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Open AccessArticle

Metabolomic Profiling Reveals the Difference on Reproductive Performance between High and Low Lactational Weight Loss Sows

1
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu 611130, Sichuan, China
2
Department of Animal Science, Faculty of Science and Technology, Aarhus University, DK-8830 Tjele, Denmark
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Metabolites 2019, 9(12), 295; https://doi.org/10.3390/metabo9120295
Received: 25 October 2019 / Revised: 26 November 2019 / Accepted: 28 November 2019 / Published: 4 December 2019
Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) and low lactational weight loss (LWL) sows. The plasma biochemical parameters, hormones, antioxidant parameters, and milk compositions were assessed. Furthermore, plasma metabolites were analyzed using ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. Results showed that HWL sows had a lower feed intake and higher lactational weight loss and prolonged WEI, but had similar litter performance and milk composition compared to LWL sows. These changes were associated with lower plasma insulin-like growth factor 1 and higher fibroblast growth factor 21 levels in the HWL sows. Moreover, HWL led to a severe oxidative stress and metabolic damage, as accompanied by excessive protein breakdown and lipids mobilization at weaning. Metabolomic analysis revealed differences in 46 compounds between HWL and LWL sows, and the identified compounds were enriched in metabolic pathways related to amino acids metabolism, fatty acids oxidation metabolism, bile acids biosynthesis, and nucleoside metabolism. These results provide the evidence for physiological mechanism in sows with excessive lactational weight loss that delayed the WEI. Metabolomic data provides essential information and gives rise to potential targets for the development of nutritional intervention strategies. View Full-Text
Keywords: lactational weight loss; metabolites; oxidative stress; reproductive performance; sow lactational weight loss; metabolites; oxidative stress; reproductive performance; sow
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Hu, L.; Che, L.; Wu, C.; Curtasu, M.V.; Wu, F.; Fang, Z.; Lin, Y.; Xu, S.; Feng, B.; Li, J.; Zhuo, Y.; Theil, P.K.; Wu, D. Metabolomic Profiling Reveals the Difference on Reproductive Performance between High and Low Lactational Weight Loss Sows. Metabolites 2019, 9, 295.

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