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Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine?

Ursuline College, Pepper Pike, OH 44121, USA
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Antioxidants 2017, 6(3), 45; https://doi.org/10.3390/antiox6030045
Received: 1 May 2017 / Revised: 19 June 2017 / Accepted: 21 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
For the last two decades, it has been hotly debated whether vitamin E—the major lipid-soluble antioxidant, which functions to maintain neurological integrity—is efficacious as a therapy for Alzheimer’s disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial. However, with the advent of new genetic technologies and identifications of vitamin E-modulating single nucleotide polymorphisms (SNPs), we propose that clinical trials addressing the question “Is vitamin E an effective treatment for Alzheimer’s disease” should consider a more focused and personalized medicine approach to designing experiments. An individual’s naturally-occurring SNP variants may indeed influence vitamin E’s therapeutic effect on Alzheimer’s disease. View Full-Text
Keywords: vitamin E; oxidative stress; Alzheimer’s disease; SNPs; personalized medicine vitamin E; oxidative stress; Alzheimer’s disease; SNPs; personalized medicine
MDPI and ACS Style

Cervantes, B.; Ulatowski, L.M. Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine? Antioxidants 2017, 6, 45.

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