Special Issue "Mechanisms of Antimicrobial Peptides on Pathogens"
Deadline for manuscript submissions: 30 September 2021.
Interests: antimicrobial peptides; peptide synthesis; peptide drug formulation;combination antibiotic therapy; bacterial biofilm; microbial resistance
Antimicrobial peptides (AMPs) are considered as promising alternative for conventional antimicrobials. They are widely distributed in nature as developmental components of the innate immunity of living organisms. The majority of AMPs are cationic, amphipathic molecules that exhibit strong activity against a broad spectrum of pathogens including multi-drug resistant strains. Their ability to eliminate and prevent biofilm structures has been proven in in vitro and in vivo studies.
The most common mode of action of AMPs is disruption of cell membranes leading to microbial lysis. Due to their unique mechanism of action based on interactions with the microbial cell membrane, AMPs can act on slow-growing or even non-growing bacteria and are active against biofilm. This mode has also less risk of acquired resistance or cross-resistance with other agents than other modes of action, which makes it an attractive template for the design of new antimicrobials for specific applications.
Several mechanisms of membrane perturbation are discussed on a molecular level (e.g. toroidal pore formation, the carpet model, void formation, clustering of lipids, and membrane curvature). However, also numerous AMPs with non-conventional modes of action have been described so far. Determination and understanding the modes of action of AMPs are crucial for the rational design of improved antimicrobial compounds.
The aim of this special issue is to extend the scientific knowledge on AMPs in order to examine their modes of action, understand possible mechanims of microbial resistance, explore potential clinical applications and to survey recent achievements in this field of research.
Dr. Malgorzata Paduszynska
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antimicrobial peptides
- mechanisms of antimicrobial activities
- interactions with bacterial membrane
- microbial resistance
- inhibition of biofilm formation
- biofilm eradication