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Journal of Personalized Medicine, Volume 11, Issue 4

April 2021 - 82 articles

Cover Story: What the optimal duration of post-operative adjuvant mitotane for adrenocortical carcinoma (ACC) is remains unclear. We addressed this issue in 154 patients with ACC followed at 14 expert centers after complete extirpation of the tumor, assessing recurrence-free survival (RFS) and RFS following mitotane discontinuation to account for immortal time bias. We found a wide variability in the duration of adjuvant mitotane treatment among different centers and among patients treated at the same center, reflecting heterogeneous practice. We did not find any survival advantage in patients treated for longer than 24 months. Therefore, the present findings do not support the concept that extending adjuvant mitotane treatment beyond two years is beneficial for patients with ACC at low to moderate risk of recurrence. View this paper
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Articles (82)

  • Article
  • Open Access
14 Citations
4,463 Views
10 Pages

20 April 2021

Background: Oral health-related conditions are among the common conditions seen in adults in India. The usage of inappropriate measurement tools that are unvalidated may result in deceptive and imprecise findings that might lead to substandard plans...

  • Article
  • Open Access
8 Citations
3,692 Views
8 Pages

Pharmacogenetic Polygenic Risk Score for Bronchodilator Response in Children and Adolescents with Asthma: Proof-of-Concept

  • Joanne E. Sordillo,
  • Sharon M. Lutz,
  • Michael J. McGeachie,
  • Jessica Lasky-Su,
  • Scott T. Weiss,
  • Juan C. Celedón and
  • Ann Chen Wu

20 April 2021

Genome-wide association studies (GWAS) of response to asthma medications have primarily focused on Caucasian populations, with findings that may not be generalizable to minority populations. We derived a polygenic risk score (PRS) for response to alb...

  • Review
  • Open Access
27 Citations
4,971 Views
12 Pages

The Role of Artificial Intelligence in Managing Multimorbidity and Cancer

  • Alfredo Cesario,
  • Marika D’Oria,
  • Riccardo Calvani,
  • Anna Picca,
  • Antonella Pietragalla,
  • Domenica Lorusso,
  • Gennaro Daniele,
  • Franziska Michaela Lohmeyer,
  • Luca Boldrini and
  • Vincenzo Valentini
  • + 3 authors

19 April 2021

Traditional healthcare paradigms rely on the disease-centered approach aiming at reducing human nature by discovering specific drivers and biomarkers that cause the advent and progression of diseases. This reductive approach is not always suitable to...

  • Review
  • Open Access
24 Citations
7,238 Views
28 Pages

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

  • Lynn M. Oswald,
  • Kelly E. Dunn,
  • David A. Seminowicz and
  • Carla L. Storr

19 April 2021

A robust body of research has shown that traumatic experiences occurring during critical developmental periods of childhood when neuronal plasticity is high increase risks for a spectrum of physical and mental health problems in adulthood, including...

  • Article
  • Open Access
18 Citations
3,974 Views
13 Pages

Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer

  • Chia-Jung Li,
  • Li-Te Lin,
  • Pei-Yi Chu,
  • An-Jen Chiang,
  • Hsiao-Wen Tsai,
  • Yi-Han Chiu,
  • Mei-Shu Huang,
  • Zhi-Hong Wen and
  • Kuan-Hao Tsui

19 April 2021

This paper investigates the expression of the CREB1 gene in ovarian cancer (OV) by deeply excavating the gene information in the multiple databases and the mechanism thereof. In short, we found that the expression of the CREB1 gene in ovarian cancer...

  • Study Protocol
  • Open Access
6 Citations
3,895 Views
10 Pages

Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial

  • Yuji Yamada,
  • Takuma Inagawa,
  • Yuma Yokoi,
  • Aya Shirama,
  • Kazuki Sueyoshi,
  • Ayumu Wada,
  • Naotsugu Hirabayashi,
  • Hideki Oi and
  • Tomiki Sumiyoshi

19 April 2021

Backgrounds: Social cognition is defined as the mental operations underlying social behavior. Patients with schizophrenia elicit impairments of social cognition, which is linked to poor real-world functional outcomes. In a previous study, transcrania...

  • Article
  • Open Access
7 Citations
3,713 Views
15 Pages

The Challenging Diagnosis of Pediatric Multisystem Inflammatory Syndrome Associated with Sars-Cov-2 Infection-Two Case Reports and Literature Review

  • Marcela Daniela Ionescu,
  • Roxana Taras,
  • Bianca Dombici,
  • Mihaela Balgradean,
  • Elena Camelia Berghea and
  • Alin Nicolescu

19 April 2021

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a novel coronavirus discovered in 2019 that caused the coronavirus disease 2019 (COVID19). During the last year, over 70 million people were infected and more than 1.5 million people died. Despit...

  • Article
  • Open Access
11 Citations
3,524 Views
11 Pages

Machine Learning in Prediction of IgA Nephropathy Outcome: A Comparative Approach

  • Andrzej Konieczny,
  • Jakub Stojanowski,
  • Magdalena Krajewska and
  • Mariusz Kusztal

17 April 2021

We are overwhelmed by a deluge of data and, although its interpretation is challenging, fortunately, information technology comes to the rescue. One of the tools is artificial intelligence, allowing the identification of relationships between variabl...

  • Article
  • Open Access
8 Citations
3,692 Views
12 Pages

Autonomic Dysfunction Contributes to Impairment of Cerebral Autoregulation in Patients with Epilepsy

  • Shu-Fang Chen,
  • Hsiu-Yung Pan,
  • Chi-Ren Huang,
  • Jyun-Bin Huang,
  • Teng-Yeow Tan,
  • Nai-Ching Chen,
  • Chung-Yao Hsu and
  • Yao-Chung Chuang

17 April 2021

Patients with epilepsy frequently experience autonomic dysfunction and impaired cerebral autoregulation. The present study investigates autonomic function and cerebral autoregulation in patients with epilepsy to determine whether these factors contri...

  • Article
  • Open Access
16 Citations
3,771 Views
15 Pages

Myristic Acid Serum Levels and Their Significance for Diagnosis of Systemic Inflammatory Response, Sepsis, and Bacteraemia

  • Roman Zazula,
  • Michal Moravec,
  • František Pehal,
  • Tomáš Nejtek,
  • Marek Protuš and
  • Martin Müller

16 April 2021

Myristic acid is identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Its significant decrease has been observed in patients with septic shock not responding to treatment....

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J. Pers. Med. - ISSN 2075-4426