Cardiovascular and Renal Damage in Hypertension: Prognostic Role and a Guide for Treatment
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 24680
Special Issue Editor
Special Issue Information
Dear Colleagues,
The prevalence of hypertension (HT) in adults is around 30%–45% worldwide and becomes progressively higher with advancing age. Furthermore, HT is often associated with many highly prevalent comorbidities such as obesity, diabetes, and chronic kidney disease (CKD).
In addition to the severity of blood pressure (BP) increase and systemic hemodynamic load, there are other clinical variables that strongly influence the risk of acute and chronic complications in patients with HT. Among these concomitant conditions, the presence of so-called hypertension-mediated organ damage (HMOD) at the cardiac renal and vascular level plays a strong role in long-term clinical outcomes. Furthermore, there is clear evidence that other mediators (hyperuricemia, metabolic syndrome, hyperlipidemia, mineral bone disease, etc.) are also crucially involved in the transition from a healthy to a diseased state of target organs.
The clinical relevance of HMOD detection is due to the fact that it is not only a marker of elevated BP, but also an important predictor of CV events and, above all, changes in its severity are an important modulator of overall prognosis. This has obvious consequences for a multifactorial approach aimed not only at achieving target BP levels but also at preventing the development or the progression of HMOD in order to optimally reduce the overall cardiovascular risk for patients.
This review will thus focus on several aspects of HMOD in different clinical settings, with a particular attention to mechanisms of its development, noninvasive tools useful in its detection and to multifactorial therapeutic strategies aimed at reducing CV and renal risk.
Prof. Dr. Francesca Chiara Viazzi
Guest Editor
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Keywords
- Blood pressure behavior
- Resistant hypertension
- Diabetes
- Chronic kidney disease
- Serum uric acid
- Albuminuria
- Left ventricular hypertrophy
- Vascular stiffness
- Renin–angiotensin–aldosterone system
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