
2 and
Osamu Shido
1
1
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan
2
Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane 696-0001, Japan
3
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
*
Author to whom correspondence should be addressed.
Foods 2020, 9(4), 530; https://doi.org/10.3390/foods9040530
Submission received: 19 March 2020 / Revised: 18 April 2020 / Accepted: 21 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Oils and Bioactive Lipids: Quality, Stability, and Funcitionality)
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Abstract

Perilla oil (PO), rich in α-linolenic acid (LNA, C18:3, ω-3), is increasingly alleged to have numerous health benefits in humans. However, the current reports detailing the effects of PO on human mental health are not adequate. Therefore, in the current investigation we compared the effects of PO or placebo treatment on the mental condition of healthy adult Japanese volunteers. At baseline and after 12 months of treatment, mental health condition was assessed using the Zung Self-Rating Depression Scale (SDS) and Apathy Scale, and serum biochemical parameters were determined. From baseline to 12 months of intervention, both SDS depression and apathy scores improved significantly in the PO-administered group. Compared to those of control group, serum norepinephrine and serotonin levels after 12 months decreased in the PO-administered group. The enhanced mental state observed in PO-subjects was accompanied by LNA level increases in erythrocyte plasma membranes. Our data demonstrate that PO intake enhances blood LNA levels and may maintain healthy mental conditions in adult subjects.
Keywords: perilla oil; α-linolenic acid; mental health; depression; apathy; ω-polyunsaturated fatty acid perilla oil; α-linolenic acid; mental health; depression; apathy; ω-polyunsaturated fatty acid

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MDPI and ACS Style

Hashimoto, M.; Matsuzaki, K.; Kato, S.; Hossain, S.; Ohno, M.; Shido, O. Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health. Foods 2020, 9, 530. https://doi.org/10.3390/foods9040530

AMA Style

Hashimoto M, Matsuzaki K, Kato S, Hossain S, Ohno M, Shido O. Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health. Foods. 2020; 9(4):530. https://doi.org/10.3390/foods9040530

Chicago/Turabian Style

Hashimoto, Michio, Kentaro Matsuzaki, Setsushi Kato, Shahdat Hossain, Miho Ohno, and Osamu Shido. 2020. "Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health" Foods 9, no. 4: 530. https://doi.org/10.3390/foods9040530

APA Style

Hashimoto, M., Matsuzaki, K., Kato, S., Hossain, S., Ohno, M., & Shido, O. (2020). Twelve-Month Studies on Perilla Oil Intake in Japanese Adults—Possible Supplement for Mental Health. Foods, 9(4), 530. https://doi.org/10.3390/foods9040530

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