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Children, Volume 12, Issue 11

November 2025 - 153 articles

Cover Story: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are reshaping pediatric obesity and type 2 diabetes management, with approved products offering significant BMI and weight reductions. However, major knowledge gaps remain. Long-term safety and durability of effect in youth are unknown, particularly regarding bone health, lean mass preservation, and neurohormonal development. Optimal dosing, duration, and criteria for treatment discontinuation risk for weight rebound require further study. This review integrates clinical and mechanistic evidence while underscoring the urgent need for longitudinal, pediatric-specific research to inform safe and effective obesity pharmacotherapy in growing children. View this paper
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Articles (153)

  • Review
  • Open Access
288 Views
14 Pages

Pediatric Thoracic MRI: Safer, Sharper and Smarter Diagnostics

  • Patricia Tischendorf,
  • Laura Beck and
  • Tobias Krähling

20 November 2025

Background: Pediatric thoracic magnetic resonance imaging (MRI) has evolved into a valuable diagnostic modality that offers high-resolution morphological and functional assessment. While conventional radiography and computed tomography (CT) remain st...

  • Article
  • Open Access
263 Views
14 Pages

Medical Child Abuse: A Retrospective Analysis from a Tertiary Pediatric Hospital’s Childhood and Adolescent Abuse Group

  • Martina Focardi,
  • Marta Guerini,
  • Beatrice Defraia,
  • Laura Nanni,
  • Rossella Grifoni,
  • Giovanni Castellini,
  • Barbara Gualco,
  • Ilenia Bianchi,
  • Vilma Pinchi and
  • Stefania Losi

20 November 2025

Background: Medical child abuse (MCA), previously known as Münchausen syndrome by proxy, involves the fabrication or induction of illness by caregivers—most commonly the mother—leading to unnecessary medical interventions and potenti...

  • Article
  • Open Access
295 Views
12 Pages

19 November 2025

Background: Metabolic bone disease (MBD) of prematurity predisposes extremely preterm and extremely low birth weight (ELBW) infants to atraumatic fractures. Evidence on fracture reduction after structured Bone Health Programs (BHPs) remains limited....

  • Review
  • Open Access
336 Views
14 Pages

MicroRNA Profiling as a Novel Tool in the Diagnostics of Late-Onset Neonatal Sepsis: A Scoping Review

  • Eleni Papachatzi,
  • Eleni Gkouti,
  • Adamantia Kouvela,
  • Sofia Benou,
  • Gabriel Dimitriou,
  • Sotiris Fouzas,
  • Vassiliki Stamatopoulou and
  • Despoina Gkentzi

19 November 2025

Background/Objectives: The incidence of late-onset sepsis (LOS) has increased with improved survival rates in premature infants. Blood culture, the diagnostic “gold standard”, requires at least 36–72 h for results, leading to empiri...

  • Article
  • Open Access
278 Views
14 Pages

Incidence, Risk Factors and Outcomes of Junctional Ectopic Tachycardia After Tetralogy of Fallot Repair in Pediatric Patients

  • Fatih Durak,
  • Gokcen Ozcifci,
  • Emine Pinar Kulluoglu,
  • Ayse Berna Anil,
  • Onur Isik,
  • Muhammet Akyuz and
  • Baris Guven

19 November 2025

Background: Postoperative junctional ectopic tachycardia (JET) is a potentially life-threatening arrhythmia that may occur after congenital heart surgery, especially following tetralogy of Fallot (TOF) repair. It can cause hemodynamic instability due...

  • Article
  • Open Access
273 Views
9 Pages

19 November 2025

Introduction: Idiopathic gynecomastia is a common diagnosis among adolescents. Closed-suction drain placement after breast resection is traditionally performed to prevent complications such as seroma or hematoma, although its effectiveness remains co...

  • Article
  • Open Access
491 Views
13 Pages

Prenatal Cocaine Exposure, Perinatal Risks, and Mediators to Preadolescent Attention Deficit Hyperactivity Disorder (ADHD)

  • Thitinart Sithisarn,
  • Carla M. Bann,
  • Barry Lester,
  • Seetha Shankaran,
  • Toni Whitaker,
  • Rosemary D. Higgins and
  • Henrietta Bada

19 November 2025

Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral problem in children. Multiple risk factors, including prenatal substance exposure, have been associated with this disorder. Objectives: We determined (1) the rate of ADHD i...

  • Article
  • Open Access
774 Views
14 Pages

Between Support and Risk: The Dual Role of Peer Relationships in Adolescents’ Mental Health

  • Maria João Carapeto,
  • Inês Agostinho,
  • Luísa Grácio and
  • Daniela Santos

18 November 2025

Background/Objectives: Adolescence is a developmental stage marked by profound transformations and heightened vulnerability to mental health difficulties, with peer relationships playing a central role, as they provide both protective and risk factor...

  • Article
  • Open Access
406 Views
22 Pages

18 November 2025

Background/objectives: Speech sound disorder (SSD) and developmental language disorder (DLD) are common childhood disorders of communication that can also co-occur. This study investigated the reported content, format and delivery of UK speech and la...

  • Article
  • Open Access
366 Views
17 Pages

Antibiotic Resistance Trends in Recurrent Paediatric Urinary Tract Infections: A Five-Year Single-Centre Experience

  • Olivia-Oana Stanciu,
  • Mircea Andriescu,
  • Andreea Moga,
  • Ruxandra Caragata,
  • Laura Balanescu and
  • Radu Balanescu

18 November 2025

Background: Recurrent urinary tract infections (rUTIs) in children are increasingly complicated by antimicrobial resistance, leading to limited treatment options and challenging prophylactic management. Continuous local monitoring of resistance trend...

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Children - ISSN 2227-9067