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Separations, Volume 7, Issue 4

December 2020 - 26 articles

Cover Story: Nanoliquid chromatography has enabled the enantiomeric separation of two chiral drugs, lacosamide and colchicine, in less than 8 and 9 min with enantiomeric resolutions of 1.6 and 2.3, respectively. A capillary column lab-packed with an amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phase was used. This methodology is characterized by the low volume of mobile phase and sample required (1.8 µL per analysis and 20 nL sample). The proposed method can detect the enantiomeric impurities of both drugs up to a 0.1% with respect to the majority enantiomer and can successfully be applied to ensure quality control of these drugs in pharmaceutical formulations. View this paper.
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Articles (26)

  • Article
  • Open Access
28 Citations
4,951 Views
12 Pages

A novel sample preparation method based on the use of the Arrow solid-phase microextraction device was used to extract and preconcentrate volatile organic compounds (VOCs) from milk samples prior to their determination by gas chromatography–mas...

  • Article
  • Open Access
6 Citations
4,982 Views
15 Pages

Selective TiO2 Phosphopeptide Enrichment of Complex Samples in the Nanogram Range

  • Gábor Tóth,
  • Fanni Bugyi,
  • Simon Sugár,
  • Goran Mitulović,
  • Károly Vékey,
  • Lilla Turiák and
  • László Drahos

Phosphopeptide enrichment is a commonly used sample preparation step for investigating phosphorylation. TiO2-based enrichment has been demonstrated to have excellent performance both for large amounts of complex and for small amounts of simple sample...

  • Article
  • Open Access
12 Citations
4,631 Views
15 Pages

Separation of the Glycosylated Carotenoid Myxoxanthophyll from Synechocystis Salina by HPCCC and Evaluation of Its Antioxidant, Tyrosinase Inhibitory and Immune-Stimulating Properties

  • Michaela Nováková,
  • Tereza Fábryová,
  • Doris Vokurková,
  • Iva Dolečková,
  • Jiří Kopecký,
  • Pavel Hrouzek,
  • Lenka Tůmová and
  • José Cheel

Global demand for natural pigments has increased in the past few years. Myxoxanthophyll, a glycosylated monocyclic carotenoid, is a pigment that occurs naturally in cyanobacteria but no scalable isolation process has been developed to obtain it from...

  • Article
  • Open Access
14 Citations
5,163 Views
13 Pages

Determination of Carminic Acid in Foodstuffs and Pharmaceuticals by Microchip Electrophoresis with Photometric Detection

  • Marián Masár,
  • Jasna Hradski,
  • Eva Vargová,
  • Adriána Miškovčíková,
  • Peter Božek,
  • Juraj Ševčík and
  • Roman Szucs

This paper presents a novel miniaturized analytical method for the determination of carminic acid, a natural red food dye, in complex food and pharmaceutical matrices by microchip electrophoresis (MCE) with photometric detection. MCE has become a ver...

  • Article
  • Open Access
15 Citations
3,603 Views
20 Pages

Synthesis and Characterization of B/NaF and Silicon Phthalocyanine-Modified TiO2 and an Evaluation of Their Photocatalytic Removal of Carbamazepine

  • Chukwuka B. Anucha,
  • IIknur Altin,
  • Debora Fabbri,
  • Ismail Degirmencioglu,
  • Paola Calza,
  • Giuliana Magnacca,
  • Vassilis N. Stathopoulos and
  • Emin Bacaksiz

This study investigated the synthesis of two different types of photocatalysts, namely, boron/sodium fluoride co-doped titanium dioxide (B/NaF-TiO2), and its analogue, a dye-sensitized form of silicon-based axial methoxy substituted phthalocyanine (B...

  • Article
  • Open Access
13 Citations
5,108 Views
17 Pages

Base oils are produced by refining crude oil or through chemical synthesis. They are a key component of engine oils. With an immense range of carbon numbers and boiling points, analyzing such complex mixtures is very difficult. The need to monitor in...

  • Article
  • Open Access
10 Citations
4,277 Views
32 Pages

Poly(ethylene-co-vinylalcohol) (E-VOH) and carbon nanotube-filled poly (vinyl alcohol-co-ethylene) (E-VOH/CNT) were used as membranes to separate benzene/cyclohexane mixtures by pervaporation technique. To reach this goal, E-VOH and E-VOH/CNT membran...

  • Review
  • Open Access
23 Citations
4,767 Views
28 Pages

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

  • Sagrario Torres-Cartas,
  • Mónica Catalá-Icardo,
  • Susana Meseguer-Lloret,
  • Ernesto F. Simó-Alfonso and
  • José Manuel Herrero-Martínez

This review describes the recent advances from the past five years concerning the development and applications of molecularly imprinted membranes (MIMs) in the field of sample treatment and separation processes. After a short introduction, where the...

  • Article
  • Open Access
29 Citations
4,559 Views
9 Pages

In this study, a method for the determination of trace elements in snacks using inductively coupled plasma–atomic emission spectrometry (ICP-AES) is presented. The examined elements were Pb, Ni, Cr, Cu, Mg, Zn, Fe, Al, Ba, Ca, Co, Mn and Cd. Un...

  • Article
  • Open Access
20 Citations
5,792 Views
12 Pages

Bioethanol Production from Date Seed Cellulosic Fraction Using Saccharomyces cerevisiae

  • Fatma Bouaziz,
  • Amal Ben Abdeddayem,
  • Mohamed Koubaa,
  • Francisco J. Barba,
  • Khawla Ben Jeddou,
  • Imen Kacem,
  • Raoudha Ellouz Ghorbel and
  • Semia Ellouz Chaabouni

This study investigates the feasibility of producing ethanol from date palm seeds. The chemical compositions of three varieties of date seeds were first studied, showing mainly the presence of cellulose and hemicellulose. Ethanol was produced after a...

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Separations - ISSN 2297-8739