Next Article in Journal
Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells
Previous Article in Journal
Annatto (Bixa orellana) δ-TCT Supplementation Protection against Embryonic Malformations through Alterations in PI3K/Akt-Cyclin D1 Pathway
Previous Article in Special Issue
Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function
Article Menu

Export Article

Open AccessReview
Biomolecules 2019, 9(1), 20;

Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis

Department of Entomology and Plant Pathology Auburn University, Auburn, AL 36849, USA
Author to whom correspondence should be addressed.
Received: 19 November 2018 / Revised: 22 December 2018 / Accepted: 2 January 2019 / Published: 10 January 2019
Full-Text   |   PDF [535 KB, uploaded 11 January 2019]   |  


Cyclophilins (CYPs) belong to a peptidyl-prolyl cis-trans isomerase family, and were first characterized in mammals as a target of an immunosuppressive drug, cyclosporin A, preventing proinflammatory cytokine production. In Arabidopsis, 29 CYPs and CYP-like proteins are found across all subcellular compartments, involved in various physiological processes including transcriptional regulation, organogenesis, photosynthetic and hormone signaling pathways, stress adaptation and defense responses. These important but diverse activities of CYPs must be reflected by their versatility as cellular and molecular modulators. However, our current knowledge regarding their mode of actions is still far from complete. This review will briefly revisit recent progresses on the roles and mechanisms of CYPs in Arabidopsis studies, and information gaps within, which help understanding the phenotypic and environmental plasticity of plants. View Full-Text
Keywords: Cyclophilin; PPlases; Arabidopsis; organogenesis; defense responses Cyclophilin; PPlases; Arabidopsis; organogenesis; defense responses

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Barbosa dos Santos, I.; Park, S.-W. Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis. Biomolecules 2019, 9, 20.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top