DBS in Treatment of Post-Traumatic Stress Disorder
by
Angelo Lavano 1,*, Giusy Guzzi 1, Attilio Della Torre 1, Serena Marianna Lavano 2, Raffaele Tiriolo 1 and Giorgio Volpentesta 1
Angelo Lavano 1,*, Giusy Guzzi 1, Attilio Della Torre 1, Serena Marianna Lavano 2, Raffaele Tiriolo 1 and Giorgio Volpentesta 1
1
Unit of Functional and Stereotactic Neurosurgery/Operative Unit of Neurosurgery, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy
2
Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(1), 18; https://doi.org/10.3390/brainsci8010018
Received: 6 December 2017 / Revised: 16 January 2018 / Accepted: 17 January 2018 / Published: 20 January 2018
(This article belongs to the Special Issue Update on Deep Brain Stimulation: Technical Nuances and New Indications)
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested and deep brain stimulation (DBS) is currently under investigation for patients affected by PTSD. We review the neurocircuitry and up-to-date clinical concepts which are behind the use of DBS in posttraumatic stress disorder (PTSD). The role of DBS in treatment-refractory PTSD patients has been investigated relying on both preclinical and clinical studies. DBS for PTSD is in its preliminary phases and likely to provide hope for patients with medical refractory PTSD following the results of randomized controlled studies.
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Keywords:
posttraumatic stress disorder; deep brain stimulation; fear extinction; amygdala; prefrontal cortex
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Lavano, A.; Guzzi, G.; Della Torre, A.; Lavano, S.M.; Tiriolo, R.; Volpentesta, G. DBS in Treatment of Post-Traumatic Stress Disorder. Brain Sci. 2018, 8, 18.
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