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Journal of Personalized Medicine, Volume 15, Issue 11

November 2025 - 62 articles

Cover Story: Digital twins are poised to reshape personalized medicine by fusing genomics, imaging, sensor streams, and EHRs into virtual patient models that enable real-time, patient-specific simulation and decision support. This review bridges promise and practice: we map clinical use cases across cardiology, oncology, neurology, and pharmacogenomics, identify the translational gaps limiting routine adoption, and propose a pragmatic roadmap dynamic validation, clinician co-development, interoperable data pipelines, equity by design, and regulatory/ethical guardrails. We argue that digital twins should function as cognitive tools embedded in clinical workflows, accelerating safe, evidence-based precision care. View this paper
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Articles (62)

  • Systematic Review
  • Open Access
892 Views
34 Pages

Artificial Intelligence in Gastrointestinal Surgery: A Systematic Review of Its Role in Laparoscopic and Robotic Surgery

  • Ludovica Gorini,
  • Roberto de la Plaza Llamas,
  • Daniel Alejandro Díaz Candelas,
  • Rodrigo Arellano González,
  • Wenzhong Sun,
  • Jaime García Friginal,
  • María Fra López and
  • Ignacio Antonio Gemio del Rey

19 November 2025

Background: Artificial intelligence (AI) is transforming surgical practice by enhancing training, intraoperative guidance, decision-making, and postoperative assessment. However, its specific role in laparoscopic and robotic general surgery remains t...

  • Article
  • Open Access
457 Views
12 Pages

Mood and Metabolism: A Bayesian Network Analysis of Depressive Symptoms in Major Depressive Disorder and Metabolic Syndrome

  • Tommaso B. Jannini,
  • Daniele Mollaioli,
  • Susanna Longo,
  • Cherubino Di Lorenzo,
  • Cinzia Niolu,
  • Massimo Federici and
  • Giorgio Di Lorenzo

19 November 2025

Background/Objectives: Major depressive disorder (MDD) and metabolic syndrome (MetS) are highly prevalent, bidirectionally linked conditions. Individuals with MetS are at increased risk of developing depression, while depression predisposes to metabo...

  • Article
  • Open Access
319 Views
12 Pages

19 November 2025

Purpose: We aimed to study the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) in the treatment of unresectable hepatocellular carcinoma (HCC) with extrahepatic spread (EHS). Materials and Methods: A total of 323 patients with unre...

  • Review
  • Open Access
484 Views
51 Pages

Personalized Immunotherapy for T Cell Lymphomas: From Immune Escape to Precision Therapeutics

  • Joshua M. L. Casan,
  • Xiao Jing Ong,
  • Carrie van der Weyden,
  • Costas K. Yannakou,
  • Joe Zhu,
  • Criselle D’Souza,
  • Paul Neeson and
  • H. Miles Prince

18 November 2025

Despite recent progress in lymphoma immunotherapy, outcomes for patients with peripheral T cell lymphomas (PTCLs) remain poor. The challenge of PTCLs reflects the profound biological heterogeneity and relative rarity of this disease group and its res...

  • Article
  • Open Access
426 Views
12 Pages

Nationwide Trends in Demographics, Comorbidities, and Mortality Among Elderly Patients with Heart Failure with Preserved Ejection Fraction Hospitalized with Cardiac Arrest

  • Adil Sarvar Mohammed,
  • Maya Asami Takagi,
  • Umera Yasmeen,
  • Aashna Gandhi,
  • Ayesha Firdous Shafiulla Khan,
  • Apurva Popat,
  • Rupak Desai,
  • Shrinivas Kambali,
  • Ahmad Khalil A. Koshak and
  • Sohaib Mandoorah

18 November 2025

Background: Heart failure with preserved ejection fraction (HFpEF) is a major cause of hospitalization and mortality in older adults. Sudden cardiac arrest (SCA) is a leading cause of death in this population, yet national trends in incidence, outcom...

  • Article
  • Open Access
337 Views
20 Pages

Enhanced Detection of αGal Using a Novel Monoclonal IgG1 Antibody: Comparative Evaluation with IgM Antibody [Clone M86]

  • Rosa Di Liddo,
  • Filippo Naso,
  • Alessandro Gandaglia,
  • Giulio Sturaro,
  • Michele Spina and
  • Robert J. Melder

17 November 2025

Introduction. Over the past two decades, the αGal (Galα1–3Galβ1–4GlcNAc–R) epitope, a carbohydrate found in many non-primate mammals, has gained significant relevance in medicine due to its association with an incre...

  • Article
  • Open Access
382 Views
10 Pages

Pregnancy and Childbirth in Neurodivergent Women: Shift Towards Personalized Maternity Care

  • Anna M. Avdeeva,
  • Mariia A. Parfenenko,
  • Elena V. Bryzgalina,
  • Kamilla T. Muminova and
  • Zulfiya S. Khodzhaeva

17 November 2025

Introduction: Neurodevelopmental disorders (NDs), including autism spectrum disorder and related conditions, are increasingly recognized among women of reproductive age, yet their unique needs during pregnancy and childbirth remain poorly studied. Co...

  • Review
  • Open Access
444 Views
13 Pages

Facial Clefts and the Trigeminal Nerve: A Narrative Review of the Literature and Clinical Considerations in the Era of Personalized Medicine

  • Natalia Lucangeli,
  • Matilde S. Cannistrà,
  • Domenico Scopelliti,
  • Pasquale Parisi,
  • Domenico Tripodi,
  • Patrick Barbet and
  • Claudio Cannistrà

15 November 2025

Background Facial clefts are rare congenital malformations, occurring in approximately 1 in 700 live births for cleft lip and palate and fewer than 1 in 100,000 for atypical Tessier clefts. They pose significant diagnostic and surgical challenges. Wh...

  • Article
  • Open Access
414 Views
15 Pages

Intravitreal Aflibercept for the Treatment of Diabetic Retinopathy Among Patients Who Completed PANORAMA: 1-Year Outcomes from the VOYAGE Extension Study

  • Avery W. Zhou,
  • Gail M. Teagle,
  • Liisa M. Baumann,
  • Jessica A. Cao,
  • Andres Emanuelli,
  • Allen Y. Hu,
  • Adam S. Berger,
  • James C. Major,
  • Seong Y. Lee and
  • Stephen M. Huddleston
  • + 17 authors

14 November 2025

Background/Objectives: Evaluate outcomes and treatment patterns with 2 mg intravitreal aflibercept injection among patients who completed the phase 3 PANORAMA trial and enrolled in the VOYAGE (ClinicalTrials.gov identifier, NCT04708145; 12 January 20...

  • Study Protocol
  • Open Access
258 Views
9 Pages

13 November 2025

Background/Objectives: Many patients with breast cancer are treated with chemotherapy, including taxanes. These regimens bear a significant risk of potentially burdensome peripheral neuropathy. A scoring system supported by a neuropathy tracker, whic...

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J. Pers. Med. - ISSN 2075-4426