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Antibiotics, Volume 10, Issue 6

June 2021 - 139 articles

Cover Story: Modern dosing regimens of antibiotics have abandoned the notion of “one-size-fits-all”. Antibiotics have a clear exposure–effect relationship that is causally linked to treatment efficacy. According to their pharmacokinetic (PK) properties, maximizing the ß-lactam exposure can be achieved by increasing the time (T) that the unbound fraction of the drug (f) remains above the pathogen-specific minimal inhibitory concentration (MIC). Extending the ß-lactam infusions is a feasible approach for extending the fT>MIC without a need for regular therapeutic drug monitoring (TDM) of serum concentrations. Recent national and international guidelines favor extended infusions of ß-lactams over intermittent bolus application in critically ill patients. View this paper
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Articles (139)

  • Article
  • Open Access
11 Citations
4,197 Views
13 Pages

Molecular and Anti-Microbial Resistance (AMR) Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) from Hospital and Long-Term Care Facilities (LTCF) Environment

  • Bing-Mu Hsu,
  • Jung-Sheng Chen,
  • I-Ching Lin,
  • Gwo-Jong Hsu,
  • Suprokash Koner,
  • Bashir Hussain,
  • Shih-Wei Huang and
  • Hsin-Chi Tsai

To provide evidence of the cross-contamination of emerging pathogenic microbes in a local network between long-term care facilities (LTCFs) and hospitals, this study emphasizes the molecular typing, the prevalence of virulence genes, and the antibiot...

  • Article
  • Open Access
8 Citations
4,081 Views
9 Pages

National Facilitators and Barriers to the Implementation of Incentives for Antibiotic Access and Innovation

  • Christine Årdal,
  • Yohann Lacotte,
  • Suzanne Edwards,
  • Marie-Cécile Ploy and
  • on behalf of the European Union Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections (EU-JAMRAI)

Prominent reports have assessed the challenges to antibiotic innovation and recommended implementing “pull” incentives, i.e., mechanisms that give increased and predictable revenues for important, marketed antibiotics. We set out to understand countr...

  • Review
  • Open Access
65 Citations
9,825 Views
21 Pages

Evaluation of Microalgae Antiviral Activity and Their Bioactive Compounds

  • Dora Allegra Carbone,
  • Paola Pellone,
  • Carmine Lubritto and
  • Claudia Ciniglia

During the last year, science has been focusing on the research of antivirally active compounds overall after the SARS-CoV-2 pandemic, which caused a great amount of deaths and the downfall of the economy in 2020. Photosynthetic organisms such as mic...

  • Article
  • Open Access
11 Citations
3,333 Views
11 Pages

Fecal Carriage and Epidemiology of Extended-Spectrum Beta-Lactamase/Carbapenemases Producing Enterobacterales Isolates in Bulgarian Hospitals

  • Rumyana Markovska,
  • Petya Stankova,
  • Temenuga Stoeva,
  • Dobrinka Ivanova,
  • Daniela Pencheva,
  • Radka Kaneva and
  • Lyudmila Boyanova

The gastrointestinal tract is an important reservoir of extended spectrum beta-lactamase (ESBL)/carbapenemase-producing Enterobacterales isolates. This study included patients from two Bulgarian hospitals. Overall, 98 ESBL producers (including 68 Esc...

  • Article
  • Open Access
21 Citations
4,395 Views
17 Pages

A New Dermal Substitute Containing Polyvinyl Alcohol with Silver Nanoparticles and Collagen with Hyaluronic Acid: In Vitro and In Vivo Approaches

  • Dario Mendes Júnior,
  • Moema A. Hausen,
  • Jéssica Asami,
  • Akemi M. Higa,
  • Fabio L. Leite,
  • Giovanni P. Mambrini,
  • Andre L. Rossi,
  • Daniel Komatsu and
  • Eliana A. de Rezende Duek

The experimental use of poly (alcohol-vinyl) (PVA) as a skin curative is increasing widely. However, the use of this hydrogel is challenging due to its favorable properties for microbiota growth. The association with silver nanoparticles (AgNPs) as a...

  • Review
  • Open Access
22 Citations
6,337 Views
8 Pages

The treatment of prosthetic joint infections (PJIs) is a complex matter in which surgical, microbiological and pharmacological aspects must be integrated and, above all, placed in the context of each patient to make the best decision. Sometimes it is...

  • Article
  • Open Access
24 Citations
4,642 Views
12 Pages

Antimicrobial-resistance in Enterobacterales is a serious concern in Saudi Arabia. The present study retrospectively analyzed the antibiograms of Enterobacterales identified from 1 January 2019 to 31 December 2019 from a referral hospital in the Aljo...

  • Review
  • Open Access
58 Citations
7,232 Views
14 Pages

Antimicrobial Use in COVID-19 Patients in the First Phase of the SARS-CoV-2 Pandemic: A Scoping Review

  • Wenjuan Cong,
  • Ak Narayan Poudel,
  • Nour Alhusein,
  • Hexing Wang,
  • Guiqing Yao and
  • Helen Lambert

This scoping review provides new evidence on the prevalence and patterns of global antimicrobial use in the treatment of COVID-19 patients; identifies the most commonly used antibiotics and clinical scenarios associated with antibiotic prescribing in...

  • Article
  • Open Access
17 Citations
4,854 Views
15 Pages

Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

  • Marina Pekmezovic,
  • Melina Kalagasidis Krusic,
  • Ivana Malagurski,
  • Jelena Milovanovic,
  • Karolina Stępień,
  • Maciej Guzik,
  • Romina Charifou,
  • Ramesh Babu,
  • Kevin O’Connor and
  • Jasmina Nikodinovic-Runic

Novel biodegradable and biocompatible formulations of “old” but “gold” drugs such as nystatin (Nys) and amphotericin B (AmB) were made using a biopolymer as a matrix. Medium chain length polyhydroxyalkanoates (mcl-PHA) were used to formulate both pol...

  • Article
  • Open Access
40 Citations
6,322 Views
15 Pages

Use of Antimicrobials among Suspected COVID-19 Patients at Selected Hospitals, Bangladesh: Findings from the First Wave of COVID-19 Pandemic

  • Syeda Mah-E-Muneer,
  • Md. Zakiul Hassan,
  • Md. Abdullah Al Jubayer Biswas,
  • Fahmida Rahman,
  • Zubair Akhtar,
  • Pritimoy Das,
  • Md. Ariful Islam and
  • Fahmida Chowdhury

Antimicrobials are empirically used in COVID-19 patients resulting in increased antimicrobial resistance. Our objective was to assess antimicrobial use among suspected COVID-19 in-patients. From March to August 2020, we collected data from in-patient...

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Antibiotics - ISSN 2079-6382