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Journal of Clinical Medicine, Volume 9, Issue 9

September 2020 - 380 articles

Cover Story: Plasma exchange and immunoadsorption constitute two different extracorporeal methods of apheresis which are frequently used in a large variety of neuroinflammatory diseases. Immunoadsorption is more selective and is generally considered advantageous with regard to safety in tolerability. However, our data show the importance of not only considering the choice of method, but also specific treatment regimens. By lowering the volume of exchanged plasma per day, we were able to significantly reduce the frequency of adverse events in plasma exchange, both compared to previous publications as well as compared to immunoadsorption. Efficacy of this approach must however be proven in future studies. View this paper.
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Articles (380)

  • Review
  • Open Access
71 Citations
15,812 Views
19 Pages

The Role of Thermal Water in Chronic Skin Diseases Management: A Review of the Literature

  • Sara Cacciapuoti,
  • Maria A. Luciano,
  • Matteo Megna,
  • Maria C. Annunziata,
  • Maddalena Napolitano,
  • Cataldo Patruno,
  • Emanuele Scala,
  • Roberta Colicchio,
  • Chiara Pagliuca and
  • Paola Salvatore
  • + 1 author

22 September 2020

The benefits of thermal water in different diseases have been known since ancient times. Over the past decades, a re-assessment of the use of mineral water for the treatment of several pathologic conditions has taken place around the world. Today, wa...

  • Article
  • Open Access
8 Citations
2,841 Views
13 Pages

Novel Sub-Clustering of Class III Skeletal Malocclusion Phenotypes in a Southern European Population Based on Proportional Measurements

  • Leixuri de Frutos-Valle,
  • Conchita Martín,
  • José Antonio Alarcón,
  • Juan Carlos Palma-Fernández,
  • Ricardo Ortega and
  • Alejandro Iglesias-Linares

22 September 2020

Current phenotypic characterizations of Class III malocclusion are influenced more by gender or ethnic origin than by raw linear skeletal measurements. The aim of the present research is to develop a Class III skeletal malocclusion sub-phenotype char...

  • Review
  • Open Access
20 Citations
3,472 Views
16 Pages

Precision Medicine to Treat Advanced Gastroesophageal Adenocarcinoma: A Work in Progress

  • Valentina Gambardella,
  • Tania Fleitas,
  • Noelia Tarazona,
  • Federica Papaccio,
  • Marisol Huerta,
  • Susana Roselló,
  • Francisco Gimeno-Valiente,
  • Desamparados Roda and
  • Andrés Cervantes

22 September 2020

Gastroesophageal adenocarcinoma (GEA) represents a heterogeneous disease and, when diagnosed as locally advanced or metastatic, it is characterized by poor prognosis. During the last few years, several molecular classifications have been proposed to...

  • Article
  • Open Access
3 Citations
2,992 Views
13 Pages

Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation

  • Zsuzsa Bagoly,
  • Orsolya Hajas,
  • Réka Urbancsek,
  • Alexandra Kiss,
  • Edit Fiak,
  • Ferenc Sarkady,
  • Noémi Klára Tóth,
  • Rita Orbán-Kálmándi,
  • Kitti Bernadett Kovács and
  • László Nagy
  • + 4 authors

22 September 2020

Background. Cerebral thromboembolism is a rare but feared complication of transcatheter ablation in patients with atrial fibrillation (AF). Here, we aimed to test which pre-procedural anticoagulation strategy results in less intracardiac activation o...

  • Article
  • Open Access
16 Citations
3,505 Views
15 Pages

Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension

  • Mark Lipphardt,
  • Hassan Dihazi,
  • Jens-Holger Maas,
  • Ann-Kathrin Schäfer,
  • Saskia I. Amlaz,
  • Brian B. Ratliff,
  • Michael J. Koziolek and
  • Manuel Wallbach

22 September 2020

(1) Background: Arterial hypertension (HTN) is one of the most relevant cardiovascular risk factors. Nowadays multiple pharmaceutical treatment options exist with novel interventional methods (e.g., baroreflex activation therapy (BAT)) as a last reso...

  • Article
  • Open Access
20 Citations
4,213 Views
12 Pages

Monomeric C-Reactive Protein Aggravates Secondary Degeneration after Intracerebral Haemorrhagic Stroke and May Function as a Sensor for Systemic Inflammation

  • Mark Slevin,
  • Elisa García-Lara,
  • Bogdan Capitanescu,
  • Coral Sanfeliu,
  • Yasmin Zeinolabediny,
  • Raid AlBaradie,
  • Peter Olah,
  • Baoqiang Guo,
  • Daniel Pirici and
  • Mario Di Napoli
  • + 1 author

22 September 2020

Background: We previously identified increased tissue localization of monomeric C-reactive protein (mCRP) in the infarcted cortical brain tissue of patients following ischaemic stroke. Here, we investigated the relationship of mCRP expression in haem...

  • Article
  • Open Access
8 Citations
3,010 Views
12 Pages

Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal

  • Antonello E. Rigamonti,
  • Sofia Tamini,
  • Sabrina Cicolini,
  • Alessandra De Col,
  • Diana Caroli,
  • Stefania Mai,
  • Eugenia Rondinelli,
  • Antonella Saezza,
  • Silvano G. Cella and
  • Alessandro Sartorio

22 September 2020

Proteins have been demonstrated to reduce food intake in animals and humans via peripheral and central mechanisms. Supplementation of a dietetic regimen with single or mixed amino acids might represent an approach to improve the effectiveness of any...

  • Article
  • Open Access
11 Citations
3,442 Views
13 Pages

Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features

  • Álvaro Flores-Martinez,
  • Eva Venegas-Moreno,
  • Elena Dios,
  • Pablo Remón-Ruiz,
  • Noelia Gros-Herguido,
  • M. Carmen Vázquez-Borrego,
  • Ainara Madrazo-Atutxa,
  • Miguel A. Japón,
  • Ariel Kaen and
  • Eugenio Cárdenas-Valdepeñas
  • + 5 authors

22 September 2020

The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery, but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for somatostatin (SST1-5) and dopamine (DRDs) providing a rationale for the use o...

  • Article
  • Open Access
27 Citations
4,681 Views
14 Pages

22 September 2020

Background: Limited available evidence suggests that a small proportion of inpatients undergo prolonged hospitalization and use a disproportionate number of bed days. Understanding the factors contributing to prolonged hospitalization may improve pat...

  • Article
  • Open Access
4 Citations
2,820 Views
13 Pages

Characterization of Fetal Thyroid Levels at Delivery among Appalachian Infants

  • Madison N. Crank,
  • Jesse N. Cottrell,
  • Brenda L. Mitchell and
  • Monica A. Valentovic

22 September 2020

Thyroid disorders are a frequently encountered issue during pregnancy and a cause of maternal and fetal morbidity. In regions like Appalachia that are particularly susceptible to health disparities, descriptive studies are needed to assist in identif...

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J. Clin. Med. - ISSN 2077-0383