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Brain Sci. 2018, 8(1), 19;

Deep Brain Stimulation—Possible Treatment Strategy for Pathologically Altered Body Weight?

Department for Psychosomatic Medicine, Charité Center for Internal Medicine and Dermatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12200 Berlin, Germany
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany
Author to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 15 January 2018 / Accepted: 16 January 2018 / Published: 22 January 2018
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The treatment of obesity and eating disorders such as binge-eating disorder or anorexia nervosa is challenging. Besides lifestyle changes and pharmacological options, bariatric surgery represents a well-established and effective-albeit invasive-treatment of obesity, whereas for binge-eating disorder and anorexia nervosa mostly psychotherapy options exist. Deep brain stimulation (DBS), a method that influences the neuronal network, is by now known for its safe and effective applicability in patients with Parkinson’s disease. However, the use does not seem to be restricted to these patients. Recent preclinical and first clinical evidence points towards the use of DBS in patients with obesity and eating disorders as well. Depending on the targeted area in the brain, DBS can either inhibit food intake and body weight or stimulate energy intake and subsequently body weight. The current review focuses on preclinical and clinical evidence of DBS to modulate food intake and body weight and highlight the different brain areas targeted, stimulation protocols applied and downstream signaling modulated. Lastly, this review will also critically discuss potential safety issues and gaps in knowledge to promote further studies. View Full-Text
Keywords: anorexia nervosa; binge-eating disorder; depression, obesity; Parkinson’s disease anorexia nervosa; binge-eating disorder; depression, obesity; Parkinson’s disease

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Prinz, P.; Stengel, A. Deep Brain Stimulation—Possible Treatment Strategy for Pathologically Altered Body Weight? Brain Sci. 2018, 8, 19.

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