Table of Contents
Brain Sci., Volume 8, Issue 1 (January 2018)
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Cover Story (view full-size image) The cover image shows the viability and cell death of cerebellar granule neurons (CGN) (cyan arrow) [...] Read more. The cover image shows the viability and cell death of cerebellar granule neurons (CGN) (cyan arrow) and astrocytes (red arrow) treated with cerebrospinal fluid (CSF) of Multiple Sclerosis (MS) patients. The CSF of MS patients contain some factors that may have caused selective cell death in CGN. We discuss that those factors may induce cell death by downregulated expression of genes involved in glucose metabolism and ATP production in these CSF-treated neurons. The CSF effect differs according to MS severity; it is higher in relapsing MS with oligoclonal IgG and IgM bands (G+/M+ RMS) and spinal MS, which may be related to their differential restoration capacity of neuronal damage between MS subtypes of patients.View the paper here.