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Experimental Dental Research—New Concepts for Future Patient Needs

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 45697

Special Issue Editor


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Guest Editor
Universitätsklinikum des Saarlandes und Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany
Interests: biomechanics of dental implants; strategies for disinfection; attachment systems for removable dental prostheses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In many dental subspecialties, high levels of success and predictability have been reached, enabling clinicians to provide adequate treatment in the vast majority of cases. The current literature seems to strongly focus on clinical reports comparing different treatment options for our current patient population. In many instances, the already high levels of success can hardly be improved and sometimes the questions arises whether or not a relevant question exists as a basis for such studies. Not to be misunderstood—there can be no doubt that clinical data is highly relevant for us as treatment providers, for our patients and for quality assurance.

On the opposite side, for experimental research in the preclinical stage and also for novel ideas which might result in new treatment strategies in the future, it is becoming increasingly difficult to get published. For advancing the art and science of dentistry, such studies—if following sound scientific principles—may be considered as being of greater value as compared to clinical studies applying concepts and products which are already available today.

This Special Issue intends to provide room for new concepts, new ideas, and new products which will help to address the future needs of our patients.

Prof. Dr. Matthias Karl
Guest Editor

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Keywords

  • preclinical research
  • new concepts
  • operative dentistry
  • prosthodontics
  • oral surgery

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Published Papers (13 papers)

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Research

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15 pages, 6779 KiB  
Article
An Osteotomy Tool That Preserves Bone Viability: Evaluation in Preclinical and Clinical Settings
by Oded Bahat, Xing Yin, Stefan Holst, Ion Zabalegui, Eva Berroeta, Javier Pérez, Peter Wöhrle, Norbert Sörgel, John Brunski and Jill A. Helms
J. Clin. Med. 2022, 11(9), 2536; https://doi.org/10.3390/jcm11092536 - 30 Apr 2022
Cited by 7 | Viewed by 2646
Abstract
The main objectives of this work were to assess the efficiency, ease-of-use, and general performance of a novel osseoshaping tool based on first-user clinical experiences and to compare these observations with preclinical data generated in rodents using a miniaturized version of the instrument. [...] Read more.
The main objectives of this work were to assess the efficiency, ease-of-use, and general performance of a novel osseoshaping tool based on first-user clinical experiences and to compare these observations with preclinical data generated in rodents using a miniaturized version of the instrument. All patients selected for the surgery presented challenging clinical conditions in terms of the quality and/or quantity of the available bone. The presented data were collected during the implant placement of 15 implants in 7 patients, and included implant recipient site (bone quality and quantity) and ridge evaluation, intra-operative handling of the novel instrument, and the evaluation of subsequent implant insertion. The instrument was easy to handle and was applied without any complications during the surgical procedure. Its use obviated the need for multiple drills and enabled adequate insertion torque in all cases. This biologically driven innovation in implant site preparation shows improvements in preserving vital anatomical and cellular structures as well as simplifying the surgical protocol with excellent ease-of-use and handling properties. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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12 pages, 2119 KiB  
Article
Differences in the Buccal Bone Marrow Distance of ≤0.8 mm in the Mandible of Patients Undergoing Sagittal Split Ramus Osteotomy among the Different Skeletal Patterns: A Retrospective Study
by Yu-Chuan Tseng, Shih-Wei Liang, Szu-Ting Chou, Shih-Chieh Chen, Chin-Yun Pan and Chun-Ming Chen
J. Clin. Med. 2021, 10(23), 5644; https://doi.org/10.3390/jcm10235644 - 30 Nov 2021
Viewed by 1919
Abstract
This study investigated the relationship between the thickness of the ramus and skeletal patterns using cone-beam computed tomography (CBCT) for sagittal split ramus osteotomy. Ninety participants were categorized into three skeletal patterns (Class I, Class II, and Class III). The first vertical slice [...] Read more.
This study investigated the relationship between the thickness of the ramus and skeletal patterns using cone-beam computed tomography (CBCT) for sagittal split ramus osteotomy. Ninety participants were categorized into three skeletal patterns (Class I, Class II, and Class III). The first vertical slice (slice 0) was observed in the intact mandibular canal, and then moved forward to 40 mm (slice 21) with a 2 mm interval. The thickness of buccal bone marrow (B value) was measured. A B value of ≤0.8 mm was considered to be the major risk factor causing the occurrence of postoperative lower lip paresthesia. There were 461 sides with a B value of ≤0.8 mm. There was a significant difference in the skeletal patterns [Class III (198 sides: 15.7%) > Class I (159 sides: 12.6%) > Class II (104 sides: 8.3%)]. Class II participants had significantly larger B values (2.14 to 3.76 mm) and a lower occurrence rate (≤0.8 mm) than those of Class III participants (1.5 to 3 mm) in front of the mandibular foramen (from 6 mm to 20 mm). Class III participants had significantly shorter buccal bone marrow distance and a higher occurrence rate of B values (≤0.8 mm) than Class II. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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10 pages, 5199 KiB  
Article
Minimal Dentinal Tubule Penetration of Endodontic Sealers in Warm Vertical Compaction by Direct Detection via SEM Analysis
by Sina Schmidt, Edgar Schäfer, Sebastian Bürklein, Arno Rohrbach and David Donnermeyer
J. Clin. Med. 2021, 10(19), 4440; https://doi.org/10.3390/jcm10194440 - 27 Sep 2021
Cited by 5 | Viewed by 2807
Abstract
Sealer staining using rhodamine B dye to investigate the penetration depth of endodontic sealers was proven unsuitable for this purpose. This study aimed to investigate the sealer penetration depth into dentinal tubules by scanning electron microscopy (SEM). Root canals of 52 human upper [...] Read more.
Sealer staining using rhodamine B dye to investigate the penetration depth of endodontic sealers was proven unsuitable for this purpose. This study aimed to investigate the sealer penetration depth into dentinal tubules by scanning electron microscopy (SEM). Root canals of 52 human upper central incisors were instrumented using the ProTaper Gold NiTi system (Dentsply Sirona, York, PA, USA) up to size F3. After irrigation with sodium hypochlorite and citric acid combined with ultrasonic activation, the root canals were either filled using the epoxy resin sealer AH Plus (Dentsply Sirona) or the calcium silicate-based sealer Total Fill BC Sealer HiFlow (TFHF, FKG Dentaire, La Chaux-de-Fonds, Switzerland) by warm vertical compaction. Root slices of 1 mm thickness were obtained at 2 to 3, 5 to 6 and 8 to 9 mm from the apex. The root slices were investigated for sealer penetration into the dentinal tubules using SEM according to four root quadrants (buccal, mesial, oral, distal). Statistical analysis was performed by the Kruskal-Wallis test (p = 0.05) as data were not normally distributed according to the Shapiro-Wilk test. AH Plus penetrated significantly deeper into the dentinal tubules compared to TFHF at each root level (p < 0.05). Dentinal sealer penetration was deeper in the bucco-oral direction compared to the mesio-distal direction. AH Plus penetrated deeper into dentinal tubules than TFHF. Warm vertical compaction exerting high pressure on the root canal filling material is not able to press sealers deep into dentinal tubules as penetration depth values did not exceed a mean of 110 µm in SEM. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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17 pages, 2228 KiB  
Article
A Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus: A Split-Mouth Randomised Controlled Study
by Jacek Zborowski, Dorota Kida, Aleksandra Szarwaryn, Karol Nartowski, Patrycja Rak, Kamil Jurczyszyn and Tomasz Konopka
J. Clin. Med. 2021, 10(16), 3673; https://doi.org/10.3390/jcm10163673 - 19 Aug 2021
Cited by 9 | Viewed by 3198
Abstract
Background: The aim of the study was to compare the effectiveness of photodynamic therapy (PDT) to steroid therapy in the treatment of oral lichen planus (OLP). Due to the lack of commercially available drug carriers, innovative proprietary solutions were used for both the [...] Read more.
Background: The aim of the study was to compare the effectiveness of photodynamic therapy (PDT) to steroid therapy in the treatment of oral lichen planus (OLP). Due to the lack of commercially available drug carriers, innovative proprietary solutions were used for both the photosensitiser and the steroid carrier—in the first case to shorten and in the second to extend the contact of the active substance with the mucosa. Methods: A prospective, randomised, single-blind, 12-week full contralateral split-mouth clinical trial of 30 patients with bilateral oral lichen planus was conducted. The prepared matrices were incorporated with active substances methylene blue 5% and 0,05% triamcinolone. The size of lesions, Thongprasom, ABISIS, and VAS scale were evaluated. Results: Relatively high rates of complete remission of lichen were demonstrated: immediately after treatment, 33.3% with PDT and 22.2% with triamcinolone (TA), and after 3 months, 54.2% with PDT and 62.9% with TA. After 3 months of treatment, a reduction in the area of evaluated lesions of 52.7% for PDT and 41.7% for TA was achieved. Conclusion: In situations of topical or general contraindications to oral corticosteroids, resistance to them, or the need for repeated treatment in a short period of time, PDT appears to be a very promising treatment option. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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13 pages, 22705 KiB  
Article
Influence of an Implant Fixture including a Freely Removable Micro-Locking Implant Prosthesis on Peri-Implant Tissues and Implant Prostheses: A Prospective Clinical Study
by Young-Gun Shin, Won-Tak Cho, Ho-Kyung Lim, Su-Hyun Hwang, Ji-Hyeon Bae, Gang-Ho Bae, Jeong-Yol Lee and Jung-Bo Huh
J. Clin. Med. 2021, 10(15), 3321; https://doi.org/10.3390/jcm10153321 - 28 Jul 2021
Cited by 5 | Viewed by 2176
Abstract
This prospective study was undertaken to evaluate the clinical usefulness of a newly developed one-piece, screw-free, and micro-locking implant system, which was designed to overcome the shortcomings of the existing implant systems. Thirty-eight patients were recruited and randomly and equally assigned to an [...] Read more.
This prospective study was undertaken to evaluate the clinical usefulness of a newly developed one-piece, screw-free, and micro-locking implant system, which was designed to overcome the shortcomings of the existing implant systems. Thirty-eight patients were recruited and randomly and equally assigned to an experimental group (micro-locking one-piece fixture, MLF; n = 19) or a control group (micro-locking abutment, MLA). Cumulative implant survival rates, marginal bone resorptions, probing depths, plaque indices, bleeding indices, and complications were obtained by using clinical and radiographic findings at 6 months and 12 months after prosthesis placement. Complications that occurred multiple times for single implants were counted. During the 12 month observation period, survival rates were 100% in both groups. No significant intergroup differences were observed for marginal bone resorption, probe depth, or bleeding index. However, mean plaque index was significantly lower in the MLF group at 12 months (p < 0.05). During the 12-month observation period, food impaction (26.3%) was the main complication in the MLF group and screw loosening (5.3%), prosthesis detachment (5.3%), and food impaction (5.3%) were observed in the MLA group. The results of this study suggest that the one-piece micro-locking implant system offers a predictable treatment method. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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19 pages, 2443 KiB  
Article
New Rehabilitation Concept for Maxillary Edentulism: A Clinical Retrospective Study of Implant Crown Retained Removable Partial Dentures
by Soo-Yeon Yoo, Seong-Kyun Kim, Seong-Joo Heo, Jai-Young Koak and Hye-Rin Jeon
J. Clin. Med. 2021, 10(8), 1773; https://doi.org/10.3390/jcm10081773 - 19 Apr 2021
Cited by 9 | Viewed by 6251
Abstract
There have been no studies of implant-crown-retained removable partial dentures (IC-RPD) for the treatment of maxillary edentulism. The purpose of this study was to perform clinical and radiographic evaluations of implants in IC-RPD compared to implant overdentures (IOD) in maxillary edentulous patients. Twenty [...] Read more.
There have been no studies of implant-crown-retained removable partial dentures (IC-RPD) for the treatment of maxillary edentulism. The purpose of this study was to perform clinical and radiographic evaluations of implants in IC-RPD compared to implant overdentures (IOD) in maxillary edentulous patients. Twenty IC-RPDs with 74 splinted implant crowns and 18 IODs with 71 implants retained with magnet attachments were observed in 38 patients. We statistically analyzed survival rates and marginal bone loss (MBL) of implants based on multiple variables including first year pathologic condition, location of placed implant, age, and sex in both treatments. Patient reported oral measurements (PROMs) regarding functional/esthetic improvement after IC-RPD or IOD treatments and prosthetic complications were also statistically analyzed. After a median observation period of 47.1 months (up to 147 months), we observed 97.3% implant survival rates for IC-RPD and 70.4% for IOD (p < 0.001). Among variables, first year pathologic condition (p < 0.001) and sex (p = 0.027) influenced implant survival rates. The MBL of implants for IC-RPD and IOD groups at the final check-up were 1.12 ± 1.19 mm and 3.31 ± 1.71 mm, respectively (p < 0.001). In both groups, patients with peri-implantitis (p < 0.001) and patients older than 65 years (p = 0.029) showed significantly higher implant MBL regardless of treatment modality. Functional and esthetic satisfaction were significantly improved (p < 0.001) after both treatments. The IOD group showed more frequent prosthetic complications compared to the IC-RPD group. Within the limitations of a retrospective study, we concluded that RPD with few splinted implant crowns is a feasible alternative treatment modality for maxillary edentulous patients with anatomical limitations. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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13 pages, 19409 KiB  
Article
The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath
by Vuk Savkovic, Hanluo Li, Danilo Obradovic, Federica Francesca Masieri, Alexander K. Bartella, Rüdiger Zimmerer, Jan-Christoph Simon, Christian Etz and Bernd Lethaus
J. Clin. Med. 2021, 10(5), 911; https://doi.org/10.3390/jcm10050911 - 26 Feb 2021
Cited by 9 | Viewed by 3188
Abstract
Neovascularization is regarded as a pre-requisite in successful tissue grafting of both hard and soft tissues alike. This study considers mesenchymal stem cells from hair follicle outer root sheath (MSCORS) as powerful tools with a neat angiogenic potential that could in the future [...] Read more.
Neovascularization is regarded as a pre-requisite in successful tissue grafting of both hard and soft tissues alike. This study considers mesenchymal stem cells from hair follicle outer root sheath (MSCORS) as powerful tools with a neat angiogenic potential that could in the future have wide scopes of neo-angiogenesis and tissue engineering. Autologous MSCORS were obtained ex vivo by non-invasive plucking of hair and they were differentiated in vitro into both endothelial cells and vascular smooth muscle cells (SMCs), two crucial cellular components of vascular grafts. Assessment was carried out by immunostaining, confocal laser-scanning microscopy, gene expression analysis (qRT-PCR), quantitative analysis of anastomotic network parameters, and cumulative length quantification of immunostained α-smooth muscle actin-containing stress fibers (α -SMA). In comparison to adipose mesenchymal stem cells, MSCORS exhibited a significantly higher differentiation efficiency according to key quantitative criteria and their endothelial derivatives demonstrated a higher angiogenic potential. Furthermore, the cells were capable of depositing their own extracellular matrix in vitro in the form of a membrane-cell sheet, serving as a base for viable co-culture of endothelial cells and SMCs integrated with their autologous matrix. Differentiated MSCORS hereby provided a complex autologous cell-matrix construct that demonstrates vascularization capacity and can serve as a base for personalized repair grafting applications. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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15 pages, 7636 KiB  
Article
Clinical Studies Regarding Electromagnetic Stimulation in Proximity of Dental Implants on Patients with/without Orthodontic Treatment
by Eugen-Silviu Bud, Anamaria Bud, Mariana Păcurar, Alexandru Vlasa, Ana Petra Lazăr and Luminita Lazăr
J. Clin. Med. 2020, 9(12), 3983; https://doi.org/10.3390/jcm9123983 - 9 Dec 2020
Cited by 1 | Viewed by 1785
Abstract
As a result of the loss of a tooth, there is a decrease in trabecular bone and loss of height and width of the adjacent bone. This study was designed as an observational imaging study, regarding structural changes that may occur during healing [...] Read more.
As a result of the loss of a tooth, there is a decrease in trabecular bone and loss of height and width of the adjacent bone. This study was designed as an observational imaging study, regarding structural changes that may occur during healing after the placement of Titanium dental implants. For this purpose, Cone Beam Computed Tomography was used in order to determine bone modifications around dental implants, loaded either with conventional healing caps or with healing caps pulsating electromagnetic waves, Magdent™, Haifa, Israel. The mean age of the study population was 49.84 ± 3.29 years (95% confidence interval (CI): 46.55−53.13). According to the voxel measurements after conventional treatment, there was a significant difference p < 0.0001 between bone radiodensity before treatment 288.1 ± 47.16 Standard Deviation (SD), and bone radiodensity 688.1 ± 81.02 SD after treatment with conventional healing caps. According to the voxel measurements after treatment with MagdentMed™ pulse electromagnetic healing caps, there was a significant difference p < 0.0001 between bone radiodensity before treatment 310.7 ± 53.26 SD and bone radiodensity after treatment with MED caps 734 ± 61.96 SD. The most common result of our study was a slightly higher radiodensity nearest the interface of dental implants after treatment. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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15 pages, 4173 KiB  
Article
Pilot Study on the Use of a Laser-Structured Double Diamond Electrode (DDE) for Biofilm Removal from Dental Implant Surfaces
by Maximilian Koch, Andreas Burkovski, Manuel Zulla, Stefan Rosiwal, Walter Geißdörfer, Roman Dittmar and Tanja Grobecker-Karl
J. Clin. Med. 2020, 9(9), 3036; https://doi.org/10.3390/jcm9093036 - 21 Sep 2020
Cited by 9 | Viewed by 3337
Abstract
No proper treatment option for peri-implantitis exists yet. Based on previous studies showing the in vitro effectiveness of electrochemical disinfection using boron-doped diamond electrodes, novel double diamond electrodes (DDE) were tested here. Using a ceramic carrier and a laser structuring process, a clinically [...] Read more.
No proper treatment option for peri-implantitis exists yet. Based on previous studies showing the in vitro effectiveness of electrochemical disinfection using boron-doped diamond electrodes, novel double diamond electrodes (DDE) were tested here. Using a ceramic carrier and a laser structuring process, a clinically applicable electrode array was manufactured. Roughened metal discs (n = 24) made from Ti-Zr alloy were exposed to the oral cavities of six volunteers for 24 h in order to generate biofilm. Then, biofilm removal was carried out either using plastic curettes and chlorhexidine digluconate or electrochemical disinfection. In addition, dental implants were contaminated with ex vivo multispecies biofilm and disinfected using DDE treatment. Bacterial growth and the formation of biofilm polymer were determined as outcome measures. Chemo-mechanical treatment could not eliminate bacteria from roughened surfaces, while in most cases, a massive reduction of bacteria and biofilm polymer was observed following DDE treatment. Electrochemical disinfection was charge- and time-dependent and could also not reach complete disinfection in all instances. Implant threads had no negative effect on DDE treatment. Bacteria exhibit varying resistance to electrochemical disinfection with Bacillus subtilis, Neisseria sp., Rothiamucilaginosa, Staphylococcus haemolyticus, and Streptococcus mitis surviving 5 min of DDE application at 6 V. Electrochemical disinfection is promising but requires further optimization with respect to charge quantity and application time in order to achieve disinfection without harming host tissue. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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7 pages, 1752 KiB  
Article
Evaluation of Insertion Energy as Novel Parameter for Dental Implant Stability
by Tanja Grobecker-Karl, Anthony Dickinson, Siegfried Heckmann, Matthias Karl and Constanze Steiner
J. Clin. Med. 2020, 9(9), 2977; https://doi.org/10.3390/jcm9092977 - 15 Sep 2020
Viewed by 1668
Abstract
Insertion energy has been advocated as a novel measure for primary implant stability, but the effect of implant length, diameter, or surgical protocol remains unclear. Twenty implants from one specific bone level implant system were placed in layered polyurethane foam measuring maximum insertion [...] Read more.
Insertion energy has been advocated as a novel measure for primary implant stability, but the effect of implant length, diameter, or surgical protocol remains unclear. Twenty implants from one specific bone level implant system were placed in layered polyurethane foam measuring maximum insertion torque, torque–time curves, and primary stability using resonance frequency analysis (RFA). Insertion energy was calculated as area under torque–time curve applying the trapezoidal formula. Statistical analysis was based on analysis of variance, Tukey honest differences tests and Pearson’s product moment correlation tests (α = 0.05). Implant stability (p = 0.01) and insertion energy (p < 0.01) differed significantly among groups, while maximum insertion torque did not (p = 0.17). Short implants showed a significant decrease in implant stability (p = 0.01), while reducing implant diameter did not cause any significant effect. Applying the drilling protocol for dense bone resulted in significantly increased insertion energy (p = 0.02) but a significant decrease in implant stability (p = 0.04). Insertion energy was not found to be a more reliable parameter for evaluating primary implant stability when compared to maximum insertion torque and resonance frequency analysis. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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Review

Jump to: Research

27 pages, 1592 KiB  
Review
The Influence of New Bioactive Materials on Pulp–Dentin Complex Regeneration in the Assessment of Cone Bone Computed Tomography (CBCT) and Computed Micro-Tomography (Micro-CT) from a Present and Future Perspective—A Systematic Review
by Mirona Paula Palczewska-Komsa, Bartosz Gapiński and Alicja Nowicka
J. Clin. Med. 2022, 11(11), 3091; https://doi.org/10.3390/jcm11113091 - 30 May 2022
Cited by 5 | Viewed by 2758
Abstract
The present paper is the first article providing a systematic literature review on the visualization of tertiary dentin influenced by modern bioactive materials in CBCT and micro-CT. Six database searches of studies on tertiary dentin visualization using CBCT produced 622 records in total, [...] Read more.
The present paper is the first article providing a systematic literature review on the visualization of tertiary dentin influenced by modern bioactive materials in CBCT and micro-CT. Six database searches of studies on tertiary dentin visualization using CBCT produced 622 records in total, and the search of the studies on tertiary dentin using micro-CT produced 502 records in total. The results were thoroughly selected considering the inclusion criteria, and five research papers using CBCT and nine research papers using micro-CT for visualization of tertiary dentin were eventually qualified for the analysis. All the non-randomized and randomized studies presented good and high levels of quality evidence, respectively. Among the bioactive materials used, the most frequently analysed were: MTA, Biodentine dentin matrix hydrogel, Pro Root MTA, and EndoSequence root repair material. The highest thickness of the tertiary dentin was achieved after the use of MTA material in both imaging techniques. The remaining parameters had different results, taking into account the CBCT and micro-CT analysis. The possibilities of the qualitative and quantitative assessment of the particular parameters of tertiary dentin using CBCT and micro-CT techniques were presented and analysed. CBCT and micro-CT analyses can be useful in the assessment of tertiary dentin formed beneath the bioactive material applied during vital pulp treatment. The research argues that the presented results differ depending on the material applied to the pulp, the study duration (4–6 weeks), difference in teeth, species (rats, human), as well as the applied technique and differences in computer software used for the analysis. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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19 pages, 1261 KiB  
Review
Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives
by Valentin Herber, Begüm Okutan, Georgios Antonoglou, Nicole G. Sommer and Michael Payer
J. Clin. Med. 2021, 10(9), 1842; https://doi.org/10.3390/jcm10091842 - 23 Apr 2021
Cited by 36 | Viewed by 5037
Abstract
Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic [...] Read more.
Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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8 pages, 4377 KiB  
Review
Polyoxymethylene as Material for Removable Partial Dentures—A Literature Review and Illustrating Case Report
by Oliver Schierz, Leonie Schmohl, Sebastian Hahnel and Angelika Rauch
J. Clin. Med. 2021, 10(7), 1458; https://doi.org/10.3390/jcm10071458 - 2 Apr 2021
Cited by 4 | Viewed by 5884
Abstract
Compared to thermoplastic manufacturing techniques, computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies make it easier to process modern restorative and prosthetic materials with improved material properties. In dentistry, tooth-colored alternatives to metal-based frameworks for application in removable dental prostheses (RDP) emerged. With [...] Read more.
Compared to thermoplastic manufacturing techniques, computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies make it easier to process modern restorative and prosthetic materials with improved material properties. In dentistry, tooth-colored alternatives to metal-based frameworks for application in removable dental prostheses (RDP) emerged. With regard to this aspect, the current article provides an overview of the specific material properties of polyoxymethylene (POM). Furthermore, it reviews scientific literature indexed in PubMed and Web of Science that focuses on RDPs fabricated from POM within the last 10 years. Finally, a prosthetic rehabilitation of a patient with a RDP fabricated from POM is illustrated and observations during a follow-up over 10 months are described. Scientific data and clinical observations indicate that polyoxymethylene is a promising material that bridges gaps in dental therapeutic options. While survival time may be limited due to wear, POM might be a favorable option for application in semi-permanent restorations. Full article
(This article belongs to the Special Issue Experimental Dental Research—New Concepts for Future Patient Needs)
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