Next Article in Journal
Stimulation and Neuromodulation in the Treatment of Epilepsy
Previous Article in Journal
Advances in Brain Tumor Surgery for Glioblastoma in Adults
Previous Article in Special Issue
Alzheimer’s Disease Early Diagnosis Using Manifold-Based Semi-Supervised Learning
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Brain Sci. 2018, 8(1), 1; doi:10.3390/brainsci8010001

Disturbed Glucose Metabolism in Rat Neurons Exposed to Cerebrospinal Fluid Obtained from Multiple Sclerosis Subjects

Department of Functional Biology, University of Valencia, 46100 Valencia, Spain
Multiple Sclerosis Laboratory, Department of Biomedicine, Prince Felipe Research Center, 46012 Valencia, Spain
CSUR-Esclerosi Múltiple, Hospital Universitari i Politècnic La Fe, Unitat Mixta d’Esclerosi Múltiple i Neurorregeneració de l’IIS-La Fe, 46026 València, Spain
Department of Biochemistry and Molecular Biology, University of Valencia and INCLIVA Biomedical Research Institute, 46100 Valencia, Spain
Hospital Clínico, Universitario de Valencia, 46010 Valencia, Spain
Deceased 15 March 2017 (in loving memory).
Author to whom correspondence should be addressed.
Received: 14 August 2017 / Revised: 13 December 2017 / Accepted: 15 December 2017 / Published: 21 December 2017
(This article belongs to the Special Issue Pathogenesis and Treatment of Neurodegenerative Diseases)
View Full-Text   |   Download PDF [2668 KB, uploaded 21 December 2017]   |  


Axonal damage is widely accepted as a major cause of permanent functional disability in Multiple Sclerosis (MS). In relapsing-remitting MS, there is a possibility of remyelination by myelin producing cells and restoration of neurological function. The purpose of this study was to delineate the pathophysiological mechanisms underpinning axonal injury through hitherto unknown factors present in cerebrospinal fluid (CSF) that may regulate axonal damage, remyelinate the axon and make functional recovery possible. We employed primary cultures of rat unmyelinated cerebellar granule neurons and treated them with CSF obtained from MS and Neuromyelitis optica (NMO) patients. We performed microarray gene expression profiling to study changes in gene expression in treated neurons as compared to controls. Additionally, we determined the influence of gene-gene interaction upon the whole metabolic network in our experimental conditions using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) program. Our findings revealed the downregulated expression of genes involved in glucose metabolism in MS-derived CSF-treated neurons and upregulated expression of genes in NMO-derived CSF-treated neurons. We conclude that factors in the CSF of these patients caused a perturbation in metabolic gene(s) expression and suggest that MS appears to be linked with metabolic deformity. View Full-Text
Keywords: multiple sclerosis; glucose metabolism; neuromyelitis optica; cerebrospinal fluid; gene expression multiple sclerosis; glucose metabolism; neuromyelitis optica; cerebrospinal fluid; gene expression

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mathur, D.; María-Lafuente, E.; Ureña-Peralta, J.R.; Sorribes, L.; Hernández, A.; Casanova, B.; López-Rodas, G.; Coret-Ferrer, F.; Burgal-Marti, M. Disturbed Glucose Metabolism in Rat Neurons Exposed to Cerebrospinal Fluid Obtained from Multiple Sclerosis Subjects. Brain Sci. 2018, 8, 1.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top