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Brain Sciences, Volume 8, Issue 1

January 2018 - 19 articles

Cover Story: The cover image shows the viability and cell death of cerebellar granule neurons (CGN) (cyan arrow) and astrocytes (red arrow) treated with cerebrospinal fluid (CSF) of Multiple Sclerosis (MS) patients. The CSF of MS patients contain some factors that may have caused selective cell death in CGN. We discuss that those factors may induce cell death by downregulated expression of genes involved in glucose metabolism and ATP production in these CSF-treated neurons. The CSF effect differs according to MS severity; it is higher in relapsing MS with oligoclonal IgG and IgM bands (G+/M+ RMS) and spinal MS, which may be related to their differential restoration capacity of neuronal damage between MS subtypes of patients.View the paper here.
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Articles (19)

  • Review
  • Open Access
8 Citations
7,548 Views
15 Pages

22 January 2018

The treatment of obesity and eating disorders such as binge-eating disorder or anorexia nervosa is challenging. Besides lifestyle changes and pharmacological options, bariatric surgery represents a well-established and effective-albeit invasive-treat...

  • Review
  • Open Access
18 Citations
6,606 Views
5 Pages

DBS in Treatment of Post-Traumatic Stress Disorder

  • Angelo Lavano,
  • Giusy Guzzi,
  • Attilio Della Torre,
  • Serena Marianna Lavano,
  • Raffaele Tiriolo and
  • Giorgio Volpentesta

20 January 2018

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested and deep brain stimulation (DBS) is currently under investigation for patie...

  • Review
  • Open Access
51 Citations
7,139 Views
10 Pages

19 January 2018

Advancements in neuroimaging have led to a trend toward direct, image-based targeting under general anesthesia without the use of microelectrode recording (MER) or intraoperative test stimulation, also referred to as “asleep” deep brain stimulation (...

  • Review
  • Open Access
105 Citations
9,912 Views
13 Pages

Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

  • Mayra Paolillo,
  • Cinzia Boselli and
  • Sergio Schinelli

16 January 2018

Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with classical alkylating agents such as temozolomide offer little hope to escape a poor prognosis. For these reasons, enormous e...

  • Article
  • Open Access
10 Citations
5,584 Views
19 Pages

16 January 2018

The aim of this study is to examine and compare the depression symptoms pattern and social correlates in three groups: foreign-born Chinese Americans, US-born Chinese Americans, and non-Hispanic whites. This study used data from the Collaborative Psy...

  • Case Report
  • Open Access
4 Citations
5,941 Views
7 Pages

Blood Flow and Continuous EEG Changes during Symptomatic Plateau Waves

  • Natalie Kreitzer,
  • Maggie Huynh and
  • Brandon Foreman

12 January 2018

Benign meningiomas uncommonly lead to significant cerebral edema, with only a few cases previously reported in the medical literature. The present study describes the case of a 49-year-old female who had a meningioma resection. She subsequently devel...

  • Case Report
  • Open Access
2 Citations
7,377 Views
8 Pages

The authors present a unique case of recurrent stroke, discovered to be secondary to hemorrhagic conversion of microemboli from a mechanical aortic valve despite anticoagulation with Coumadin. The complexity of this case was magnified by the patient’...

  • Article
  • Open Access
34 Citations
8,364 Views
11 Pages

Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury

  • Saurav Bhowmick,
  • Veera D‘Mello,
  • Nizmi Ponery and
  • P. M. Abdul Muneer

Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused b...

  • Review
  • Open Access
32 Citations
8,412 Views
14 Pages

Background: Child neglect is highly prevalent and associated with a series of biological and social consequences. Early neglect may alter the recognition of emotional faces, but its precise impact remains unclear. We aim to review and analyze data fr...

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Brain Sci. - ISSN 2076-3425