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Vaccines, Volume 10, Issue 12

December 2022 - 205 articles

Cover Story: Although heterologous prime–boost vaccinations potentially augment the immune response against SARS-CoV-2, data among liver transplant (LT) recipients are limited. We assessed humoral and cellular immune responses after primary vaccination and booster doses in LT recipients who received homologous (ChAdOx1/BNT162b2) or heterologous (ChAdOx1/ChAdOx1) vaccinations. We observed a decreased immune response three months post primary vaccination. The booster significantly improved immune responses. Most LT recipients exhibited strong immunity against the wild-type strains; however, the neutralising activity against Omicron variants was substantially lower in both groups despite the booster vaccination. Additional strategies may be required to protect against the Omicron variant in LT recipients to mitigate the ongoing SARS-CoV-2 pandemic. View this paper
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Articles (205)

  • Article
  • Open Access
2 Citations
2,250 Views
13 Pages

Serological Responses up to 9 Months following COVID-19 mRNA Vaccination in Residents and Health-Care Workers of Long-Term Care Facilities: A Multicenter Prospective Cohort Study in Northern Italy

  • Costanza Vicentini,
  • Carla Maria Zotti,
  • Alessandro Roberto Cornio,
  • Jacopo Garlasco,
  • Noemi Marengo,
  • Davide Meddis,
  • Savina Ditommaso,
  • Monica Giacomuzzi,
  • Gabriele Memoli and
  • Valerio Bordino
  • + 2 authors

19 December 2022

Long-term care facilities (LTCFs) were severely affected by COVID-19, in particular in Northern Italy. We aimed to assess antibody responses among residents and healthcare workers (HCWs) of 13 LTCFs through serum samples collected at three time point...

  • Article
  • Open Access
7 Citations
3,164 Views
9 Pages

Prone Positioning: A Safe and Effective Procedure in Pregnant Women Presenting with Severe Acute Respiratory Distress Syndrome

  • Gilmar de Souza Osmundo,
  • Cristiane de Freitas Paganotti,
  • Rafaela Alkmin da Costa,
  • Thiago Henrique dos Santos Silva,
  • Paula Carolina Bombonati,
  • Luiz Marcelo Sa Malbouisson and
  • Rossana Pulcineli Vieira Francisco

19 December 2022

Prone positioning (PP) improves oxygenation and survival in patients with severe acute respiratory distress syndrome (ARDS). Data regarding feasibility and effectiveness of PP in pregnancy are lacking. This subgroup analysis of a cohort study that in...

  • Article
  • Open Access
18 Citations
3,896 Views
22 Pages

Efficacy of a Novel Multiepitope Vaccine Candidate against Foot-and-Mouth Disease Virus Serotype O and A

  • W. A. Gayan Chathuranga,
  • Chamith Hewawaduge,
  • N. A. Nadeeka Nethmini,
  • Tae-Hwan Kim,
  • Ju Hun Kim,
  • Young-Hoon Ahn,
  • In-Joong Yoon,
  • Sung-Sik Yoo,
  • Jong-Hyeon Park and
  • Jong-Soo Lee

19 December 2022

Foot-and-mouth disease (FMD) is a highly contagious and economically devastating disease in cloven-hoofed animals. To prevent the spread of FMD virus (FMDV), traditional inactivated vaccines are used to immunize susceptible animals in disease-endemic...

  • Review
  • Open Access
23 Citations
5,190 Views
15 Pages

Effectiveness of COVID-19 Vaccines against SARS-CoV-2 Omicron Variant (B.1.1.529): A Systematic Review with Meta-Analysis and Meta-Regression

  • Nando Reza Pratama,
  • Ifan Ali Wafa,
  • David Setyo Budi,
  • Henry Sutanto,
  • Tri Pudy Asmarawati,
  • Gema Barlian Effendi and
  • Citrawati Dyah Kencono Wungu

19 December 2022

Vaccine effectiveness (VE) and the urgency of booster vaccination against SARS-CoV-2 Omicron variant need evaluation. A systematic search was conducted from 1–6 April, 2022. VE difference (VED) estimates were assessed using random-effects and m...

  • Article
  • Open Access
2 Citations
2,474 Views
9 Pages

19 December 2022

Background: Outbreaks of small ruminant morbillivirus (SRMV) are regularly occurring in Pakistan despite vaccine availability. This study was designed to identify substitutions within the immunogenic structural and functional regions of the nucleocap...

  • Article
  • Open Access
3 Citations
3,273 Views
9 Pages

Protective Efficacy of Inactivated H9N2 Vaccine in Turkey Poults under Both Experimental and Field Conditions

  • Wael K. Elfeil,
  • Hefny Youssef,
  • Ahmed Sedeek,
  • Ahmed El-Shemy,
  • Ehab M. Abd-Allah,
  • Magdy F. Elkady,
  • Eman K. El_Sayed,
  • Abdel-Hamid I. Bazid and
  • Mona S. Abdallah

19 December 2022

Low pathogenic avian influenza (LPAI) H9N2 virus is one of the major poultry pathogens associated with severe economic losses in the poultry industry (broiler, layers, breeders, and grandparents’ flocks), especially in endemic regions including...

  • Article
  • Open Access
2 Citations
2,166 Views
13 Pages

Endothelial Monocyte-Activating Polypeptide-II Is an Indicator of Severity and Mortality in COVID-19 Patients

  • Manal Mohamed Saber,
  • Azhar Mohamed Nomair,
  • Ashraf M. Osman,
  • Hanan Mohamed Nomeir and
  • Naglaa M. Farag

19 December 2022

Data for predicting the severity and mortality of coronavirus disease 2019 (COVID-19) are limited, and investigations are ongoing. Endothelial monocyte-activating protein II (EMAP-II) is a multifunctional polypeptide with pro-inflammatory properties....

  • Article
  • Open Access
4 Citations
2,592 Views
13 Pages

Neutralizing Antibody and T-Cell Responses against SARS-CoV-2 Wild-Type and Variants of Concern in Chronic Obstructive Pulmonary Disease Subjects after ChAdOx-1/ChAdOx-1 Homologous Vaccination: A Preliminary Study

  • Warawut Chaiwong,
  • Nuchjira Takheaw,
  • Witida Laopajon,
  • Supansa Pata,
  • Pilaiporn Duangjit,
  • Juthamas Inchai,
  • Chaicharn Pothirat,
  • Chaiwat Bumroongkit,
  • Athavudh Deesomchok and
  • Theerakorn Theerakittikul
  • + 8 authors

18 December 2022

Data on immunogenicity of adenovirus-vectored vaccine in chronic obstructive pulmonary disease (COPD) patients is limited. Therefore, we aimed to determine the humoral and cellular immune responses after homologous ChAdOx-1 vaccination in subjects wi...

  • Article
  • Open Access
7 Citations
3,296 Views
9 Pages

A Sandwich ELISA for Quality Control of PCV2 Virus-like Particles Vaccine

  • Mingxia Sun,
  • Shanghui Wang,
  • Zheng Fang,
  • Man Zhao,
  • Yanfei Gao,
  • Tongqing An,
  • Yabin Tu,
  • Haiwei Wang and
  • Xuehui Cai

18 December 2022

Porcine circovirus type 2 (PCV2) is a highly prevalent virus in pig farms worldwide that causes significant economic losses in the swine industry. The PCV2 virus-like particles (VLPs) are potent subunit vaccines that are widely used. Currently, the a...

  • Article
  • Open Access
6 Citations
6,030 Views
12 Pages

17 December 2022

Although neurological complications after the administration of vaccines against coronavirus disease 2019 (COVID-19) are rare, they might result in long-term morbidity. This study was designed to determine the risk of peripheral nervous system (PNS)...

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Vaccines - ISSN 2076-393X