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Biosensors, Volume 16, Issue 1

2026 January - 67 articles

Cover Story: Presented here are flexible, miniaturized inkjet-printed pH sensors designed for lung-on-a-chip integration to enable the study of inhalation products, drug delivery, aerosol–tissue interactions and accompanying pH fluctuations. PVC-based ISE membranes and polyaniline were evaluated on flexible substrates, including screen-printed carbon and inkjet-printed graphene electrodes. A biocompatible polyaniline-modified graphene electrode, paired with an inkjet-printed Ag/AgCl reference electrode, exhibited Nernstian sensitivity (58.8 mV/pH), good reproducibility, reversibility and stability. It was integrated into a lung model with an electrospun polycaprolactone membrane and alginate to mimic the alveolar barrier and mucosal environment. System permeability was assessed by monitoring pH changes induced by introducing an acidic aerosol. View this paper
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Articles (67)

  • Review
  • Open Access
284 Views
32 Pages

Combined Use of Microwave Sensing Technologies and Artificial Intelligence for Biomedical Monitoring and Imaging

  • Andrea Martínez-Lozano,
  • Alejandro Buitrago-Bernal,
  • Langis Roy,
  • José María Vicente-Samper and
  • Carlos G. Juan

22 January 2026

Microwave sensing technology is rapidly advancing and increasingly finding its way into biomedical applications, promising significant improvements for medical care. Concurrently, the rise of artificial intelligence (AI) is enabling significant enhan...

  • Review
  • Open Access
285 Views
37 Pages

Smart Biosensing Nanomaterials for Alzheimer’s Disease: Advances in Design and Drug Delivery Strategies to Overcome the Blood–Brain Barrier

  • Manickam Rajkumar,
  • Furong Tian,
  • Bilal Javed,
  • Bhupendra G. Prajapati,
  • Paramasivam Deepak,
  • Koyeli Girigoswami and
  • Natchimuthu Karmegam

21 January 2026

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by persistent memory impairment and complex molecular and cellular pathological changes in the brain. Current treatments, including acetylcholinesterase inhibitors and...

  • Article
  • Open Access
300 Views
19 Pages

Regulation of Synaptic Plasticity and Adaptive Convergence Under Rhythmic Stimulation of an In Vitro Hippocampal Neuronal Network of Cultured Cells

  • Shutong Sun,
  • Longhui Jiang,
  • Yaoyao Liu,
  • Li Shang,
  • Chengji Lu,
  • Shangchen Li,
  • Kui Zhang,
  • Mixia Wang,
  • Xinxia Cai and
  • Jinping Luo

19 January 2026

Synaptic plasticity constitutes a fundamental mechanism of neural systems. Rhythmic activities (e.g., θ and γ oscillations) play a critical role in modulating network plasticity efficiency in biological neural systems. However, the rules...

  • Review
  • Open Access
749 Views
28 Pages

Yeast Biosensors for the Safety of Fermented Beverages

  • Sílvia Afonso,
  • Ivo Oliveira and
  • Alice Vilela

16 January 2026

Yeast biosensors represent a promising biotechnological innovation for ensuring the safety and quality of fermented beverages such as beer, wine, and kombucha. These biosensors employ genetically engineered yeast strains to detect specific contaminan...

  • Article
  • Open Access
206 Views
12 Pages

16 January 2026

Microparticle detection technology uses materials that can specifically recognize complex biostructures, such as antibodies and aptamers, as trapping agents. The development of antibody production technology and simplification of sensing signal outpu...

  • Review
  • Open Access
468 Views
28 Pages

Two-Dimensional Carbon-Based Electrochemical Sensors for Pesticide Detection: Recent Advances and Environmental Monitoring Applications

  • K. Imran,
  • Al Amin,
  • Gajapaneni Venkata Prasad,
  • Y. Veera Manohara Reddy,
  • Lestari Intan Gita,
  • Jeyaraj Wilson and
  • Tae Hyun Kim

14 January 2026

Pesticides have been widely applied in agricultural practices over the past decades to protect crops from pests and other harmful organisms. However, their extensive use results in the contamination of soil, water, and agricultural products, posing s...

  • Article
  • Open Access
283 Views
22 Pages

A Luminol-Based, Peroxide-Free Fenton Chemiluminescence System Driven by Cu(I)-Polyethylenimine-Lipoic Acid Nanoflowers for Ultrasensitive SARS-CoV-2 Immunoassay

  • Mahmoud El-Maghrabey,
  • Ali Abdel-Hakim,
  • Yuta Matsumoto,
  • Rania El-Shaheny,
  • Heba M. Hashem,
  • Naotaka Kuroda and
  • Naoya Kishikawa

14 January 2026

The reliance on unstable hydrogen peroxide (H2O2) adversely affects the robustness and simplicity of chemiluminescence (CL)-based immunoassays. We report a novel external H2O2-free Fenton CL system integrated into a highly sensitive non-enzymatic imm...

  • Article
  • Open Access
394 Views
24 Pages

Surface-Imprinted Polymer Coupled with Diffraction Gratings for Low-Cost, Label-Free and Differential E. coli Detection

  • Dua Özsoylu,
  • Elke Börmann-El-Kholy,
  • Rabia N. Kaya,
  • Patrick Wagner and
  • Michael J. Schöning

13 January 2026

Surface-imprinted polymer (SIP)-based biomimetic sensors are promising for direct whole-bacteria detection; however, the commonly used fabrication approach (micro-contact imprinting) often suffers from limited imprint density, heterogeneous template...

  • Article
  • Open Access
286 Views
18 Pages

Real-Time Monitoring of Microbial Contamination and Stress Biomarkers with Liquid Crystal-Based Immunosensors for Food Safety Assessment

  • Maria Simone Soares,
  • Andreia C. M. Rodrigues,
  • Sílvia. F. S. Pires,
  • Amadeu M. V. M. Soares,
  • Ana P. L. Costa,
  • Jan Nedoma,
  • Pedro L. Almeida,
  • Nuno Santos and
  • Carlos Marques

13 January 2026

Aquaculture is a crucial global food production sector that faces challenges in water quality management, food safety, and stress-related health concerns in aquatic species. Cortisol, a key stress biomarker in fish, and Escherichia coli (E. coli) con...

  • Review
  • Open Access
295 Views
45 Pages

Advancements in Machine Learning-Assisted Flexible Electronics: Technologies, Applications, and Future Prospects

  • Hao Su,
  • Hongcun Wang,
  • Dandan Sang,
  • Santosh Kumar,
  • Dao Xiao,
  • Jing Sun and
  • Qinglin Wang

13 January 2026

The integration of flexible electronics and machine learning (ML) algorithms has become a revolutionary force driving the field of intelligent sensing, giving rise to a new generation of intelligent devices and systems. This article provides a system...

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Biosensors - ISSN 2079-6374