Aurora A Protein Kinase: To the Centrosome and Beyond
AbstractAccurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division. View Full-Text
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Magnaghi-Jaulin, L.; Eot-Houllier, G.; Gallaud, E.; Giet, R. Aurora A Protein Kinase: To the Centrosome and Beyond. Biomolecules 2019, 9, 28.
Magnaghi-Jaulin L, Eot-Houllier G, Gallaud E, Giet R. Aurora A Protein Kinase: To the Centrosome and Beyond. Biomolecules. 2019; 9(1):28.Chicago/Turabian Style
Magnaghi-Jaulin, Laura; Eot-Houllier, Grégory; Gallaud, Emmanuel; Giet, Régis. 2019. "Aurora A Protein Kinase: To the Centrosome and Beyond." Biomolecules 9, no. 1: 28.
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