Prenatal Diagnosis and Clinical Management of Twin Pregnancy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1243

Special Issue Editor


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Guest Editor
Twin Pregnancy Unit, Gynecology and Obstetrics 2U, A.O.U. Città della Salute e della Scienza, Sant’Anna Hospital, University of Turin, 10126 Turin, Italy
Interests: multiple pregnancy; ultrasound; prenatal diagnosis; pregnancy complications; high-risk pregnancy
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Special Issue Information

Dear Colleagues,

The incidence of twin pregnancy is rising, both due to advanced maternal age and to increased use of medically assisted reproduction. Multiple pregnancy is at a high risk for many different complications, both maternal and fetal-neonatal. Ultrasound certainly represents an extremely valuable tool in the diagnosis and management of this kind of pregnancy; also, important advances both in technology and in techniques are constantly made in this field.

In this Special Issue, we encourage authors to contribute with manuscripts which describe the state of the art regarding the diagnosis and management of twin pregnancies and their complications, starting from conception to delivery and neonatal care. Potential topics include, but are not limited to, the following: diagnosis and management of intrauterine growth restriction, monochorionic-related complications, placentation abnormalities, fetal malformations, and preventive methods and clinical management of maternal complications such as preterm birth, gestational hypertensive disorders, gestational diabetes mellitus, and so on.

We look forward to receiving your contributions.

Dr. Silvana Arduino
Guest Editor

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Keywords

  • twin pregnancy
  • ultrasound
  • prenatal diagnosis
  • intrauterine fetal growth restriction
  • monochorionic twins
  • perinatal morbidity
  • maternal complications
  • delivery in twin pregnancy

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Published Papers (1 paper)

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10 pages, 1484 KiB  
Case Report
Monochorionic Diamniotic Twins with Sex Discordance: Case Series
by Valentina Sala, Luigina Spaccini, Stefano Faiola, Daniela Casati, Arianna Laoreti, Lisanne S. A. Tollenaar, Enrico Lopriore and Mariano M. Lanna
Diagnostics 2025, 15(3), 372; https://doi.org/10.3390/diagnostics15030372 - 4 Feb 2025
Viewed by 900
Abstract
Background and Clinical Significance: Ultrasonographic diagnosis of twin pregnancies has become routine, with chorionicity playing a crucial role in assessing associated risks. Traditionally, monochorionic (MC) twins were believed to derive from a single zygote, ensuring sex concordance. However, recent cases of dizygotic monochorionic [...] Read more.
Background and Clinical Significance: Ultrasonographic diagnosis of twin pregnancies has become routine, with chorionicity playing a crucial role in assessing associated risks. Traditionally, monochorionic (MC) twins were believed to derive from a single zygote, ensuring sex concordance. However, recent cases of dizygotic monochorionic (MCDZ) twins challenge this paradigm. In this paper, four cases of MCDZ twins with sex discordance are described. Case presentation: Case 1 and case 2 describe two spontaneous MC/diamniotic twin pregnancies in which sex discordance between twins was attributed to blood chimerism. Case 3 is about a MC/diamniotic twin pregnancy derived from a single blastocyst transfer after in vitro fertilization (IVF), and that was complicated by twin-to-twin transfusion syndrome, with zygosity testing confirming the dizygosity. Case 4 is a twin anemia polycythemia sequence diagnosed after birth in twins considered dichorionic during pregnancy (due to sex difference) and defined as monochorionic after placental examination. Conclusions: The prevalence of monochorionic dizygotic (MCDZ) twins remains uncertain, and many cases likely go unnoticed, particularly when twins are of the same sex. In twin pregnancies, determining chorionicity during the first-trimester ultrasound (US) is critical. Accurate identification of monochorionicity is essential for managing potential complications. Careful verification of sex concordance between twins is necessary. In cases of sex discordance, amniocentesis is required for karyotype evaluation and zygosity testing. Full article
(This article belongs to the Special Issue Prenatal Diagnosis and Clinical Management of Twin Pregnancy)
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