Special Issue "Intrinsically Disordered Proteins and Chronic Diseases"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (1 March 2019)
Dr. Vladimir N. Uversky
Molecular Medicine, University of South Florida, Tampa, USA
Website | E-Mail
Interests: intrinsically disordered proteins; protein folding; protein misfolding; partially folded proteins; protein aggregation; protein structure; protein function; protein stability; protein biophysics; protein bioinformatics; conformational diseases; protein–ligand interactions; protein–protein interactions; liquid-liquid phase transitions
It is now increasingly evident that a large fraction of the human proteome comprises proteins, or regions within proteins that lack a 3D structure under physiological conditions, and are referred to as intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs), respectively. Despite their lack of a stable structure, IDPs/IDPRs are involved in regulation, signaling, and control, where binding to multiple partners and high-specificity/low-affinity interactions plays a crucial role. Furthermore, intrinsic disorder is a unique structural feature that enables IDPs/IDPRs to participate in, both, one-to-many and many-to-one signaling. Since they serve as general regulators of various cellular processes, IDPs/IDPRs themselves are tightly controlled. However, when overexpressed, miss-expressed, or dysregulated, IDPs/IDPRs are prone to engage in promiscuous, often unwanted interactions and, thus, may lead to the development of various pathological states.
This Special Issue of Biomolecules is dedicated to exploring the role of IDPs in various chronic diseases. The main goal is to compile articles that describe recent progress in elucidating the mechanisms by which IDPs cause variious human diseases, such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, diabetes, genetic diseases, to name just a few.
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Intrinsically Disordered Protein
- Neurodegenerative diseases
- Cardiovascular diseases
- Genetic diseases
- Protein structure
- Protein function