Metabolites, Volume 9, Issue 12 (December 2019) – 27 articles
Cover Story (view full-size image): The orphan endothelial cell adhesion G protein-coupled receptor (aGPCR) ADGRL4/ELTD1 regulates physiological and tumour angiogenesis. To better characterise ADGRL4/ELTD1’s role in endothelial cell biology, we silenced ADGRL4/ELTD1 using two independent siRNAs in human umbilical vein endothelial cells (HUVECS) followed by transcriptional profiling, target gene validation and metabolomics using liquid chromatography-mass spectrometry. ADGRL4/ELTD1 expression impacts core components of endothelial metabolism (ACLY, SLC25A1), affecting metabolite levels within pyrimidine, amino acid and sugar metabolic pathways, and regulates genes involved in endothelial differentiation/homeostasis (KIT) and Notch signalling (JAG1, DLL4, HES2). This work establishes a new role for ADGRL4/ELTD1 as a regulator of endothelial metabolism. View this paper
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