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Antioxidants, Volume 12, Issue 10

October 2023 - 111 articles

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Cover Story: Oxidative stress in the RPE/retina has a critical role in the pathogenesis of AMD. Paraoxonase 2 (PON2) is an antioxidant protein with lactonase activity. We show that PON2 is expressed in hRPE cells including mitochondria and is regulated by stress. Knockdown of PON2 causes mitochondrial dysfunction by altering mitochondrial bioenergetics. NaIO3-induced stress causes significant retinal damage and function, which is exacerbated in PON2-deficient mice. Our findings suggest that PON2 may play a beneficial role in the pathophysiology of retinal diseases. View this paper

Articles (111)

  • Article
  • Open Access
8 Citations
2,400 Views
16 Pages

Microencapsulation of Chilean Papaya Waste Extract and Its Impact on Physicochemical and Bioactive Properties

  • Yihajara Fuentes,
  • Claudia Giovagnoli-Vicuña,
  • Mario Faúndez and
  • Ady Giordano

23 October 2023

The microencapsulation of bioactive extracts of Chilean papaya waste, including both seeds and skin, was investigated. Papaya waste extract microcapsules utilizing maltodextrin at 10% (MD10), 20% (MD20), and 30% (MD30) (w/v) as the wall material thro...

  • Article
  • Open Access
11 Citations
3,204 Views
17 Pages

Anti-Wrinkling Effect of 3,4,5-tri-O-caffeoylquinic Acid from the Roots of Nymphoides peltata through MAPK/AP-1, NF-κB, and Nrf2 Signaling in UVB-Irradiated HaCaT Cells

  • Tae-Young Kim,
  • No-June Park,
  • Beom-Geun Jo,
  • Bum Soo Lee,
  • Min-Ji Keem,
  • Taek-Hwan Kwon,
  • Ki Hyun Kim,
  • Su-Nam Kim and
  • Min Hye Yang

23 October 2023

Nymphoides peltata has been widely used pharmacologically in traditional Chinese medicine to treat heat strangury and polyuria. The aim of this study was to isolate the bioactive components from N. peltata and evaluate their potential use as antioxid...

  • Review
  • Open Access
6 Citations
3,050 Views
34 Pages

23 October 2023

Thyroid cancer (TC), the most frequent malignancy of the endocrine system, has recorded an increasing incidence in the last decades. The etiology of TC remains at least partly unknown and, among modifiable risk factors, the gut microbiota and dietary...

  • Article
  • Open Access
27 Citations
2,909 Views
19 Pages

Effects of Extraction Process Factors on the Composition and Antioxidant Activity of Blackthorn (Prunus spinosa L.) Fruit Extracts

  • Ana-Maria Drăghici-Popa,
  • Aurelian Cristian Boscornea,
  • Ana-Maria Brezoiu,
  • Ștefan Theodor Tomas,
  • Oana Cristina Pârvulescu and
  • Raluca Stan

23 October 2023

This study aimed at establishing the optimal conditions for the classic extraction of phenolic compounds from Prunus spinosa L. fruits. The effects of different parameters, i.e., ethanol concentration in the extraction solvent (mixture of ethanol and...

  • Article
  • Open Access
7 Citations
2,862 Views
25 Pages

23 October 2023

Amyotrophic lateral sclerosis (ALS) is a fatal rare disease of progressive degeneration of motor neurons. The most common genetic mutation in ALS is the hexanucleotide repeat expansion (HRE) located in the first intron of the C9orf72 gene (C9-ALS). H...

  • Article
  • Open Access
4 Citations
2,542 Views
15 Pages

Light Quality Potentiates the Antioxidant Properties of Brassica rapa Microgreen Extracts against Oxidative Stress and DNA Damage in Human Cells

  • Ida Paolillo,
  • Giulia Costanzo,
  • Antonella Delicato,
  • Filippo Villano,
  • Carmen Arena and
  • Viola Calabrò

23 October 2023

Plants are an inexhaustible source of bioactive compounds beneficial for contrasting oxidative stress, leading to many degenerative pathologies. Brassica rapa L. subsp. rapa is well known for its nutraceutical properties among edible vegetable specie...

  • Review
  • Open Access
20 Citations
5,469 Views
27 Pages

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

  • Angélica Saraí Jiménez-Osorio,
  • Elizabeth Carreón-Torres,
  • Emmanuel Correa-Solís,
  • Julieta Ángel-García,
  • José Arias-Rico,
  • Octavio Jiménez-Garza,
  • Lizbeth Morales-Castillejos,
  • Hugo Alexander Díaz-Zuleta,
  • Rosa María Baltazar-Tellez and
  • María Luisa Sánchez-Padilla
  • + 2 authors

23 October 2023

Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pre...

  • Article
  • Open Access
11 Citations
3,535 Views
17 Pages

β-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation

  • Jonathan Paulo Agnes,
  • Barbara dos Santos,
  • Raquel Nascimento das Neves,
  • Vitória Maria Marques Luciano,
  • Larissa Benvenutti,
  • Fernanda Capitanio Goldoni,
  • Roberta Giusti Schran,
  • José Roberto Santin,
  • Nara Lins Meira Quintão and
  • Alfeu Zanotto-Filho

22 October 2023

Peripheral neuropathy is an important adverse effect caused by some chemotherapeutic agents, including oxaliplatin (OXA). OXA-induced peripheral neuropathy (OIPN) is a challenging condition due to diagnostic complexities and a lack of effective treat...

  • Article
  • Open Access
17 Citations
6,637 Views
31 Pages

The Potential of Mangifera indica L. Peel Extract to Be Revalued in Cosmetic Applications

  • Abigail García-Villegas,
  • Álvaro Fernández-Ochoa,
  • Alejandro Rojas-García,
  • María Elena Alañón,
  • David Arráez-Román,
  • María de la Luz Cádiz-Gurrea and
  • Antonio Segura-Carretero

21 October 2023

The constant growth of the cosmetic industry, together with the scientific evidence of the beneficial properties of phytochemicals, has generated great interest in the incorporation of bioactive extracts in cosmetic formulations. This study aims to e...

  • Article
  • Open Access
3,075 Views
18 Pages

Effects of Dendropanax morbiferus Leaf Extract on Sleep Parameters in Invertebrate and Vertebrate Models

  • Kayoung Ko,
  • Yejin Ahn,
  • Ga Yeong Cheon,
  • Hyung Joo Suh,
  • Yun Jae Cho,
  • Sung-Soo Park and
  • Ki-Bae Hong

21 October 2023

Dendropanax morbiferus is highly valued in traditional medicine and has been used to alleviate the symptoms of numerous diseases owing to its excellent antioxidant activity. This study aimed to evaluate the sleep promotion and related signaling pathw...

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