Next Article in Journal
Chemical Analysis of Astragali Complanati Semen and Its Hypocholesterolemic Effect Using Serum Metabolomics Based on Gas Chromatography-Mass Spectrometry
Next Article in Special Issue
Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate
Previous Article in Journal
Attenuation of Red Blood Cell Storage Lesions with Vitamin C
Previous Article in Special Issue
Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
Antioxidants 2017, 6(3), 56;

NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease

Heart Research Institute, Sydney 2042, Australia
Sydney Medical School, the University of Sydney, Sydney 2006, Australia
Author to whom correspondence should be addressed.
Received: 29 May 2017 / Revised: 7 July 2017 / Accepted: 9 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
Full-Text   |   PDF [739 KB, uploaded 12 July 2017]   |  


Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg. A potential approach for treatment is to stimulate the formation of new blood vessels to restore blood flow to limb tissues. This is a process called angiogenesis and involves the proliferation, migration, and differentiation of endothelial cells. Angiogenesis can be stimulated by reactive oxygen species (ROS), with NADPH oxidases (NOX) being a major source of ROS in endothelial cells. This review summarizes the recent evidence implicating NOX isoforms in their ability to regulate angiogenesis in vascular endothelial cells in vitro, and in PAD in vivo. Increasing our understanding of the involvement of the NOX isoforms in promoting therapeutic angiogenesis may lead to new treatment options to slow or reverse PAD. View Full-Text
Keywords: angiogenesis; peripheral artery disease (PAD); NADPH oxidases (NOX); endothelial cell (EC) angiogenesis; peripheral artery disease (PAD); NADPH oxidases (NOX); endothelial cell (EC)

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Manuneedhi Cholan, P.; Cartland, S.P.; Kavurma, M.M. NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease. Antioxidants 2017, 6, 56.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top