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Diagnostics, Volume 15, Issue 3

February-1 2025 - 163 articles

Cover Story: In this study, ctDNA and [18F]FDG-PET/CT were investigated during the first cycle of anticancer therapy in patients with NSCLC to explore their potential for early response evaluation. Of the sixteen included patients, eight were non-responders. ctDNA mutations were detected in baseline blood samples in eight patients. Changes in ctDNA level, MTV4.0, and sumSULpeak at week 3 indicated response in 7 out of 8 patients, 13 out of 15 patients, and 9 out of 15 patients, respectively. At week 3, no false increases were seen with ctDNA and MTV4.0. These results suggest that early changes in ctDNA and [18F]FDG-PET/CT at 3 weeks of treatment could be used to early assess treatment response. Increased levels of ctDNA and MTV4.0 at week 3 were only observed in patients with treatment failure. View this paper
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Articles (163)

  • Review
  • Open Access
9 Citations
4,562 Views
34 Pages

Optimizing Cancer Treatment: Exploring the Role of AI in Radioimmunotherapy

  • Hossein Azadinejad,
  • Mohammad Farhadi Rad,
  • Ahmad Shariftabrizi,
  • Arman Rahmim and
  • Hamid Abdollahi

Radioimmunotherapy (RIT) is a novel cancer treatment that combines radiotherapy and immunotherapy to precisely target tumor antigens using monoclonal antibodies conjugated with radioactive isotopes. This approach offers personalized, systemic, and du...

  • Review
  • Open Access
9 Citations
6,303 Views
24 Pages

Harnessing Artificial Intelligence in Obesity Research and Management: A Comprehensive Review

  • Sarfuddin Azmi,
  • Faisal Kunnathodi,
  • Haifa F. Alotaibi,
  • Waleed Alhazzani,
  • Mohammad Mustafa,
  • Ishtiaque Ahmad,
  • Riyasdeen Anvarbatcha,
  • Miltiades D. Lytras and
  • Amr A. Arafat

Purpose: This review aims to explore the clinical and research applications of artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), in understanding, predicting, and managing obesity. It assesses the use of AI tool...

  • Article
  • Open Access
2 Citations
1,770 Views
21 Pages

Three-Dimensional Geometric Morphometric Characterization of Facial Sexual Dimorphism in Juveniles

  • Riccardo Solazzo,
  • Annalisa Cappella,
  • Daniele Gibelli,
  • Claudia Dolci,
  • Gianluca Tartaglia and
  • Chiarella Sforza

Background: The characterization of facial sexual dimorphic patterns in healthy populations serves as valuable normative data to tailor functionally effective surgical treatments and predict their aesthetic outcomes and to identify dysmorphic facial...

  • Systematic Review
  • Open Access
3 Citations
2,284 Views
13 Pages

A Systematic Review of Circulating miRNAs Validated by Multiple Independent Studies in Laryngeal Cancer

  • Andreea Banta,
  • Felix Bratosin,
  • Ioana Golu,
  • Ana-Olivia Toma and
  • Eugenia Maria Domuta

Background and Objectives: Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer with significant morbidity and mortality. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer diagnosis and p...

  • Article
  • Open Access
2 Citations
1,704 Views
9 Pages

Cardiac Morpho-Functional Changes, Inflammation and Fibrosis in Systemic Sclerosis—A Pilot Study of a Tertiary Center Cohort

  • Karolina Dorniak,
  • Zuzanna Gogulska,
  • Alessandro Viti,
  • Anna Glińska,
  • Dorota Kulawiak-Gałąska,
  • Jadwiga Fijałkowska,
  • Anna Wojteczek,
  • Dagmara Wojtowicz,
  • Katarzyna Sienkiewicz and
  • Marcin Hellmann
  • + 1 author

Background: Cardiac involvement (CI) in systemic sclerosis (SSc) is frequently subclinical and it can be identified in up to 80% of autopsied hearts. If present, symptoms are related to adverse prognosis, and CI represents one of the predominant caus...

  • Review
  • Open Access
5 Citations
7,244 Views
16 Pages

Role of Ultrasound in Evaluating Ligament Injuries Around the Ankle: A Narrative Review

  • Soichi Hattori,
  • Rachit Saggar,
  • Joseph Mullen,
  • Abdulganeey Olawin,
  • Eva Heidinger,
  • Warren Austin,
  • Akeem Williams,
  • Glenn Reeves and
  • MaCalus Vinson Hogan

Ultrasound has emerged as a valuable imaging modality for evaluating ligamentous injuries around the ankle joint, offering several advantages over traditional imaging techniques. It is more cost-effective and widely available than MRI, and it avoids...

  • Correction
  • Open Access
819 Views
3 Pages

In the original publication [...]

  • Article
  • Open Access
1 Citations
1,515 Views
20 Pages

Background and Objectives: Accurate screening of clinically significant tumor mutations is critical for precision medicine in oncology. This requires genotyping platforms with high accuracy and compatibility with varying DNA yields from challenging s...

  • Article
  • Open Access
1 Citations
2,920 Views
16 Pages

Validation of Ultrasound for Quantification of Knee Meniscal Tissue: A Cadaveric Study

  • Jacobo Rodríguez-Sanz,
  • Miguel Malo-Urriés,
  • Sergio Borrella-Andrés,
  • Isabel Albarova-Corral and
  • Carlos López-de-Celis

Background: While MRI is the gold standard for meniscal assessment, its cost and accessibility limitations have led to growing interest in ultrasound, though its validity for quantifying meniscal tissue remains unclear. To validate the use of ultraso...

  • Review
  • Open Access
2 Citations
2,321 Views
13 Pages

Thyroid-associated ophthalmopathy (TAO) is a vision-threatening autoimmune disease that involves the extraocular muscles (EOMs) and periorbital fat. Typical signs of TAO include eyelid recession, proptosis, diplopia, and decreased visual acuity. As a...

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Diagnostics - ISSN 2075-4418