Special Issue "Cancer Metabolomics 2019"

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Dr. Bénédicte Elena-Herrmann

Institute for Advanced Biosciences, INSERM/CNRS/Université Grenoble Alpes Grenoble, France
Website | E-Mail
Interests: cancer metabolomics; molecular epidemiology; metabolism and epigenetics; advanced NMR methods; chemometrics

Special Issue Information

Dear Colleagues,

We welcome the submission of original research articles or review papers as contributions to this Special Issue of Metabolites dedicated to cancer metabolomics. The aim for this Issue is to highlight innovative metabolomic approaches, as well as novel achievements of metabolomic investigations in oncology that either provide mechanistic insights into model systems or pertain to translational and clinical studies. Many aspects of metabolomics research, notably in the field of cancerology, contribute to defining disease trajectories that sustain the promotion of P4 medicine—predictive, preventive, personalized, and participatory—to transform healthcare. We therefore encourage contributions that include cross-disciplinary research, involve large-scale data collection and analysis, or involve multi-omics studies for integrative medicine. Noting that over 50% of all cancers develop in a background of pre-existing infectious, immuno-inflammatory or metabolic chronic disease, original work that aims to understand the underlying metabolic mechanisms linking chronic diseases with cancer will be a highly relevant contribution to this Special Issue. Investigations of metabolic markers of risk, early markers of disease, and prognostic markers of the evolution of responses to cancer treatment are equally welcome.

We hope with this Special Issue to provide our readers with a timely overview of metabolomics contemporary research and perspectives in the broad area of cancerology.

Dr. Bénédicte Elena-Herrmann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diagnosis or predictive metabolic markers
  • Tumor metabolism
  • Chronic diseases and cancer
  • Molecular epidemiology of cancer
  • In vivo spectroscopy
  • Model systems

Published Papers (2 papers)

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Research

Open AccessArticle
Defining Metabolic Rewiring in Lung Squamous Cell Carcinoma
Metabolites 2019, 9(3), 47; https://doi.org/10.3390/metabo9030047
Received: 8 February 2019 / Revised: 26 February 2019 / Accepted: 2 March 2019 / Published: 7 March 2019
PDF Full-text (9836 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Metabolomics based on untargeted flow infusion electrospray ionization high-resolution mass spectrometry (FIE-HRMS) can provide a snap-shot of metabolism in living cells. Lung Squamous Cell Carcinoma (SCC) is one of the predominant subtypes of Non-Small Cell Lung Cancers (NSCLCs), which usually shows a poor [...] Read more.
Metabolomics based on untargeted flow infusion electrospray ionization high-resolution mass spectrometry (FIE-HRMS) can provide a snap-shot of metabolism in living cells. Lung Squamous Cell Carcinoma (SCC) is one of the predominant subtypes of Non-Small Cell Lung Cancers (NSCLCs), which usually shows a poor prognosis. We analysed lung SCC samples and matched histologically normal lung tissues from eight patients. Metabolites were profiled by FIE-HRMS and assessed using t-test and principal component analysis (PCA). Differentially accumulating metabolites were mapped to pathways using the mummichog algorithm in R, and biologically meaningful patterns were indicated by Metabolite Set Enrichment Analysis (MSEA). We identified metabolic rewiring networks, including the suppression of the oxidative pentose pathway and found that the normal tricarboxylic acid (TCA) cycle were decoupled from increases in glycolysis and glutamine reductive carboxylation. Well-established associated effects on nucleotide, amino acid and thiol metabolism were also seen. Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of γ-aminobutyric acid (GABA). Our results show the value of FIE-HRMS as a high throughput screening method that could be exploited in clinical contexts. Full article
(This article belongs to the Special Issue Cancer Metabolomics 2019)
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Open AccessArticle
Crosstalk between Metabolic Alterations and Altered Redox Balance in PTC-Derived Cell Lines
Metabolites 2019, 9(2), 23; https://doi.org/10.3390/metabo9020023
Received: 20 December 2018 / Revised: 23 January 2019 / Accepted: 29 January 2019 / Published: 1 February 2019
PDF Full-text (2971 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Background: Thyroid cancer is the most common endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most common (85–90%) among all the different types of thyroid carcinomas. Cancer cells show metabolic alterations and, due to their rapid proliferation, an accumulation of reactive [...] Read more.
Background: Thyroid cancer is the most common endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most common (85–90%) among all the different types of thyroid carcinomas. Cancer cells show metabolic alterations and, due to their rapid proliferation, an accumulation of reactive oxygen species, playing a fundamental role in cancer development and progression. Currently, the crosstalk among thyrocytes metabolism, redox balance and oncogenic mutations remain poorly characterized. The aim of this study was to investigate the interplay among metabolic alterations, redox homeostasis and oncogenic mutations in PTC-derived cells. Methods: Metabolic and redox profile, glutamate-cysteine ligase, glutaminase-1 and metabolic transporters were evaluated in PTC-derived cell lines with distinguished genetic background (TPC-1, K1 and B-CPAP), as well as in an immortalized thyroid cell line (Nthy-ori3-1) selected as control. Results: PTC-derived cells, particularly B-CPAP cells, harboring BRAF, TP53 and human telomerase reverse transcriptase (hTERT) mutation, displayed an increase of metabolites and transporters involved in energetic pathways. Furthermore, all PTC-derived cells showed altered redox homeostasis, as reported by the decreased antioxidant ratios, as well as the increased levels of intracellular oxidant species. Conclusion: Our findings confirmed the pivotal role of the metabolism and redox state regulation in the PTC biology. Particularly, the most perturbed metabolic phenotypes were found in B-CPAP cells, which are characterized by the most aggressive genetic background. Full article
(This article belongs to the Special Issue Cancer Metabolomics 2019)
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Graphical abstract

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