Next Article in Journal
Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule
Next Article in Special Issue
High-Throughput Screening of Lipidomic Adaptations in Cultured Cells
Previous Article in Journal
Histone Acetylation Promotes Neutrophil Extracellular Trap Formation
Previous Article in Special Issue
UPLC–MS Triglyceride Profiling in Sunflower and Rapeseed Seeds
Open AccessArticle

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland
Steno Diabetes Center Copenhagen, 2820 Gentofte, Denmark
Children’s Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland
Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland
Fimlab Laboratories, Pirkanmaa Hospital District, 33014 Tampere, Finland
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, 20520 Turku, Finland
Clinical Microbiology, Turku University Hospital, 20014 Turku, Finland
Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, 20014 Turku, Finland
Department of Pediatrics, Turku University Hospital, 20521 Turku, Finland
Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, 90014 Oulu, Finland
Department of Children and Adolescents, Oulu University Hospital, 90220 Oulu, Finland
Department of Women’s and Children’s Health, Karolinska Institutet, 17177 Stockholm, Sweden
School of Science and Technology, Örebro University, 70281 Örebro, Sweden
Tampere Center for Child Health Research, Tampere University Hospital, 33520 Tampere, Finland
Folkhälsan Research Center, 00290 Helsinki, Finland
School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden
Authors to whom correspondence should be addressed.
Biomolecules 2019, 9(1), 33;
Received: 7 December 2018 / Revised: 8 January 2019 / Accepted: 15 January 2019 / Published: 21 January 2019
(This article belongs to the Special Issue Lipidomics)
Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR. View Full-Text
Keywords: type 1 diabetes; cord blood; lipidomics; metabolomics; autoimmunity type 1 diabetes; cord blood; lipidomics; metabolomics; autoimmunity
Show Figures

Figure 1

MDPI and ACS Style

Lamichhane, S.; Ahonen, L.; Sparholt Dyrlund, T.; Dickens, A.M.; Siljander, H.; Hyöty, H.; Ilonen, J.; Toppari, J.; Veijola, R.; Hyötyläinen, T.; Knip, M.; Oresic, M. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules 2019, 9, 33.

AMA Style

Lamichhane S, Ahonen L, Sparholt Dyrlund T, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules. 2019; 9(1):33.

Chicago/Turabian Style

Lamichhane, Santosh; Ahonen, Linda; Sparholt Dyrlund, Thomas; Dickens, Alex M.; Siljander, Heli; Hyöty, Heikki; Ilonen, Jorma; Toppari, Jorma; Veijola, Riitta; Hyötyläinen, Tuulia; Knip, Mikael; Oresic, Matej. 2019. "Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes" Biomolecules 9, no. 1: 33.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop