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Pathogens, Volume 12, Issue 10

2023 October - 87 articles

Cover Story: Malaria parasites in the Plasmodium genus are successful pathogens that replicate within vertebrate erythrocytes to escape host immunity and access hemoglobin as an amino acid source. Because intracellular growth limits access to essential nutrients in host plasma, these parasites insert an unusual nutrient and ion channel into their host’s erythrocyte membrane. This plasmodial surface anion channel (PSAC) and its parasite-derived subunits (CLAG3, RhopH2, and RhopH3) are conserved in all examined Plasmodium spp. Remarkably, while PSAC allows the uptake of diverse nutrients, anions, organic cations and some toxins, it must exclude the small Na+ ion to preserve host cell osmotic stability. We review the most unusual properties of this unusual microbial ion channel, which is an important target for antimalarial therapy development. View this paper
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Articles (87)

  • Article
  • Open Access
1 Citations
2,133 Views
20 Pages

Overoxidation and Oligomerization of Trypanosoma cruzi Cytosolic and Mitochondrial Peroxiredoxins

  • María Dolores Piñeyro,
  • María Laura Chiribao,
  • Diego G. Arias,
  • Carlos Robello and
  • Adriana Parodi-Talice

23 October 2023

Peroxiredoxins (Prxs) have been shown to be important enzymes for trypanosomatids, counteracting oxidative stress and promoting cell infection and intracellular survival. In this work, we investigate the in vitro sensitivity to overoxidation and the...

  • Brief Report
  • Open Access
2 Citations
1,852 Views
6 Pages

Absence of Coronavirus RNA in Faecal Samples from Wild Primates in Gabon, Central Africa

  • Illich Manfred Mombo,
  • Océane Rieu,
  • Matthieu Fritz,
  • Larson Boundenga,
  • Telstar Ndong Mebaley,
  • Clark Mbou-Boutambe,
  • Léadisaelle Hosanna Lenguiya,
  • Gael Darren Maganga,
  • Virginie Rougeron and
  • Eric M. Leroy
  • + 2 authors

23 October 2023

Coronaviruses (CoVs, Coronaviridae) are a diverse group of viruses that infect mammals, birds, and fish. Seven CoVs infect humans, among which Severe Acute Respiratory Syndrome CoVs-1 and -2 and Middle East respiratory syndrome CoVs have shown how th...

  • Case Report
  • Open Access
2 Citations
2,287 Views
8 Pages

Septic Obturation of a Knee Endoprosthesis Caused by Aspergillus clavatus

  • Robert Kuthan,
  • Gabriel Lawrence Zaremba-Wróblewski,
  • Flynn Ott and
  • Dorsa Soltaninia

23 October 2023

Aspergillus clavatus is a rare opportunistic fungal pathogen that can be isolated from various environmental sources, including soil and animal feces. Although infrequent, infections caused by A. clavatus can be severe in immunocompromised patients....

  • Review
  • Open Access
3 Citations
3,259 Views
18 Pages

The Bacterial Oral Microbiome in Children with Congenital Heart Disease: An Extensive Review

  • Maria Hofmann,
  • Nelly Schulz-Weidner,
  • Norbert Krämer and
  • Torsten Hain

21 October 2023

Children with congenital heart disease have poorer oral health compared with healthy children. Oral diseases, such as dental caries and gingivitis, are associated with the oral microbiome. The objective of this review was to find evidence of differen...

  • Article
  • Open Access
4 Citations
3,490 Views
13 Pages

Pooled Pharyngeal, Rectal, and Urine Specimens for the Point-of-Care Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by Lay Providers in Key Population-Led Health Services in Thailand

  • Narukjaporn Thammajaruk,
  • Reshmie A. Ramautarsing,
  • Akarin Hiransuthikul,
  • Sujittra Suriwong,
  • Waranya Tasomboon,
  • Prasopsuk Thapwong,
  • Atachai Phunkron,
  • Somporn Saiwaew,
  • Theeranat Sangpasert and
  • Nittaya Phanuphak
  • + 4 authors

21 October 2023

Routine testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in people with heightened risk is lacking in Thailand. This study aimed to assess the performance of the Cepheid Xpert CT/NG assay, conducted by key population (KP) lay pro...

  • Systematic Review
  • Open Access
4 Citations
2,879 Views
17 Pages

Meta-Analysis of the Prevalence of Porcine Zoonotic Bacterial Pathogens in India: A 13-Year (2010–2023) Study

  • Swaraj Rajkhowa,
  • Joyshikh Sonowal,
  • Udipta Borthakur,
  • Seema Rani Pegu,
  • Rajib Deb,
  • Pranab Jyoti Das,
  • Gyanendra Singh Sengar and
  • Vivek Kumar Gupta

21 October 2023

The presence of bacterial pathogens such as Brucella spp., Clostridium spp., E. coli, Listeria monocytogenes, Salmonella spp., Staphylococcus spp., and Streptococcus suis not only hampers pig production but also carries significant zoonotic implicati...

  • Review
  • Open Access
53 Citations
13,018 Views
24 Pages

Salmonella Infection in Pigs: Disease, Prevalence, and a Link between Swine and Human Health

  • Laura Soliani,
  • Gianluca Rugna,
  • Alice Prosperi,
  • Chiara Chiapponi and
  • Andrea Luppi

21 October 2023

Salmonella is one of the most spread foodborne pathogens worldwide, and Salmonella infections in humans still represent a global health burden. The main source of Salmonella infections in humans is represented by contaminated animal-derived foodstuff...

  • Review
  • Open Access
4 Citations
4,679 Views
20 Pages

Pneumocystis jirovecii Pneumonia after Heart Transplantation: Two Case Reports and a Review of the Literature

  • Carlo Burzio,
  • Eleonora Balzani,
  • Silvia Corcione,
  • Giorgia Montrucchio,
  • Anna Chiara Trompeo and
  • Luca Brazzi

21 October 2023

Post-transplant Pneumocystis jirovecii pneumonia (PcP) is an uncommon but increasingly reported disease among solid organ transplantation (SOT) recipients, associated with significant morbidity and mortality. Although the introduction of PcP prophyla...

  • Communication
  • Open Access
6 Citations
2,385 Views
10 Pages

Interleukin-6 and Its Soluble Receptor Complex in Intensive Care Unit COVID-19 Patients: An Analysis of Second Wave Patients

  • Gaetano Di Spigna,
  • Daniela Spalletti Cernia,
  • Bianca Covelli,
  • Maria Vargas,
  • Valentina Rubino,
  • Carmine Iacovazzo,
  • Filomena Napolitano and
  • Loredana Postiglione

20 October 2023

In December 2019, a SARS-CoV-2 virus, coined Coronavirus Disease 2019 (COVID-19), discovered in Wuhan, China, affected the global population, causing more than a million and a half deaths. Since then, many studies have shown that the hyperinflammator...

  • Editorial
  • Open Access
1 Citations
2,274 Views
3 Pages

Therapeutic Strategies against Leishmania and Trypanosoma

  • André L. S. Santos,
  • Igor A. Rodrigues,
  • Claudia M. d’Avila-Levy,
  • Cátia L. Sodré,
  • Koert Ritmeijer and
  • Marta H. Branquinha

19 October 2023

Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiolog...

  • Article
  • Open Access
1 Citations
1,825 Views
10 Pages

19 October 2023

Malaria stands as one of the most pervasive human infectious diseases globally and represents a prominent cause of mortality. Immunity against clinical malaria disease is achieved through multiple infection and treatment cycles, culminating in a subs...

  • Article
  • Open Access
3 Citations
3,146 Views
12 Pages

19 October 2023

In the landscape of healthcare disparities and the marginalized status of men who have sex with men (MSM) in Malaysia, understanding the dynamics surrounding HPV vaccination is of paramount importance. The purpose of this study is to examine the know...

  • Review
  • Open Access
13 Citations
4,709 Views
25 Pages

Plants and Their Derivatives as Promising Therapeutics for Sustainable Control of Honeybee (Apis mellifera) Pathogens

  • Roberto Bava,
  • Fabio Castagna,
  • Stefano Ruga,
  • Saverio Nucera,
  • Rosamaria Caminiti,
  • Maria Serra,
  • Rosa Maria Bulotta,
  • Carmine Lupia,
  • Mariangela Marrelli and
  • Ernesto Palma
  • + 3 authors

19 October 2023

The most important pollinator for agricultural crops is the Western honeybee (Apis mellifera). During the winter and summer seasons, diseases and stresses of various kinds endanger honeybee numbers and production, resulting in expenses for beekeepers...

  • Review
  • Open Access
108 Citations
19,665 Views
37 Pages

Respiratory Syncytial Virus Vaccines: A Review of the Candidates and the Approved Vaccines

  • Xanthippi Topalidou,
  • Alexis M. Kalergis and
  • Georgios Papazisis

19 October 2023

Respiratory syncytial virus (RSV) is responsible for a significant proportion of global morbidity and mortality affecting young children and older adults. In the aftermath of formalin-inactivated RSV vaccine development, the effort to develop an immu...

  • Review
  • Open Access
98 Citations
15,032 Views
31 Pages

Perception of Ticks and Tick-Borne Diseases Worldwide

  • José de la Fuente,
  • Agustín Estrada-Peña,
  • Marta Rafael,
  • Consuelo Almazán,
  • Sergio Bermúdez,
  • Abdelbaset E. Abdelbaset,
  • Paul D. Kasaija,
  • Fredrick Kabi,
  • Foluke Adedayo Akande and
  • Ananta Dahal
  • + 11 authors

19 October 2023

In this comprehensive review study, we addressed the challenge posed by ticks and tick-borne diseases (TBDs) with growing incidence affecting human and animal health worldwide. Data and perspectives were collected from different countries and regions...

  • Article
  • Open Access
12 Citations
2,857 Views
11 Pages

New Research on the Bacillus anthracis Genetic Diversity in Siberia

  • Vitalii Timofeev,
  • Irina Bakhteeva,
  • Kseniya Khlopova,
  • Raisa Mironova,
  • Galina Titareva,
  • Yulia Goncharova,
  • Viktor Solomentsev,
  • Tatiana Kravchenko,
  • Ivan Dyatlov and
  • Gilles Vergnaud

18 October 2023

Anthrax is a particularly dangerous infection of humans and ungulates caused by the Gram-positive spore-forming bacterium Bacillus anthracis. The highly monomorphic and clonal species B. anthracis is commonly divided into three main lineages, A,...

  • Article
  • Open Access
8 Citations
3,519 Views
11 Pages

Acquired blaVIM and blaGES Carbapenemase-Encoding Genes in Pseudomonas aeruginosa: A Seven-Year Survey Highlighting an Increasing Epidemiological Threat

  • María Guadalupe Martínez-Zavaleta,
  • Diana Fernández-Rodríguez,
  • Melissa Hernández-Durán,
  • Claudia A. Colín-Castro,
  • María de Lourdes García-Hernández,
  • Noé Becerra-Lobato,
  • Rafael Franco-Cendejas and
  • Luis Esaú López-Jácome

18 October 2023

(1) Background: Pseudomonas aeruginosa is a Gram-negative bacterium with several intrinsic and acquired antimicrobial resistance mechanisms. The spread of carbapenemase-encoding genes, an acquired mechanism, enables carbapenem resistance in clinical...

  • Article
  • Open Access
4 Citations
2,117 Views
12 Pages

18 October 2023

The expression of the Fasciola hepatica carboxylesterase type B (CestB) gene is known to be induced upon exposure to the anthelmintic triclabendazole (TCBZ), leading to a substantial rise in enzyme-specific activity. Furthermore, the nucleotide seque...

  • Article
  • Open Access
3 Citations
2,524 Views
15 Pages

Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort

  • Ying Chen,
  • Caiqin Hu,
  • Zheng Wang,
  • Junwei Su,
  • Shuo Wang,
  • Bin Li,
  • Xiang Liu,
  • Zhenzhen Yuan,
  • Dan Li and
  • Yiming Shao
  • + 2 authors

18 October 2023

Vaccination has proven to be highly effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the long-term immunogenicity and the functional preserved immune responses of vaccines are needed to inform evolving evidence-base...

  • Editorial
  • Open Access
1,783 Views
3 Pages

A Brief Focus on SARS-CoV-2 Genomic Evolution and Vaccines

  • Annamaria Pratelli and
  • Canio Buonavoglia

18 October 2023

Severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) emerged in a live animal market in the Hubei Province of Wuhan in China in late 2019 and was declared a pandemic by the World Health Organization (WHO) on 11 March 2020 [...]

  • Review
  • Open Access
13 Citations
7,774 Views
20 Pages

Evolution and Current Status of Influenza A Virus in Chile: A Review

  • Marcos Godoy,
  • Marco Montes de Oca,
  • Diego Caro,
  • Juan Pablo Pontigo,
  • Molly Kibenge and
  • Frederick Kibenge

17 October 2023

The influenza A virus (IAV) poses a significant global threat to public health and food security. Particularly concerning is the avian influenza virus (AIV) subtype H5N1, which has spread from Europe to North and Central/South America. This review pr...

  • Review
  • Open Access
2 Citations
4,503 Views
16 Pages

Outlook on RNAi-Based Strategies for Controlling Culicoides Biting Midges

  • Cameron J. Osborne,
  • Lee W. Cohnstaedt and
  • Kristopher S. Silver

17 October 2023

Culicoides are small biting midges with the capacity to transmit important livestock pathogens around much of the world, and their impacts on animal welfare are likely to expand. Hemorrhagic diseases resulting from Culicoides-vectored viruses, for ex...

  • Article
  • Open Access
4 Citations
2,973 Views
9 Pages

Glanders Diagnosis in an Asymptomatic Mare from Brazil: Insights from Serology, Microbiological Culture, Mass Spectrometry, and Genome Sequencing

  • Paula Adas Pereira Suniga,
  • Cynthia Mantovani,
  • Maria Goretti dos Santos,
  • Andréa Alves do Egito,
  • Newton Valério Verbisck,
  • Lenita Ramires dos Santos,
  • Alberto Martín Rivera Dávila,
  • Cristina Kraemer Zimpel,
  • Maria Carolina Sisco Zerpa and
  • Flábio Ribeiro de Araújo
  • + 3 authors

17 October 2023

This manuscript elucidates the occurrence of glanders in an asymptomatic mare from Brazil presenting positive Burkholderia mallei antibody titers. The diagnosis was established through a multi-pronged approach encompassing microbiological culture, ma...

  • Article
  • Open Access
5 Citations
2,549 Views
11 Pages

Molecular Characterisation of M. kansasii Isolates by Whole-Genome Sequencing

  • Priya Rajendran,
  • Chandrasekaran Padmapriyadarsini,
  • Naveenkumar Nagarajan,
  • Roja Samyuktha,
  • Vadivu Govindaraju,
  • Radhika Golla,
  • Shanmugavel Ashokkumar and
  • Sivakumar Shanmugam

17 October 2023

M. kansasii is the most common non-tuberculous mycobacteria, known to be causing pulmonary and extrapulmonary diseases in humans. Based on molecular methods, M. kansasii has been previously classified into seven different subtypes. Now, based on whol...

  • Communication
  • Open Access
4 Citations
2,301 Views
10 Pages

Screening for Hepatitis C Virus Reinfection Using a Behaviour-Based Risk Score among Men Who Have Sex with Men with HIV: Results from a Case–Control Diagnostic Validation Study

  • Kris Hage,
  • Marita van de Kerkhof,
  • Anders Boyd,
  • Joanne M. Carson,
  • Astrid M. Newsum,
  • Amy Matser,
  • Marc van der Valk,
  • Kees Brinkman,
  • Joop E. Arends and
  • Maria Prins
  • + 6 authors

16 October 2023

We assessed the predictive capacity of the HCV-MOSAIC risk score, originally developed for primary early HCV infection, as a screening tool for HCV reinfection in 103 men who have sex with men (MSM) with HIV using data from the MOSAIC cohort, includi...

  • Article
  • Open Access
9 Citations
3,646 Views
12 Pages

16 October 2023

In Japan, nationwide epidemiological surveys on carbapenem-resistant Enterobacterales (CREs), including comprehensive information, are scarce, with most data available only through public reports. This study analyzed data on the Enterobacterales fami...

  • Article
  • Open Access
40 Citations
5,114 Views
18 Pages

The Green Synthesis of Silver Nanoparticles from Avena fatua Extract: Antifungal Activity against Fusarium oxysporum f.sp. lycopersici

  • Ahmad Kaleem Qureshi,
  • Umar Farooq,
  • Qaiser Shakeel,
  • Sajjad Ali,
  • Sarfraz Ashiq,
  • Sohail Shahzad,
  • Muhammad Tariq,
  • Mahmoud F. Seleiman,
  • Aftab Jamal and
  • Barbara Manachini
  • + 1 author

16 October 2023

Using plant extracts as eco-friendly reducing and stabilizing agents for the synthesis of nanoparticles has gained significant attention in recent years. The current study explores the green synthesis of silver nanoparticles (AgNPs) using the Avena f...

  • Article
  • Open Access
9 Citations
6,978 Views
12 Pages

Oregano Essential Oil versus Conventional Disinfectants against Salmonella Typhimurium and Escherichia coli O157:H7 Biofilms and Damage to Stainless-Steel Surfaces

  • Jesus M. Luna-Solorza,
  • J. Fernando Ayala-Zavala,
  • M. Reynaldo Cruz-Valenzuela,
  • Gustavo A. González-Aguilar,
  • Ariadna T. Bernal-Mercado,
  • M. Melissa Gutierrez-Pacheco and
  • Brenda A. Silva-Espinoza

15 October 2023

This study compared the effect of oregano essential oil versus sodium hypochlorite, hydrogen peroxide, and benzalkonium chloride against the viability of adhered Salmonella Typhimurium and Escherichia coli O157:H7 on 304 stainless steel. Oregano esse...

  • Article
  • Open Access
4 Citations
2,279 Views
9 Pages

14 October 2023

Clostridioides difficile is a predominant nosocomial pathogen within the healthcare setting able to produce biofilms. Sub-minimum inhibitory concentrations (sub-MICs) of antibiotics trigger mechanisms affecting bacterial virulence, including increase...

  • Communication
  • Open Access
1 Citations
2,248 Views
10 Pages

First Molecular Detection and Genotype Identification of Toxoplasma gondii in Chickens from Farmers’ Markets in Fujian Province, Southeastern China

  • Meng-Jie Chu,
  • Li-Yuan Huang,
  • Wen-Yuan Miao,
  • Ya-Fei Song,
  • Ying-Sheng Lin,
  • Si-Ang Li and
  • Dong-Hui Zhou

13 October 2023

Toxoplasma gondii is an opportunistic pathogenic protozoan that can infect all nucleated cells in almost all warm-blooded animals, including humans. T. gondii infection has been reported in many food animals worldwide. However, the prevalence and gen...

  • Article
  • Open Access
5 Citations
2,880 Views
17 Pages

Novel Baicalein-Derived Inhibitors of Plasmodium falciparum

  • Chandra Sekhar Gudla,
  • Vignesh Selvam,
  • Siva Shanmugam Selvaraj,
  • Renu Tripathi,
  • Prince Joshi,
  • Salique Hassan Shaham,
  • Mayas Singh,
  • Radha Krishan Shandil,
  • Saman Habib and
  • Shridhar Narayanan

13 October 2023

Malaria, a life-threatening mosquito-borne disease caused by Plasmodium parasites, continues to pose a significant global health burden. Despite notable progress in combating the disease in recent years, malaria remains prevalent in many regions, par...

  • Article
  • Open Access
1 Citations
2,596 Views
18 Pages

Natural Killer Repertoire Restoration in TB/HIV Co-Infected Individuals Experienced an Immune Reconstitution Syndrome (CAMELIA Trial, ANRS 12153)

  • Polidy Pean,
  • Yoann Madec,
  • Eric Nerrienet,
  • Laurence Borand,
  • Didier Laureillard,
  • Marcelo Fernandez,
  • Olivier Marcy and
  • Daniel Scott-Algara

13 October 2023

IRIS is a common complication in HIV-infected patients treated for tuberculosis (TB) and cART. Our aim was to evaluate NK cell reconstitution in HIV-infected patients with TB-IRIS compared to those without IRIS. 147 HIV-infected patients with TB from...

  • Article
  • Open Access
15 Citations
4,345 Views
11 Pages

Factors Associated with Toxoplasma gondii Seroprevalence in Pregnant Women: A Cross-Sectional Study in Belgrade, Serbia

  • Ljiljana Marković-Denić,
  • Milena Stopić,
  • Branko Bobić,
  • Vladimir Nikolić,
  • Iva Djilas,
  • Snežana Jovanović Srzentić and
  • Tijana Štajner

13 October 2023

Toxoplasmosis, caused by the cosmopolitan protozoan Toxoplasma gondii, has particular implications during pregnancy due to the possible transmission of infection to the fetus. Very few studies have assessed seroprevalence and the risk factors for tox...

  • Article
  • Open Access
6 Citations
4,008 Views
15 Pages

Characterization of mRNA Signature in Milk Small Extracellular Vesicles from Cattle Infected with Bovine Leukemia Virus

  • Md. Matiur Rahman,
  • Hinata Ishikawa,
  • Marika Yamauchi,
  • Shigeo Takashima,
  • Yuji O. Kamatari,
  • Kaori Shimizu,
  • Ayaka Okada and
  • Yasuo Inoshima

13 October 2023

This study aimed to characterize the mRNA signature of milk small extracellular vesicles (sEVs) from BLV-infected cattle. A total of 23 mRNAs, which showed greater abundance in milk sEVs from BLV-infected cattle compared to those from BLV-uninfected...

  • Article
  • Open Access
1 Citations
2,312 Views
8 Pages

13 October 2023

Reservoir host associations have been observed among and within Borrelia genospecies, and host complement-mediated killing is a major determinant in these interactions. In North America, only a subset of Borrelia burgdorferi lineages cause the majori...

  • Brief Report
  • Open Access
2 Citations
1,719 Views
10 Pages

13 October 2023

Yeasts associated with lepidopteran pests have been shown to play a role in their survival, development, and oviposition preference. It has been demonstrated that combining these yeasts with existing biological control agents can enhance their effica...

  • Article
  • Open Access
1 Citations
1,338 Views
9 Pages

12 October 2023

As demands for fresh water become more competitive between the processing plant and other consumers of water such as municipalities, interest has grown in recycling or reusing water for food processing. However, recycling the processing water from a...

  • Article
  • Open Access
3 Citations
1,790 Views
15 Pages

Serological Biomarkers at Hospital Admission and Hospitalization Treatments Are Not Related to Sensitization-Associated Symptoms in Patients with Post-COVID Pain

  • César Fernández-de-las-Peñas,
  • Carlos Guijarro,
  • Juan Torres-Macho,
  • Oscar J. Pellicer-Valero,
  • Ana Franco-Moreno,
  • Jo Nijs and
  • María Velasco-Arribas

12 October 2023

Current evidence suggests that a group of patients who had survived coronavirus disease, 2019 (COVID-19) and developed post-COVID pain can exhibit altered nociceptive processing. The role of serological biomarkers and hospitalization treatments in po...

  • Article
  • Open Access
3,701 Views
13 Pages

Human Papillomavirus Genotype Richness and the Biodiversity of Squamous and Glandular Cervical Dysplasias: A Cross-Sectional Study

  • Elisa Gozzini,
  • Davide Radice,
  • Fabio Bottari,
  • Sara Boveri,
  • Maria Elena Guerrieri,
  • Eleonora Petra Preti,
  • Noemi Spolti,
  • Mariacristina Ghioni,
  • Federico Ferrari and
  • Anna Daniela Iacobone

11 October 2023

The impact of multiple infections on the risk of cervical lesions is a subject of ongoing debate. This study aims to explore whether the richness of HPV genotype infections and the biodiversity of squamous and glandular cervical dysplasias could infl...

  • Review
  • Open Access
17 Citations
5,593 Views
16 Pages

The Use of Innovative Diagnostics to Inform Sustainable Control of Equine Helminth Infections

  • Jacqueline B. Matthews,
  • Natalia Peczak and
  • Kirsty L. Lightbody

11 October 2023

Helminths are commonly found in grazing equids, with cyathostomin nematodes and the cestode Anoplocephala perfoliata being the most prevalent. Most horses harbour low burdens of these parasites and do not develop signs of infection; however, in a sma...

  • Article
  • Open Access
6 Citations
2,333 Views
14 Pages

Functional Characterization of Eight Zinc Finger Motif-Containing Proteins in Toxoplasma gondii Type I RH Strain Using the CRISPR-Cas9 System

  • Jin Gao,
  • Xiao-Jing Wu,
  • Xiao-Nan Zheng,
  • Ting-Ting Li,
  • Yong-Jie Kou,
  • Xin-Cheng Wang,
  • Meng Wang and
  • Xing-Quan Zhu

11 October 2023

The Zinc finger protein (ZFP) family is widely distributed in eukaryotes and interacts with DNA, RNA, and various proteins to participate in many molecular processes. In the present study, the biological functions of eight ZFP genes in the lytic cycl...

  • Article
  • Open Access
5 Citations
2,462 Views
13 Pages

Toll-like Receptor Ligands Enhance Vaccine Efficacy against a Virulent Newcastle Disease Virus Challenge in Chickens

  • Chang-Won Lee,
  • Abhijeet Bakre,
  • Timothy L. Olivier,
  • Sonsiray Alvarez-Narvaez,
  • Telvin L. Harrell and
  • Steven J. Conrad

11 October 2023

To enhance the efficacy of the current Newcastle disease vaccine, we have selected potential adjuvants that target well-characterized pattern recognition receptors: the toll-like receptors (TLRs). Imiquimod is a small-molecule activator of TLR7, whic...

  • Article
  • Open Access
3 Citations
2,454 Views
10 Pages

Development of an Ex Vivo Assay for Identification of Infectious Hepatitis E Virus in Different Kinds of Food Samples

  • Renate W. Hakze-van der Honing,
  • Sophie van Oort,
  • René A. M. Dirks and
  • Wim H. M. van der Poel

11 October 2023

Hepatitis E virus (HEV) is a positive-sense single-stranded RNA virus and a major cause of acute viral hepatitis. HEV is responsible for 20 million infections worldwide in humans every year. HEV-3 and HEV-4 are zoonotic and are responsible for most o...

  • Editorial
  • Open Access
2 Citations
2,560 Views
4 Pages

10 October 2023

Ticks (Acari: Ixodida) are hematophagous ectoparasitic arachnids that feed on the blood of vertebrate hosts, posing significant concern due to their unrivaled capacity to transmit various pathogens, which surpasses those of all other known arthropod...

  • Communication
  • Open Access
1 Citations
2,357 Views
13 Pages

Identification of Potential Hazards Associated with South Korean Prawns and Monitoring Results Targeting Fishing Bait

  • Gyoungsik Kang,
  • Won-Sik Woo,
  • Kyung-Ho Kim,
  • Ha-Jeong Son,
  • Min-Young Sohn,
  • Hee Jeong Kong,
  • Young-Ok Kim,
  • Dong-Gyun Kim,
  • Eun Mi Kim and
  • Chan-Il Park
  • + 1 author

10 October 2023

This study detected two potential pathogens, Vibro parahaemolyticus, which causes acute hepatopancreatic necrosis disease (AHPND), and white spot syndrome virus (WSSV), in fishing bait in South Korea. However, their infectious nature was not confirme...

  • Article
  • Open Access
2 Citations
2,301 Views
17 Pages

In Vivo Efficacy of Curcumin and Curcumin Nanoparticle in Trypanosoma congolense, Broden 1904 (Kinetoplastea: Trypanosomatidae)-Infected Mice

  • Nthatisi Innocentia Molefe-Nyembe,
  • Oluyomi Stephen Adeyemi,
  • Daisuke Kondoh,
  • Kentaro Kato,
  • Noboru Inoue and
  • Keisuke Suganuma

9 October 2023

Curcumin (CUR) is known for its wide folkloric effects on various infections; however, its solubility status has remained a hindrance to its bioavailability in the host. This study evaluated the comparative effects of CUR and CUR-nanoparticle in vitr...

  • Article
  • Open Access
7 Citations
3,143 Views
12 Pages

Distribution of Opportunistic Pathogens in People Living with HIV at a University Hospital in Istanbul over a One-Year Treatment Period and Its Association with CD4 T Cell Counts

  • Hayriye Kirkoyun Uysal,
  • Muammer Osman Koksal,
  • Kutay Sarsar,
  • Pinar Soguksu,
  • Gonca Erkose Genc,
  • Gizem Yapar,
  • Evrim Ozdemir,
  • Mustafa Onel,
  • Sevim Mese and
  • Ali Agacfidan
  • + 4 authors

9 October 2023

Among sexually transmitted diseases, HIV causes very serious clinical manifestations that can lead to death. As a result, millions of people have to live with this problem that threatens their health. The virus attacks the immune system of the host,...

  • Article
  • Open Access
3 Citations
2,872 Views
14 Pages

Immunohistochemical Characterization of M1, M2, and M4 Macrophages in Leprosy Skin Lesions

  • Tatiane Costa Quaresma,
  • Lívia de Aguiar Valentim,
  • Jorge Rodrigues de Sousa,
  • Tinara Leila de Souza Aarão,
  • Hellen Thais Fuzii,
  • Maria Irma Seixas Duarte,
  • Juarez de Souza and
  • Juarez Antônio Simões Quaresma

9 October 2023

Mycobacterium leprae is the etiological agent of leprosy. Macrophages (Mφs) are key players involved in the pathogenesis of leprosy. In this study, immunohistochemical analysis was performed to examine the phenotype of Mφ subpopulations, name...

  • Article
  • Open Access
5 Citations
1,999 Views
11 Pages

8 October 2023

Ovine footrot and contagious ovine digital dermatitis (CODD) cause lameness in sheep, affecting welfare and economics. Previous Swedish studies focused on individual slaughter lambs, leaving flock-wide prevalence less explored. This study examined th...

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Pathogens - ISSN 2076-0817