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Antioxidants, Volume 6, Issue 3 (September 2017)
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Cover Story (view full-size image) Pulmonary hypertension has long been associated with the increased production of reactive oxygen [...] Read more. Pulmonary hypertension has long been associated with the increased production of reactive oxygen and nitrogen species (ROS, RNS). The mechanisms leading to the overproduction of ROS and RNS, and how they influence pathological vascular remodeling remain topics of intense investigation. Herein, we summarize past and recent discoveries into the roles of the NADPH oxidases and nitric oxidase synthases in pulmonary hypertension and how they work individually and collectively to influence pulmonary endothelial and smooth muscle cell behavior. View this paper