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Biomolecules 2019, 9(1), 35; https://doi.org/10.3390/biom9010035

The Many Faces of FKBP51

Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany
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Received: 7 December 2018 / Revised: 14 January 2019 / Accepted: 14 January 2019 / Published: 21 January 2019
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Abstract

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51’s physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs. View Full-Text
Keywords: FKBP51; Hsp90; NF-κB; GR; glucocorticoids; FK506; SAFit FKBP51; Hsp90; NF-κB; GR; glucocorticoids; FK506; SAFit
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hähle, A.; Merz, S.; Meyners, C.; Hausch, F. The Many Faces of FKBP51. Biomolecules 2019, 9, 35.

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