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Biomolecules 2019, 9(1), 28; https://doi.org/10.3390/biom9010028

Aurora A Protein Kinase: To the Centrosome and Beyond

University of Rennes, CNRS UMR 6290, IGDR-Institute of Genetics and Development of Rennes, F-35000 Rennes, France
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Received: 7 December 2018 / Revised: 9 January 2019 / Accepted: 9 January 2019 / Published: 15 January 2019
(This article belongs to the Special Issue Cytoskeleton and Regulation of Mitosis)
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Abstract

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division. View Full-Text
Keywords: Aurora A protein kinase; centrosome; mitotic spindle; polarity; centromere; kinetochore; cohesion; transcription Aurora A protein kinase; centrosome; mitotic spindle; polarity; centromere; kinetochore; cohesion; transcription
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Magnaghi-Jaulin, L.; Eot-Houllier, G.; Gallaud, E.; Giet, R. Aurora A Protein Kinase: To the Centrosome and Beyond. Biomolecules 2019, 9, 28.

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