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Antibiotics
Volume 10
Issue 7
10.3390/antibiotics10070863
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Review

Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens

by
Viola Camilla Scoffone
1,
Gabriele Trespidi
1,
Giulia Barbieri
1,
Samuele Irudal
1,
Elena Perrin
2,* and
Silvia Buroni
1,*
1
Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, 27100 Pavia, Italy
2
Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy
*
Authors to whom correspondence should be addressed.
Antibiotics 2021, 10(7), 863; https://doi.org/10.3390/antibiotics10070863
Submission received: 28 May 2021 / Revised: 1 July 2021 / Accepted: 13 July 2021 / Published: 15 July 2021
(This article belongs to the Special Issue The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria)
Versions Notes

Abstract

Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species (Pseudomonas aeruginosa, Burkholderia cenocepacia, Achromobacter xylosoxidans, Stenotrophomonas maltophilia) for which a predominant role of RND pumps has been associated to MDR phenotypes.
Keywords: RND efflux pumps; drug resistance; cystic fibrosis RND efflux pumps; drug resistance; cystic fibrosis

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MDPI and ACS Style

Scoffone, V.C.; Trespidi, G.; Barbieri, G.; Irudal, S.; Perrin, E.; Buroni, S. Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens. Antibiotics 2021, 10, 863. https://doi.org/10.3390/antibiotics10070863

AMA Style

Scoffone VC, Trespidi G, Barbieri G, Irudal S, Perrin E, Buroni S. Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens. Antibiotics. 2021; 10(7):863. https://doi.org/10.3390/antibiotics10070863

Chicago/Turabian Style

Scoffone, Viola Camilla, Gabriele Trespidi, Giulia Barbieri, Samuele Irudal, Elena Perrin, and Silvia Buroni. 2021. "Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens" Antibiotics 10, no. 7: 863. https://doi.org/10.3390/antibiotics10070863

APA Style

Scoffone, V. C., Trespidi, G., Barbieri, G., Irudal, S., Perrin, E., & Buroni, S. (2021). Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens. Antibiotics, 10(7), 863. https://doi.org/10.3390/antibiotics10070863

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