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Metabolites, Volume 14, Issue 10

2024 October - 54 articles

Cover Story: The current understanding of how modified atmospheric packaging (MAP) affects the metabolite profiles of cooked beef is limited. This study aimed to assess the effects of different packaging methods on the color and metabolite composition of both normal-pH and atypical dark-cutting beef. A total of 129 metabolite features were identified in this study. Serine and tryptophan were over-abundant in cooked atypical dark-cutting beef compared to raw atypical samples. This study suggests that packaging conditions change metabolite profiles, which can influence cooked metabolites. View this paper

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Article

3 Citations

2,377 Views

18 Pages

Non-Nucleoside Lycorine-Based Analogs as Potential DENV/ZIKV NS5 Dual Inhibitors: Structure-Based Virtual Screening and Chemoinformatic Analysis

Adrián Camilo Rodríguez-Ararat,
Yasser Hayek-Orduz,
Andrés-Felipe Vásquez,
Felipe Sierra-Hurtado,
María-Francisca Villegas-Torres,
Paola A. Caicedo-Burbano,
Luke E. K. Achenie and
Andrés Fernando González Barrios

Metabolites2024, 14(10), 519;https://doi.org/10.3390/metabo14100519

26 September 2024

Dengue (DENV) and Zika (ZIKV) virus continue to pose significant challenges globally due to their widespread prevalence and severe health implications. Given the absence of effective vaccines and specific therapeutics, targeting the highly conserved...

(This article belongs to the Section Pharmacology and Drug Metabolism)

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Article

4 Citations

2,140 Views

12 Pages

Ultra-High-Performance Liquid Chromatography–High-Definition Mass Spectrometry-Based Metabolomics to Reveal the Potential Anti-Arthritic Effects of Illicium verum in Cultured Fibroblast-like Synoviocytes Derived from Rheumatoid Arthritis

Mingzhen Qin,
Lu Chen,
Xiaoli Hou,
Wuwei Wu,
Yu Liu,
Yu Pan,
Mengli Zhang,
Zhien Tan and
Danna Huang

Metabolites2024, 14(10), 517;https://doi.org/10.3390/metabo14100517

25 September 2024

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The fruits of Illicium verum, which is a medicinal and edible resource, have been shown to have anti-inflammatory properties. Methods: In this study, we investigated...

(This article belongs to the Section Plant Metabolism)

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Article

1 Citations

1,792 Views

9 Pages

The Causal Effect of Urate Level on Female Infertility: A Mendelian Randomization Study

Jiawei Sun,
Ting Shen,
Yining Guan,
Yixin Jiang and
Xiaoling Xu

Metabolites2024, 14(10), 516;https://doi.org/10.3390/metabo14100516

25 September 2024

Background/Objective: This study aimed to investigate the causal relationship between urate level and female infertility using Mendelian randomization (MR) analysis. Methods: To identify instrumental variables, we selected independent genetic loci as...

(This article belongs to the Section Endocrinology and Clinical Metabolic Research)

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Article

3 Citations

2,487 Views

18 Pages

Global and Targeted Metabolomics for Revealing Metabolomic Alteration in Niemann-Pick Disease Type C Model Cells

Masahiro Watanabe,
Masamitsu Maekawa,
Keitaro Miyoshi,
Toshihiro Sato,
Yu Sato,
Masaki Kumondai,
Masayoshi Fukasawa and
Nariyasu Mano

Metabolites2024, 14(10), 515;https://doi.org/10.3390/metabo14100515

24 September 2024

Background: Niemann-Pick disease type C (NPC) is an inherited disorder characterized by a functional deficiency of cholesterol transport proteins. However, the molecular mechanisms and pathophysiology of the disease remain unknown. Methods: In this s...

(This article belongs to the Section Cell Metabolism)

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