Table of Contents
Biomolecules, Volume 9, Issue 1 (January 2019)
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Cover Story (view full-size image) The alignment of chromosomes to the spindle equator during mitosis, which is a prerequisite for [...] Read more. The alignment of chromosomes to the spindle equator during mitosis, which is a prerequisite for proper chromosome segregation, is sometimes delayed, even in physiological conditions. When chromosome alignment is delayed, kinetochore–microtubule attachments of late-aligning chromosomes near spindle poles are unstable and can break. At the expense of elongated prometaphase, metaphase duration becomes shortened, which is insufficient for late-aligned chromosomes to correct erroneous kinetochore–microtubule attachments and form bi-orientation. The persistence of erroneous kinetochore–microtubule attachments at anaphase onset can result in chromosome missegregation such as the appearance of lagging chromosomes. A fraction of lagging chromosomes give rise to aneuploidy or micronuclei formation, causing genomic instability. View Paper here.