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Antibiotics, Volume 10, Issue 7

July 2021 - 135 articles

Cover Story: Antibiotics have served modern medicine well, but the inexorable trend to resistance poses future challenges. Epidemiological surveillance programs, stewardship, and development of new drugs have collectively met urgent needs to address antibiotic resistance. The report by Villanueva et al. using a CA-MRSA strain, MW2, considered a less studied question: does a bacterium possess mechanisms that actually help it to survive low level exposure with antibiotics (in this case ceftaroline)? Most antibiotics are naturally occurring or derivatives, and so bacteria could possibly have evolved protection against sub-therapeutic concentrations. Identifying if this is the case, and by what mechanism, might help antibiotics work better or lead to promising targets for future adjuvant therapy. Indeed, disruption of two environmental-sensing systems led to dramatically enhanced sensitivity to ceftaroline. View this paper.
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Articles (135)

  • Article
  • Open Access
3 Citations
4,356 Views
10 Pages

Non-fermenting Gram-negative rods are one of the most commonly isolated bacteria from human infections. These microorganisms are typically opportunistic pathogens that pose a serious threat to public health due to possibility of transmission in the h...

  • Article
  • Open Access
2 Citations
2,811 Views
14 Pages

Blood Cultures and Appropriate Antimicrobial Administration after Achieving Sustained Return of Spontaneous Circulation in Adults with Nontraumatic Out-of-Hospital Cardiac Arrest

  • Chih-Hao Lin,
  • Po-Lin Chen,
  • Yi-Tzu Huang,
  • Ching-Yu Ho,
  • Chih-Chia Hsieh,
  • William Yu Chung Wang,
  • Ching-Chi Lee and
  • Wen-Chien Ko

We aimed to determine the incidence of bacteremia and prognostic effects of prompt administration of appropriate antimicrobial therapy (AAT) on nontraumatic out-of-hospital cardiac arrest (OHCA) patients achieving a sustained return of spontaneous ci...

  • Article
  • Open Access
10 Citations
5,336 Views
16 Pages

Pseudomonas aeruginosa PAO 1 In Vitro Time–Kill Kinetics Using Single Phages and Phage Formulations—Modulating Death, Adaptation, and Resistance

  • Ana Mafalda Pinto,
  • Alberta Faustino,
  • Lorenzo M. Pastrana,
  • Manuel Bañobre-López and
  • Sanna Sillankorva

Pseudomonas aeruginosa is responsible for nosocomial and chronic infections in healthcare settings. The major challenge in treating P. aeruginosa-related diseases is its remarkable capacity for antibiotic resistance development. Bacteriophage (phage)...

  • Article
  • Open Access
14 Citations
4,395 Views
17 Pages

Efficiency of Antimicrobial Photodynamic Therapy with Photodithazine® on MSSA and MRSA Strains

  • Beatriz Müller Nunes Souza,
  • Juliana Guerra Pinto,
  • André Henrique Correia Pereira,
  • Alejandro Guillermo Miñán and
  • Juliana Ferreira-Strixino

Staphylococccus aureus is a ubiquitous and opportunistic bacteria associated with high mortality rates. Antimicrobial photodynamic therapy (aPDT) is based on the application of a light source and a photosensitizer that can interact with molecular oxy...

  • Article
  • Open Access
42 Citations
4,374 Views
14 Pages

Antibacterial Peptides Produced by Alcalase from Cowpea Seed Proteins

  • Ali Osman,
  • Gamal Enan,
  • Abdul-Raouf Al-Mohammadi,
  • Seham Abdel-Shafi,
  • Samar Abdel-Hameid,
  • Mahmoud Z. Sitohy and
  • Nashwa El-Gazzar

Cowpea seed protein hydrolysates (CPH) were output from cowpea seeds applying alcalase® from Bacillus licheniformis. CPH with an elevated level of hydrolysis was fractionated by size exclusion chromatography (SEC). Both CPH and SEC-portions showed to...

  • Article
  • Open Access
52 Citations
4,570 Views
15 Pages

Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon

  • Mohammed F. Aldawsari,
  • El-Sayed Khafagy,
  • Ahmed Al Saqr,
  • Ahmed Alalaiwe,
  • Hisham A. Abbas,
  • Moataz A. Shaldam,
  • Wael A. H. Hegazy and
  • Reham M. Goda

The bacterial resistance development due to the incessant administration of antibiotics has led to difficulty in their treatment. Natural adjuvant compounds can be co-administered to hinder the pathogenesis of resistant bacteria. Sotolon is the preva...

  • Article
  • Open Access
8 Citations
4,362 Views
8 Pages

Antibiotic Prescriptions for Respiratory Tract Viral Infections in the Colombian Population

  • Manuel E. Machado-Duque,
  • Diego Arturo García,
  • Melissa Hiromi Emura-Velez,
  • Andrés Gaviria-Mendoza,
  • Claudia Giraldo-Giraldo and
  • Jorge E. Machado-Alba

Antimicrobials are frequently inappropriately prescribed for the management of upper respiratory tract infections (URTIs); therefore, the frequency of antibiotic prescriptions for patients with viral URTIs was assessed in this study. A cross-sectiona...

  • Review
  • Open Access
33 Citations
5,080 Views
12 Pages

Antimicrobial Activity of Calcium Silicate-Based Dental Materials: A Literature Review

  • Ana Cristina Padilha Janini,
  • Gabriela Fernanda Bombarda,
  • Lauter Eston Pelepenko and
  • Marina Angélica Marciano

Endodontic biomaterials have significantly improved dental treatment techniques in several aspects now that they can be used for vital pulp treatments, as temporary intracanal medication, in definitive fillings, in apical surgeries, and for regenerat...

  • Article
  • Open Access
7 Citations
5,121 Views
10 Pages

Assessing Knowledge and Perception Regarding Antimicrobial Stewardship and Antimicrobial Resistance in University Students of Pakistan: Findings and Implications

  • Iltaf Hussain,
  • Nisa Yousaf,
  • Sana Haider,
  • Pervisha Jalil,
  • Muhammad Usman Saleem,
  • Imran Imran,
  • Abdul Majeed,
  • Anees ur Rehman,
  • Muhammad Uzair and
  • Muhammad Fawad Rasool
  • + 2 authors

The irrational use of antimicrobials has enormously contributed to antimicrobial resistance (AMR) globally and especially in the developing world. To assess the knowledge and perception regarding AMR and antimicrobial stewardship (AMS), a descriptive...

  • Article
  • Open Access
8 Citations
4,739 Views
11 Pages

Evaluating the Implementation of a Pilot Quality Improvement Program to Support Appropriate Antimicrobial Prescribing in General Practice

  • Ruby Biezen,
  • Kirsty Buising,
  • Tim Monaghan,
  • Rachael Ball,
  • Karin Thursky,
  • Ron Cheah,
  • Malcolm Clark and
  • Jo-Anne Manski-Nankervis

Inappropriate antimicrobial prescribing contributes to increasing antimicrobial resistance. An antimicrobial stewardship (AMS) program in the form of quality improvement activities that included audit and feedback, clinical decision support and educa...

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Antibiotics - ISSN 2079-6382