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Antibiotics, Volume 10, Issue 7

July 2021 - 135 articles

Cover Story: Antibiotics have served modern medicine well, but the inexorable trend to resistance poses future challenges. Epidemiological surveillance programs, stewardship, and development of new drugs have collectively met urgent needs to address antibiotic resistance. The report by Villanueva et al. using a CA-MRSA strain, MW2, considered a less studied question: does a bacterium possess mechanisms that actually help it to survive low level exposure with antibiotics (in this case ceftaroline)? Most antibiotics are naturally occurring or derivatives, and so bacteria could possibly have evolved protection against sub-therapeutic concentrations. Identifying if this is the case, and by what mechanism, might help antibiotics work better or lead to promising targets for future adjuvant therapy. Indeed, disruption of two environmental-sensing systems led to dramatically enhanced sensitivity to ceftaroline. View this paper.
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Articles (135)

  • Article
  • Open Access
7 Citations
4,093 Views
13 Pages

Staphylococcal Biofilm on the Surface of Catheters: Electron Microscopy Evaluation of the Inhibition of Biofilm Growth by RNAIII Inhibiting Peptide

  • Adilson de Oliveira,
  • Luiza Pinheiro-Hubinger,
  • Valéria Cataneli Pereira,
  • Danilo Flávio Moraes Riboli,
  • Katheryne Benini Martins,
  • Letícia Calixto Romero and
  • Maria de Lourdes Ribeiro de Souza da Cunha

Staphylococcus aureus and coagulase-negative staphylococci (CoNS) have become the main causative agents of medical device-related infections due to their biofilm-forming capability, which protects them from the host’s immune system and from the actio...

  • Article
  • Open Access
29 Citations
4,764 Views
11 Pages

In Vitro Synergy of Colistin in Combination with Meropenem or Tigecycline against Carbapenem-Resistant Acinetobacter baumannii

  • Jacinda C. Abdul-Mutakabbir,
  • Juwon Yim,
  • Logan Nguyen,
  • Philip T. Maassen,
  • Kyle Stamper,
  • Zain Shiekh,
  • Razieh Kebriaei,
  • Ryan K. Shields,
  • Mariana Castanheira and
  • Keith S. Kaye
  • + 1 author

Acinetobacter baumannii is currently classified as one of six pathogens that contribute to increased patient mortality. Thus, exploratory studies navigating alternative treatment strategies are of supreme interest. Herein, we completed minimum inhibi...

  • Article
  • Open Access
21 Citations
7,189 Views
17 Pages

Occurrence of Rare Pathogens at the Site of Periprosthetic Hip and Knee Joint Infections: A Retrospective, Single-Center Study

  • Konstantinos Anagnostakos,
  • Christoph Grzega,
  • Ismail Sahan,
  • Udo Geipel and
  • Sören L. Becker

The frequency and clinical relevance of rare pathogens at the site of periprosthetic infections of the hip and knee joint and their antibiotic resistance profiles have not yet been assessed in-depth. We retrospectively analyzed all periprosthetic hip...

  • Article
  • Open Access
30 Citations
4,435 Views
12 Pages

The emergence and spread of multidrug-resistant Salmonella enterica (S. enterica) to humans through food of animal origin are considered a major global public health concern. Currently, little is known about the prevalence of important antimicrobial...

  • Article
  • Open Access
49 Citations
10,033 Views
19 Pages

The use of contaminated water has been associated with severe disease outbreaks. Due to widespread pollution with untreated sewage, concerns have been raised over water quality in Lebanon, a country with well-documented challenges in infrastructure....

  • Review
  • Open Access
211 Citations
11,120 Views
23 Pages

Do Iron Oxide Nanoparticles Have Significant Antibacterial Properties?

  • Sergey V. Gudkov,
  • Dmitriy E. Burmistrov,
  • Dmitriy A. Serov,
  • Maksim B. Rebezov,
  • Anastasia A. Semenova and
  • Andrey B. Lisitsyn

The use of metal oxide nanoparticles is one of the promising ways for overcoming antibiotic resistance in bacteria. Iron oxide nanoparticles (IONPs) have found wide applications in different fields of biomedicine. Several studies have suggested using...

  • Article
  • Open Access
15 Citations
5,408 Views
11 Pages

Perspectives of Healthcare Professionals Regarding Factors Associated with Antimicrobial Resistance (AMR) and Their Consequences: A Cross Sectional Study in Eastern Province of Saudi Arabia

  • Mohamed A. Baraka,
  • Amany Alboghdadly,
  • Samar Alshawwa,
  • Asim Ahmed Elnour,
  • Hassan Alsultan,
  • Taha Alsalman,
  • Hussain Alaithan,
  • Md. Ashraful Islam,
  • Kareem Ahmed El-Fass and
  • Yehia Mohamed
  • + 2 authors

Factors reported in the literature associated with inappropriate prescribing of antimicrobials include physicians with less experience, uncertain diagnosis, and patient caregiver influences on physicians’ decisions. Monitoring antimicrobial resistanc...

  • Article
  • Open Access
19 Citations
3,908 Views
12 Pages

MCR Expression Conferring Varied Fitness Costs on Host Bacteria and Affecting Bacteria Virulence

  • Wan Li,
  • Zhihai Liu,
  • Wenjuan Yin,
  • Lu Yang,
  • Lu Qiao,
  • Shikai Song,
  • Zhuoren Ling,
  • Ruicheng Zheng,
  • Congming Wu and
  • Yang Wang
  • + 1 author

Since the first report of the plasmid-mediated, colistin-resistant gene, mcr-1, nine mcr genes and their subvariants have been identified. The spreading scope of mcr-1~10 varies greatly, suggesting that mcr-1~10 may have different evolutionary advant...

  • Perspective
  • Open Access
6 Citations
4,415 Views
8 Pages

Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting

  • Balasubramanian Cibichakravarthy and
  • Polapass Arul Jose

Streptomyces are the most prolific source of structurally diverse microbial natural products. Advancing genome-based analysis reveals the previously unseen potential of Streptomyces to produce numerous novel secondary metabolites, which allows us to...

  • Article
  • Open Access
53 Citations
6,839 Views
18 Pages

Subinhibitory Antibiotic Concentrations Enhance Biofilm Formation of Clinical Enterococcus faecalis Isolates

  • Sara Bernardi,
  • Annette Anderson,
  • Guido Macchiarelli,
  • Elmar Hellwig,
  • Fabian Cieplik,
  • Kirstin Vach and
  • Ali Al-Ahmad

Enterococcus faecalis is a microorganism that can be found in the oral cavity, especially in secondary endodontic infections, with a prevalence ranging from 24–70%. The increase in the ability to form biofilms in the presence of subinhibitory antibio...

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Antibiotics - ISSN 2079-6382