Discovery and Biosynthesis of Novel Antibiotic from Streptomyces

Dear Colleagues,

Streptomyces species are well-known industrial bacteria that produce about two-thirds of all medically important secondary metabolites, including compounds of diverse classes of antibiotics.

Unfortunately, during the last 20 years, very few new antibiotics from Streptomyces or other organisms have been detected due to the re-discovery of known compounds, limited abilities to cultivate newly founded species, or narrow knowledge on the regulation and biosynthesis of secondary metabolites. The discovery of novel antibiotics is of great importance due to the increasing number of multi-resistant microbial pathogens, as a result of the uncontrolled application of antibiotics in medicine and agriculture.

Analyses of the genomes of many Streptomyces have revealed that each can contain 20–50 or more biosynthetic gene clusters and many encoded products, which are not associated with any known natural compounds, and, thus, are a real gold mine for the discovery of new potential antibiotics.

This Special Issue will highlight recent developments in genome-based methods and strategies focused on the discovery, analysis, and manipulation of structural and regulatory genes in “orphan” biosynthetic gene clusters, to activate or increase the production of valuable compounds, and also the heterologous expression and application of synthetic biology tools for the discovery of novel antibiotics from Streptomyces. Manuscripts that further our understanding of recent advances in the field of antimicrobial drug discovery from other Actinomycetes are also welcome.

Dr. Olga Sekurova
Guest Editor

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