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Biosensors
Special Issues
Recent Developments in Nanomaterial-Based Electrochemical Biosensors
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Recent Developments in Nanomaterial-Based Electrochemical Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1675

Special Issue Editor

Dr. Fei Yan

E-Mail Website
Guest Editor
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, China
Interests: porous materials; electrochemical/electrochemiluminescence sensors; anti-fouling determination; POCT; mass transport in nanochannels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Electrochemical biosensors are bioanalytical devices that combine biological components with an electrochemical transducer to detect and quantify various targets. Biological recognition elements in biosensors include antibody/antigen, aptamers and enzymes. According to the signal property, electrochemical biosensors can be classified as amperometric biosensors, electrochemical impedance biosensors, electrochemiluminescence biosensors and photoelectrochemical sensors. By recording the electrochemical change of electrode interfaces, electrochemical biosensors have been widely used in various fields, including medical diagnostics, environmental monitoring and food safety.

Due to their high surface area, excellent conductivity, easy functionalization, good biocompatibility and antifouling property, nanomaterials have emerged as powerful electrode modifiers for the construction of highly efficient electrochemical biosensors in terms of improved sensitivity and selectivity, showing great potential in the field of clinical samples analysis (e.g., serum, whole blood, urine and tissue). With remarkable achievements in nanotechnology, numerous nanomaterials have aroused interest in the fields of quantitative analysis, such as graphene, carbon nanotube, metal nanoparticles, metal organic frameworks, molecular imprinted polymers, quantum dots and so on. Moreover, simultaneous detection of multiple targets, miniaturization of sensors or exploitation of smart techniques are highly desired for practical application.

This Special Issue aims to report the recent developments and advances in nanomaterial-based electrochemical biosensors. We welcome the submission of original research, reviews, mini reviews and perspective articles on the above themes.

Dr. Fei Yan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • electrochemical biosensors
  • clincial samples anaysis
  • portable detection
  • small molecule metabolites
  • pharmaceutical analysis
  • pathogen detection
  • toxin analysis biomarkers detection

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Published Papers (2 papers)

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Research

16 pages, 1900 KiB  
Article
Experimental and in Silico Studies on the Development of an Electrochemical Biosensor for the Quantification of H2O2 Based on the ChOx Enzyme
by Elvis Ortiz-Santos, Gabriela Valdés-Ramírez, Cesar Millán-Pacheco, Iris N. Serratos, Maria Luisa Lozano-Camargo, Pablo Dalmasso, Gustavo A. Rivas and Laura Galicia
Biosensors 2025, 15(5), 279; https://doi.org/10.3390/bios15050279 - 29 Apr 2025
Abstract
This work presents the development of a biosensing platform for hydrogen peroxide (H2O2) electrochemical reduction. The developed platform uses a multi-walled carbon nanotube paste (PMWCNT) and the enzyme cholesterol oxidase (ChOx). The supramolecular architecture of the PMWCNT/ChOx platform was [...] Read more.
This work presents the development of a biosensing platform for hydrogen peroxide (H2O2) electrochemical reduction. The developed platform uses a multi-walled carbon nanotube paste (PMWCNT) and the enzyme cholesterol oxidase (ChOx). The supramolecular architecture of the PMWCNT/ChOx platform was characterized using cyclic voltammetry, electrochemical impedance spectroscopy, and amperometry. The results indicated that the presence of ChOx enhances the sensitivity of electrochemical detection for H2O2 by 21 times compared to that without ChOx. The designed electrochemical sensing bio-platform for H2O2 shows a sensitivity of 26.15 µA/mM in the linear range from 0.4 to 4.0 mM, an LOD of 0.43 µM, and an LOQ of 1.31 µM. Furthermore, in silico studies (molecular dynamics simulations, molecular docking assays, and binding free energy calculations (ΔGb)) were carried out to characterize and validate the molecular interaction between ChOx and H2O2. The computed data confirmed that the binding is spontaneous, and the type of labile interaction promotes a rapid electrochemical reduction of H2O2. Full article
(This article belongs to the Special Issue Recent Developments in Nanomaterial-Based Electrochemical Biosensors)
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19 pages, 2617 KiB  
Article
An Antimicrobial and Antifibrotic Coating for Implantable Biosensors
by Sofia Wareham-Mathiassen, Pawan Jolly, Nandhinee Radha Shanmugam, Badrinath Jagannath, Pranav Prabhala, Yunhao Zhai, Alican Ozkan, Arash Naziripour, Rohini Singh, Henrik Bengtsson, Thomas Bjarnsholt and Donald E. Ingber
Biosensors 2025, 15(3), 171; https://doi.org/10.3390/bios15030171 - 6 Mar 2025
Viewed by 1377
Abstract
Biofouling and foreign body responses have deleterious effects on the functionality and longevity of implantable biosensors, seriously impeding their implementation for long-term monitoring. Here, we describe a nanocomposite coating composed of a cross-linked lattice of bovine serum albumin and pentaamine-functionalized reduced graphene that [...] Read more.
Biofouling and foreign body responses have deleterious effects on the functionality and longevity of implantable biosensors, seriously impeding their implementation for long-term monitoring. Here, we describe a nanocomposite coating composed of a cross-linked lattice of bovine serum albumin and pentaamine-functionalized reduced graphene that is covalently coupled to antibody ligands for analyte detection as well as antibiotic drugs (gentamicin or ceftriaxone), which actively combats biofouling while retaining high electroconductivity and excellent electrochemical immunosensor behavior. Sensors overlaid with this coating inhibit the proliferation of Pseudomonas aeruginosa bacteria and adhesion of primary human fibroblasts while not having any significant effects on fibroblast viability or on the immune function of primary human monocytes. Under these conditions, the sensor maintains its electrochemical stability for at least 3 weeks after exposure to soluble proteins that interfere with the activity of uncoated sensors. Proof-of-concept for the coating’s applicability is demonstrated by integrating the antimicrobial coating within an immunosensor and demonstrating the detection of cytokines in both culture medium and complex human plasma. This new coating technology holds the potential to substantially increase the lifespan of implanted biosensors and widen their application areas, potentially enabling continuous monitoring of analytes in complex biofluids for weeks in vivo. Full article
(This article belongs to the Special Issue Recent Developments in Nanomaterial-Based Electrochemical Biosensors)
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