Special Issue "Phosphoinositide 3-kinase, a Field in Transition"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 30 June 2019
The PI3K-TOR signaling axis is a core cellular regulatory component that controls cell proliferation, motility and metabolism. Gain of function in PI3K signaling is an almost universal hallmark of cancer. Several protein members of that signaling pathway, notably class I PI3Ks, have therefore been in the crosshairs of drug developers. However, after more than 20 years of effort, no breakthrough drug has emerged.
With the expansion of basic knowledge of PI3K signaling came the insight that many of the difficulties encountered with PI3K inhibitors derive from the fact that the PI3K-TOR axis is central to the functioning of normal cells and that interference with activity of wildtype proteins in this system is bound to cause side effects. However, it has also become clear that we know far too little about specific aspects of PI3K signaling, especially about isoform-specific activities and their effects in different genetic settings and different states of cellular differentiation.
The PI3K field is in a state of transition. The experiences with small molecule inhibitors define new challenges and opportunities. In this Biomolecules Special Issue “Phosphoinositide 3-kinase, a Field in Transition”, authors will address urgent fundamental questions with the ultimate goal of driving new advances in medical applications.
Prof. Dr. Peter K. Vogt
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- PI3K-AKT-TOR pathway
- PI3K catalytic and regulatory subunits
- isoform-specific functions
- protein-protein interactions
- cancer-specific somatic mutations
- feedback inhibition
- PI3K and immunity
- small molecule inhibitors
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative Title: Function, Regulation and Biological Roles of PI3Kgamma Variants
Author: Bernd Nürnberg
Abstract: Phosphoinositide 3-kinase (PI3K) gamma is the only class IB PI3K member playing important roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kg occur as two different heterodimeric variants: PI3Kg(p87) and PI3Kg(p101), which share the same p110g catalytic subunit but differ in their associated non-catalytic subunit. Here we concentrate on specific PI3Kg features including its regulation and biological functions. In particular, the roles of its non-catalytic subunits to serve as the main regulators determining specificity of class IB PI3Kg enzymes are highlighted.