Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296

Ong, Khaa Hoo; Hsieh, Yao-Yu; Sun, Ding-Ping; Huang, Steven Kuan-Hua; Tian, Yu-Feng; Chou, Chia-Lin; Shiue, Yow-Ling; Joseph, Keva; Chang, I-Wei

doi:10.3390/diagnostics15030391

Open AccessCorrection

Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296

by

Khaa Hoo Ong

^1,2,3,†,

Yao-Yu Hsieh

^4,5,†,

Ding-Ping Sun

¹,

Steven Kuan-Hua Huang

^6,7,

Yu-Feng Tian

⁸,

Chia-Lin Chou

^2,8,

Yow-Ling Shiue

^3,9

,

Keva Joseph

¹⁰ and

I-Wei Chang

^{11,12,13,14,*}

¹

Division of Gastroenterology & General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan

²

Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan

³

Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan

⁴

Division of Hematology and Oncology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei 235, Taiwan

⁵

Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

⁶

Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan

⁷

Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan

⁸

Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan

⁹

Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung 804, Taiwan

¹⁰

St. Jude Hospital, Vieux Fort LC12 201, Saint Lucia

¹¹

Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

¹²

Department of Clinical Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan

¹³

Department of Pathology, Taipei Medical University Hospital, Taipei 110, Taiwan

¹⁴

Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei 235, Taiwan

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^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Diagnostics 2025, 15(3), 391; https://doi.org/10.3390/diagnostics15030391

Submission received: 27 January 2025 / Accepted: 27 January 2025 / Published: 6 February 2025

(This article belongs to the Special Issue Advanced Pathology and Diagnostics in Gastroenterology and Liver Diseases)

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Versions Notes

In the original publication [1], there was a mistake in Figure 3B as published. The group with the poorer outcome in Figure 3B should have been labeled “CPS1 Low Exp”. The corrected Figure 3 appears below.

There was an error in the original publication. “Disease-free survival (DFS)” should be replaced with “disease-specific survival (DSS)”.

A correction has also been made to the Abstract:

CPS1 underexpression was not only negatively correlated to overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS) in univariate analysis but also an independent prognosticator to forecast poorer clinical outcome for all prognostic indices (OS, DSS, LRFS and MeFs) in patients with IHCC (all p ≤ 0.001).

A correction has also been made to the Discussion section, Paragraph 4:

Furthermore, CPS1 underexpression was not only negatively correlated to overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS) in univariate analysis but also an independent prognosticator to forecast poorer clinical outcome for all prognostic indices (OS, DSS, LRFS and MeFs) in patients with IHCC (all p ≤ 0.001).

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

Ong, K.H.; Hsieh, Y.-Y.; Sun, D.-P.; Huang, S.K.-H.; Tian, Y.-F.; Chou, C.-L.; Shiue, Y.-L.; Joseph, K.; Chang, I.-W. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296. [Google Scholar] [CrossRef] [PubMed]

Figure 3. Kaplan–Meier estimator demonstrated the significantly poorer clinical outcomes, including (A) overall survival (OS), (B) disease-specific survival (DSS), (C) local recurrence-free survival (LRFS) and (D) distant metastasis-free survival (MeFS) in relation to the low expression of CPS1 (all p < 0.0001).

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MDPI and ACS Style

Ong, K.H.; Hsieh, Y.-Y.; Sun, D.-P.; Huang, S.K.-H.; Tian, Y.-F.; Chou, C.-L.; Shiue, Y.-L.; Joseph, K.; Chang, I.-W. Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296. Diagnostics 2025, 15, 391. https://doi.org/10.3390/diagnostics15030391

AMA Style

Ong KH, Hsieh Y-Y, Sun D-P, Huang SK-H, Tian Y-F, Chou C-L, Shiue Y-L, Joseph K, Chang I-W. Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296. Diagnostics. 2025; 15(3):391. https://doi.org/10.3390/diagnostics15030391

Chicago/Turabian Style

Ong, Khaa Hoo, Yao-Yu Hsieh, Ding-Ping Sun, Steven Kuan-Hua Huang, Yu-Feng Tian, Chia-Lin Chou, Yow-Ling Shiue, Keva Joseph, and I-Wei Chang. 2025. "Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296" Diagnostics 15, no. 3: 391. https://doi.org/10.3390/diagnostics15030391

APA Style

Ong, K. H., Hsieh, Y.-Y., Sun, D.-P., Huang, S. K.-H., Tian, Y.-F., Chou, C.-L., Shiue, Y.-L., Joseph, K., & Chang, I.-W. (2025). Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296. Diagnostics, 15(3), 391. https://doi.org/10.3390/diagnostics15030391

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Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296

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