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Biosensors
Special Issues
Biosensors for Personalized Treatment
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Biosensors for Personalized Treatment

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (15 April 2026) | Viewed by 5232

Special Issue Editors

Prof. Dr. Tianling Ren

E-Mail Website
Guest Editor
School of Integrated Circuits, Tsinghua University, Beijing 100084, China
Interests: advanced manufacturing technologies and micro/nanomaterials; intelligent sensors and systems; information devices and integrated circuits
Dr. Luqi Tao

E-Mail Website
Guest Editor
1. School of Integrated Circuits, Tsinghua University, Beijing 100084, China
2. Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing 100084, China
Interests: 2D materials and devices; flexible sensors for healthcare applications; wearable devices and intelligent systems

Special Issue Information

Dear Colleagues,

Recent advances in biosensor technology have opened new frontiers in personalized healthcare, enabling more precise, individualized treatment approaches. This Special Issue focuses on the latest developments in biosensor technologies that facilitate personalized treatment strategies. We welcome contributions that explore novel biosensor designs, fabrication techniques, and system integration approaches aimed at advancing personalized medicine. Topics of interest include, but are not limited to, the following: flexible and wearable biosensors for continuous health monitoring, 2D material-based biosensing platforms, MEMS/NEMS biosensors, smart sensor systems for real-time health data analysis, integrated biosensor chips for point-of-care diagnostics, and advanced manufacturing processes for next-generation biosensors. We particularly encourage submissions that address the challenges of developing reliable, sensitive, and user-friendly biosensor systems that can support personalized treatment decisions. This Special Issue aims to showcase cutting-edge research that bridges the gap between innovative biosensor technologies and their practical applications in personalized healthcare delivery.

Prof. Dr. Tianling Ren
Dr. Luqi Tao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • flexible biosensors
  • 2D material-based sensors
  • wearable health monitoring
  • integrated sensing systems
  • smart medical devices
  • point-of-care diagnostics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

37 pages, 7246 KB  
Review
Wearable Sensing Systems for Multi-Modal Body Fluid Monitoring: Sensing-Combination Strategy, Platform-Integration Mechanism, and Data-Processing Pattern
by Manqi Peng, Yuntong Ning, Jiarui Zhang, Yuhang He, Zigan Xu, Ding Li, Yi Yang and Tian-Ling Ren
Biosensors 2026, 16(1), 46; https://doi.org/10.3390/bios16010046 - 6 Jan 2026
Cited by 4 | Viewed by 2118
Abstract
Wearable multi-modal body fluid monitoring enables continuous, non-invasive, and context-aware assessment of human physiology. By integrating biochemical and physical information across multiple modalities, wearable systems overcome the limitations of single-marker sensing and provide a more holistic view of dynamic health states. This review [...] Read more.
Wearable multi-modal body fluid monitoring enables continuous, non-invasive, and context-aware assessment of human physiology. By integrating biochemical and physical information across multiple modalities, wearable systems overcome the limitations of single-marker sensing and provide a more holistic view of dynamic health states. This review offers a system-level overview of recent advances in multi-modal body fluid monitoring, structured into three hierarchical dimensions. We first examine sensing-combination strategies such as multi-marker analysis within single fluids, coupling biochemical signals with bioelectrical, mechanical, or thermal parameters, and emerging multi-fluid acquisition to improve analytical accuracy and physiological relevance. Next, we discuss platform-integration mechanisms based on biochemical, physical, and hybrid sensing principles, along with monolithic and modular architectures enabled by flexible electronics, microfluidics, microneedles, and smart textiles. Finally, the data-processing patterns are analyzed, involving cross-modal calibration, machine learning inference, and multi-level data fusion to enhance data reliability and support personalized and predictive healthcare. Beyond summarizing technical advances, this review establishes a comprehensive framework that moves beyond isolated signal acquisition or simple metric aggregation toward holistic physiological interpretation. It guides the development of next-generation wearable multi-modal body fluid monitoring systems that overcome the challenges of high integration, miniaturization, and personalized medical applications. Full article
(This article belongs to the Special Issue Biosensors for Personalized Treatment)
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27 pages, 1664 KB  
Review
Actomyosin-Based Nanodevices for Sensing and Actuation: Bridging Biology and Bioengineering
by Nicolas M. Brunet, Peng Xiong and Prescott Bryant Chase
Biosensors 2025, 15(10), 672; https://doi.org/10.3390/bios15100672 - 4 Oct 2025
Cited by 1 | Viewed by 2493
Abstract
The actomyosin complex—nature’s dynamic engine composed of actin filaments and myosin motors—is emerging as a versatile tool for bio-integrated nanotechnology. This review explores the growing potential of actomyosin-powered systems in biosensing and actuation applications, highlighting their compatibility with physiological conditions, responsiveness to biochemical [...] Read more.
The actomyosin complex—nature’s dynamic engine composed of actin filaments and myosin motors—is emerging as a versatile tool for bio-integrated nanotechnology. This review explores the growing potential of actomyosin-powered systems in biosensing and actuation applications, highlighting their compatibility with physiological conditions, responsiveness to biochemical and physical cues and modular adaptability. We begin with a comparative overview of natural and synthetic nanomachines, positioning actomyosin as a uniquely scalable and biocompatible platform. We then discuss experimental advances in controlling actomyosin activity through ATP, calcium, heat, light and electric fields, as well as their integration into in vitro motility assays, soft robotics and neural interface systems. Emphasis is placed on longstanding efforts to harness actomyosin as a biosensing element—capable of converting chemical or environmental signals into measurable mechanical or electrical outputs that can be used to provide valuable clinical and basic science information such as functional consequences of disease-associated genetic variants in cardiovascular genes. We also highlight engineering challenges such as stability, spatial control and upscaling, and examine speculative future directions, including emotion-responsive nanodevices. By bridging cell biology and bioengineering, actomyosin-based systems offer promising avenues for real-time sensing, diagnostics and therapeutic feedback in next-generation biosensors. Full article
(This article belongs to the Special Issue Biosensors for Personalized Treatment)
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