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Diagnostics, Volume 15, Issue 4

2025 February-2 - 113 articles

Cover Story: Metabolic changes during pregnancy affect the blood components critical for diagnosing various pregnancy-related or non-pregnancy-related diseases. Reference values for laboratory parameters in pregnancy differ from those for non-pregnant women, but results are often reported using non-pregnant reference values, potentially leading to misinterpretation, additional diagnostics and unnecessary stress for pregnant women. The primary challenge in establishing reference intervals in pregnancy is the continuous metabolic changes. In addition, reference intervals should be evaluated in terms of their clinical significance for distinguishing physiologic from disease-related changes. The aim of this study is to establish reference values for common laboratory parameters in early pregnancy and to evaluate their clinically significant differences compared to non-pregnant reference intervals. View this paper
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Articles (113)

  • Article
  • Open Access
35 Citations
10,255 Views
12 Pages

Deep Learning-Based Periapical Lesion Detection on Panoramic Radiographs

  • Viktor Szabó,
  • Kaan Orhan,
  • Csaba Dobó-Nagy,
  • Dániel Sándor Veres and ,
  • David Manulis,
  • Matvey Ezhov,
  • Alex Sanders and
  • Bence Tamás Szabó
  • + 3 authors+ 0 author

19 February 2025

Background/Objectives: Our study aimed to determine the accuracy of the artificial intelligence-based Diagnocat system (DC) in detecting periapical lesions (PL) on panoramic radiographs (PRs). Methods: 616 teeth were selected from 357 panoramic radio...

(This article belongs to the Special Issue Advancements in Artificial Intelligence for Dentomaxillofacial Radiology—2nd Edition)
  • Article
  • Open Access
3 Citations
1,732 Views
12 Pages

Exploring Cardiac Sympathetic Denervation in Transthyretin-Mediated Hereditary Amyloidosis (ATTRv): Insights from 123I-mIBG Scintigraphy

  • Maria Silvia De Feo,
  • Chiara Cambieri,
  • Eleonora Galosi,
  • Viviana Frantellizzi and ,
  • Cristina Chimenti,
  • Marco Luigetti,
  • Maria Ausilia Sciarrone,
  • Francesca Graziani,
  • Luca Leonardi and
  • Marco Ceccanti
  • + 15 authors+ 10 authors

19 February 2025

Background/Objectives: Hereditary transthyretin-mediated amyloidosis (ATTRv) is a rare disease characterized by the deposition of amyloid in the heart and peripheral nerves, particularly affecting small fibers. This study aims to evaluate autonomic c...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
4 Citations
4,752 Views
16 Pages

19 February 2025

Interstitial lung abnormalities (ILAs) are incidental radiologic abnormalities on chest computed tomography (CT) examination performed on people in whom interstitial lung disease (ILD) is not suspected. Despite the fact that most of these individuals...

(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)
  • Article
  • Open Access
2 Citations
1,536 Views
11 Pages

Association Between Mandibular Cortical Erosion and Bone Mineral Density Assessed by Phalangeal Ultrasound and Dual Energy X-Ray Absorptiometry in Spanish Women

  • Maria L. Canal-Macías,
  • Vicente Vera-Rodríguez,
  • Olga Leal-Hernández,
  • Julián Fernando Calderón-García and ,
  • Raúl Roncero-Martín,
  • Francisco García-Blázquez,
  • Sergio Rico-Martín,
  • Fidel López-Espuela,
  • José M. Morán and
  • María Pedrera-Canal
  • + 7 authors+ 2 authors

19 February 2025

Background and Objectives: Analysing the characteristics of the mandibular bone through panoramic radiographs could be useful as a prescreening tool for detecting individuals with osteoporosis. The aims of this study were to evaluate the possible ass...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Bone Diseases in 2025)
  • Article
  • Open Access
8 Citations
5,094 Views
17 Pages

19 February 2025

Background/Objectives: Vascular malformations form masses in subcutaneous and muscular tissues throughout the body and are occasionally misdiagnosed as subcutaneous nonvascular tumors. Understanding and differentiating their clinical and imaging feat...

(This article belongs to the Special Issue Ultrasound in the Diagnosis and Management of Skin Diseases)
  • Article
  • Open Access
1 Citations
2,976 Views
12 Pages

Epidemiology of Celiac Disease in Cantabria, Spain

  • Alejandra Blanco-García,
  • Marcos López-Hoyos,
  • Juan Irure-Ventura and
  • Pedro Muñoz-Cacho

19 February 2025

Background/Objectives: Celiac disease is an enteropathy caused by a systemic autoimmune process of genetic predisposition to the ingestion of gluten. It is a public health problem worldwide because there are often long delays between the onset of sym...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
3 Citations
3,113 Views
19 Pages

19 February 2025

Background/Objectives: While gradient-echo (GRE)-based chemical shift-encoded magnetic resonance imaging (CSE-MRI) offers precise method for measuring adiposity in bone marrow, its limitation lies in the need for additional imaging. On the other hand...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
5 Citations
5,564 Views
15 Pages

Trends in Clinical Cardiac Photon-Counting Detector CT Research: A Comprehensive Bibliometric Analysis

  • Arosh S. Perera Molligoda Arachchige,
  • Federica Catapano,
  • Costanza Lisi,
  • Jad El Choueiri and ,
  • Francesca Pellicanò,
  • Stefano Figliozzi,
  • Letterio S. Politi and
  • Marco Francone
  • + 3 authors+ 0 author

19 February 2025

Photon-counting detector computed tomography (PCD-CT) represents a significant advancement in radiological imaging, offering substantial potential for cardiac applications that remain partially underexplored. This bibliometric analysis investigates t...

(This article belongs to the Special Issue Latest Advances and Prospects in Cardiovascular Imaging)
  • Article
  • Open Access
1 Citations
3,221 Views
10 Pages

Comparative Clinical and Histopathological Study of Oral Leukoplakia in Smokers and Non-Smokers

  • Andrei-Eduard Șerban,
  • Ioanina Părlătescu,
  • Elena Milanesi,
  • Iulia Andreea Pelisenco and ,
  • Maria Dobre,
  • Mariana Costache,
  • Șerban Țovaru and
  • Paula Perlea
  • + 3 authors+ 0 author

19 February 2025

Background/Objectives: Oral leukoplakia (OLK) is an oral mucosal lesion classified in the oral potentially malignant disorder group and is associated with an increased risk of malignant transformation (MT). The aim of this study was to compare the cl...

(This article belongs to the Special Issue Advances in Oral Diseases Diagnosis and Management: 2nd Edition)
  • Article
  • Open Access
10 Citations
2,931 Views
34 Pages

19 February 2025

Background: Surgical site infections (SSIs) lead to higher hospital readmission rates and healthcare costs, representing a significant global healthcare burden. Machine learning (ML) has demonstrated potential in predicting SSIs; however, the challen...

(This article belongs to the Special Issue Artificial Intelligence for Clinical Diagnostic Decision Making)
  • Article
  • Open Access
6 Citations
3,291 Views
11 Pages

Role of Cervical Elastography in Predicting Progression to Active Phase in Labor Induction in Term Nulliparous Women

  • Su-Jung Hong,
  • Young-Mi Jung,
  • Jeong-Eun Hwang,
  • Ki-Su Lee and ,
  • Geum-Joon Cho and
  • Min-Jeong Oh
  • + 1 author+ 0 author

19 February 2025

Background/Objectives: Several factors, such as age, parity, body mass index, a favorable cervix, and fetal birth weight, are known to be related to the success of labor induction. With advancements in ultrasound technology, these factors have been s...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
5 Citations
3,802 Views
20 Pages

Confocal Laser Endomicroscopy: Enhancing Intraoperative Decision Making in Neurosurgery

  • Francesco Carbone,
  • Nicola Pio Fochi,
  • Giuseppe Di Perna,
  • Arthur Wagner and ,
  • Jürgen Schlegel,
  • Elena Ranieri,
  • Uwe Spetzger,
  • Daniele Armocida,
  • Fabio Cofano and
  • Antonio Colamaria
  • + 7 authors+ 2 authors

19 February 2025

Brain tumors, both primary and metastatic, represent a significant global health burden due to their high incidence, mortality, and the severe neurological deficits they frequently cause. Gliomas, especially high-grade gliomas (HGGs), rank among the...

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
1,822 Views
9 Pages

Adult Congenital Heart Disease in Serbia: Insights from a Single-Center Registry

  • Aleksandra Nikolić,
  • Stefan Veljković,
  • Jovana Lakčević,
  • Ana Peruničić and ,
  • Armin Šljivo,
  • Miloš Babić,
  • Marko Nikolić,
  • Slobodan Tomić,
  • Dragana Radoičić and
  • Milovan Bojić
  • + 9 authors+ 4 authors

19 February 2025

Background/Objectives: Congenital heart disease (CHD), affecting approximately 1% of live births, has transitioned to a chronic condition due to advances in diagnostics and surgery, resulting in an increasing adult congenital heart disease (ACHD) pop...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Cardiovascular Diseases)
  • Article
  • Open Access
15 Citations
2,785 Views
13 Pages

Performance of Large Language Models ChatGPT and Gemini on Workplace Management Questions in Radiology

  • Patricia Leutz-Schmidt,
  • Viktoria Palm,
  • René Michael Mathy,
  • Martin Grözinger and ,
  • Hans-Ulrich Kauczor,
  • Hyungseok Jang and
  • Sam Sedaghat
  • + 2 authors+ 0 author

19 February 2025

Background/Objectives: Despite the growing popularity of large language models (LLMs), there remains a notable lack of research examining their role in workplace management. This study aimed to address this gap by evaluating the performance of ChatGP...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
15 Citations
5,318 Views
14 Pages

Primary Sinonasal Mucosal Melanoma: A Narrative Review

  • Nikola Todorovic,
  • Petar Djurkovic,
  • Aleksandar Krstic,
  • Nada Tomanovic and ,
  • Pavle Milanovic,
  • Djurdjina Kablar,
  • Zlata Rajkovic Pavlovic,
  • Momir Stevanovic,
  • Jovana Milanovic and
  • Milica Vasiljevic
  • + 9 authors+ 4 authors

18 February 2025

Mucosal melanomas (MMs) are under-researched tumors with a poor prognosis that arise from melanocytes found in the mucous membranes at different anatomical locations throughout the body. MMs are an uncommon yet highly aggressive tumor that typically...

(This article belongs to the Special Issue Challenges Related to the Oral Cavity, Head and Neck: From Diagnosis to Therapy)
  • Case Report
  • Open Access
3,136 Views
8 Pages

Necrotizing Fasciitis of the Forearm in a 20-Week Pregnant Woman: Case Report and Literature Review

  • Andreea Mironică,
  • Bogdan Ioncioaia,
  • Botond Janko,
  • George Călin Dindelegan and ,
  • Alexandru Ilie-Ene,
  • Lucia-Ioana Furcovici,
  • Balazs Sarkadi and
  • Claudiu Ioan Filip
  • + 3 authors+ 0 author

18 February 2025

Background and Clinical Significance: Necrotizing fasciitis (NF) is a rare skin and soft tissue infection that progresses rapidly to necrosis and can be life-threatening. The incidence varies by geographic region but is generally low, with a mortalit...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Review
  • Open Access
12 Citations
5,293 Views
14 Pages

18 February 2025

Fibromyalgia (FM) is a chronic musculoskeletal disease with a higher prevalence among women. To date, there has been no definitive laboratory or imaging assessment for FM, and hence, the diagnosis criteria for FM remained based on subjective assessme...

(This article belongs to the Special Issue Advances in the Laboratory Diagnosis)
  • Article
  • Open Access
5 Citations
4,117 Views
10 Pages

Comparison of the Intraocular Pressure-Lowering Effect of Minimally Invasive Glaucoma Surgery (MIGS) iStent Inject W and Hydrus—The 12-Month Real-Life Data

  • Cedric Weich,
  • Julian Alexander Zimmermann,
  • Jens Julian Storp,
  • Ralph-Laurent Merté and ,
  • Nicole Eter and
  • Viktoria Constanze Brücher
  • + 1 author+ 0 author

18 February 2025

Background/Objectives: To compare the efficacy and safety of Hydrus® Microstent and iStent inject® W implants, in combination with phacoemulsification, for lowering intraocular pressure (IOP) in patients with glaucoma in a real-world clinical...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
11 Citations
2,956 Views
16 Pages

Liquid Biopsy Based Bladder Cancer Diagnostic by Machine Learning

  • Ērika Bitiņa-Barlote,
  • Dmitrijs Bļizņuks,
  • Sanda Siliņa,
  • Mihails Šatcs and ,
  • Egils Vjaters,
  • Vilnis Lietuvietis,
  • Miki Nakazawa-Miklaševiča,
  • Juris Plonis,
  • Edvīns Miklaševičs and
  • Jānis Gardovskis
  • + 6 authors+ 1 author

18 February 2025

Background/Objectives: The timely diagnostics of bladder cancer is still a challenge in clinical settings. The reliability of conventional testing methods does not reach desirable accuracy and sensitivity, and it has an invasive nature. The present s...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
6 Citations
4,149 Views
20 Pages

Diagnostic Performance of an Artificial Intelligence Software for the Evaluation of Bone X-Ray Examinations Referred from the Emergency Department

  • Alejandro Díaz Moreno,
  • Raquel Cano Alonso,
  • Ana Fernández Alfonso,
  • Ana Álvarez Vázquez and ,
  • Javier Carrascoso Arranz,
  • Julia López Alcolea,
  • David García Castellanos,
  • Lucía Sanabria Greciano,
  • Manuel Recio Rodríguez and
  • Vicente Martínez De Vega
  • + 7 authors+ 2 authors

18 February 2025

Background/Objectives: The growing use of artificial intelligence (AI) in musculoskeletal radiographs presents significant potential to improve diagnostic accuracy and optimize clinical workflow. However, assessing its performance in clinical environ...

(This article belongs to the Special Issue Application of Artificial Intelligence in Radiological Imaging Analysis and Diagnosis)
  • Article
  • Open Access
2 Citations
2,038 Views
12 Pages

17 February 2025

Background/Objectives: Cerebrovascular events (CVEs) are a leading cause of intensive care unit (ICU) admissions from the emergency department, often associated with high morbidity and mortality rates. Identifying reliable, non-invasive predictors of...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
3 Citations
3,479 Views
13 Pages

Salivary Cortisol as a Biomarker for Assessing Fear and Anxiety in Patients with Molar–Incisor Hypomineralization

  • Laura-Roxana Contac,
  • Silvia Izabella Pop,
  • Minodora Dobreanu,
  • Madalina Oprica and ,
  • Septimiu Voidazan and
  • Cristina Ioana Bica
  • + 1 author+ 0 author

17 February 2025

Background/Objectives: Molar–incisor hypomineralization (MIH) is a prevalent dental condition characterized by hypomineralized enamel affecting the first permanent molars and incisors. It leads to visible enamel opacities, with varying severity...

(This article belongs to the Special Issue Advances in the Diagnosis of Oral and Maxillofacial Disease: 2nd Edition)
  • Article
  • Open Access
14 Citations
2,543 Views
17 Pages

Transthoracic Lung Ultrasound in Systemic Sclerosis-Associated Interstitial Lung Disease: Capacity to Differentiate Chest Computed-Tomographic Characteristic Patterns

  • Cinzia Rotondo,
  • Giuseppe Busto,
  • Valeria Rella,
  • Raffaele Barile and ,
  • Fabio Cacciapaglia,
  • Marco Fornaro,
  • Florenzo Iannone,
  • Donato Lacedonia,
  • Carla Maria Irene Quarato and
  • Addolorata Corrado
  • + 7 authors+ 2 authors

17 February 2025

Background/Objectives: Even today, interstitial lung disease (ILD) is diagnosed by chest high-resolution computed tomography (lung HR-CT). Large amounts of data are available about the usefulness of transthoracic lung ultrasound (LUS) in ILD. This st...

(This article belongs to the Special Issue Diagnosis, Classification, and Monitoring of Pulmonary Diseases)
  • Article
  • Open Access
6 Citations
1,756 Views
11 Pages

17 February 2025

Background: Radiomics has become a valuable tool in medical imaging, but its clinical use is limited by data variability and a lack of reproducibility between centers. This study aims to assess the differences between two scanners and provide guidanc...

(This article belongs to the Special Issue Recent Advances in Radiomics in Medical Imaging)
  • Article
  • Open Access
1 Citations
5,841 Views
20 Pages

Comparative Study Between Cognitive Phenotypes of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Multiple Sclerosis

  • Mehdi Aoun Sebaiti,
  • Nadia Oubaya,
  • Yannick Gounden,
  • Chloé Samson and ,
  • Emmanuele Lechapt,
  • Abir Wahab,
  • Alain Creange,
  • Mathieu Hainselin and
  • François-Jérôme Authier
  • + 4 authors+ 0 author

17 February 2025

Objective: Cognitive impairments are one of the most common and disabling symptoms associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here, we address the possibility of a specific cognitive profile inherent to ME/CFS. Due t...

(This article belongs to the Special Issue Assessment and Diagnosis of Cognitive Disorders)
  • Article
  • Open Access
10 Citations
4,833 Views
11 Pages

Prevalence and Transfusion Risks of Occult Hepatitis B Infection Among HBcAb-Positive Blood Donors in a High-Endemic Region

  • Ahmed Subeh Alshrari,
  • Shuaibu Abdullahi Hudu,
  • Sa‘adatu Haruna Shinkafi,
  • Albashir Tahir and ,
  • Halima Yunusa Raji and
  • Abdulgafar Olayiwola Jimoh
  • + 1 author+ 0 author

17 February 2025

Background: Hepatitis B virus (HBV) remains a significant global health concern, particularly in sub-Saharan Africa, where endemicity is high. Occult hepatitis B infection (OBI) presents a unique challenge to transfusion safety, as HBV DNA may persis...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Interesting Images
  • Open Access
1 Citations
1,489 Views
5 Pages

Transoral Robotic Approach for Pharyngeal Schwannoma

  • Riccardo Nocini,
  • Valerio Arietti,
  • Sokol Sina and
  • Luca Sacchetto

17 February 2025

Introduction: Schwannomas are a common condition encountered in clinical ENT practice, but they are rarely found in the pharyngeal or laryngeal regions. Materials and Methods: In this report, we share our experience using the transoral robotic approa...

(This article belongs to the Special Issue Diagnosis and Management in Otolaryngology 2026)
  • Article
  • Open Access
5 Citations
1,347 Views
14 Pages

The Impact of the COVID-19 Pandemic on Forensic Psychiatric Examination

  • Daniela Margareta Varga,
  • Florica Voiță-Mekeres,
  • Camelia Liana Buhaș,
  • Gabriel Mihai Mekeres and ,
  • Florina Madălina Mîndru,
  • Nuțu Cristian Voiță and
  • Lavinia Davidescu
  • + 2 authors+ 0 author

17 February 2025

Background/Objectives: Forensic psychiatric expertise significantly contributes to clinical criminology. Interdisciplinary investigations, evaluation tactics, and the use of criminology indices are essential for psychosocial prognostic assessments of...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
2,098 Views
16 Pages

Future Directions in Quantitative SPECT-CT Evaluation of Cardiac Transthyretin Amyloidosis: Correlation with Clinical and Morphological Parameters

  • Mirela Gherghe,
  • Mario-Demian Mutuleanu,
  • Tatiana Lucia Suta,
  • Liliana Micu and ,
  • Adina Elena Stanciu,
  • Sinziana-Octavia Ionescu,
  • Ciprian Cirimbei,
  • Diana Loreta Paun,
  • Andreea Jercan and
  • Daniel Coriu
  • + 6 authors+ 1 author

17 February 2025

Background: ATTRv and ATTRwt cardiac amyloidosis (CA) are underrecognized causes of heart failure with preserved left ventricular ejection fraction. The diagnosis of CA remains challenging due to low diagnostic suspicion and clinical overlap with mor...

(This article belongs to the Special Issue Advances in Cardiovascular Diseases: Diagnosis and Management)
  • Review
  • Open Access
6 Citations
2,204 Views
11 Pages

Congenital Heart Disease After Mid-Age: From the “Grown-Up” to the Elderly

  • Francesca Bonanni,
  • Chiara Servoli,
  • Gaia Spaziani,
  • Elena Bennati and ,
  • Chiara Di Filippo,
  • Giulia Ksenia Cirri,
  • Marzia Giaccardi,
  • Iacopo Olivotto and
  • Silvia Favilli
  • + 4 authors+ 0 author

17 February 2025

Early surgery and improved medical care have led to the increased survival of neonates with congenital heart disease (CHD), who now commonly reach adulthood. Among adults with CHD, a growing subgroup is represented by middle-aged and even elderly pat...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Case Report
  • Open Access
1 Citations
2,406 Views
9 Pages

Klebsiella variicola Infection in a Second Trimester Twin Pregnancy: An Underreported Cause of Chorioamnionitis

  • Maria Paola Bonasoni,
  • Alice Ferretti,
  • Immacolata Blasi,
  • Giuseppina Comitini and ,
  • Lorenzo Aguzzoli,
  • Marcellino Bardaro,
  • Giuseppe Russello and
  • Edoardo Carretto
  • + 3 authors+ 0 author

17 February 2025

Background and Clinical Significance: Klebisella variicola belongs to the Klebsiella pneumoniae complex. It is a Gram-negative, facultative anaerobic, and nonmotile bacillus, mainly isolated in plants. However, as an emerging human pathogen, it...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
13 Citations
4,251 Views
26 Pages

YOLOSAMIC: A Hybrid Approach to Skin Cancer Segmentation with the Segment Anything Model and YOLOv8

  • Sevda Gül,
  • Gökçen Cetinel,
  • Bekir Murat Aydin,
  • Devrim Akgün and
  • Rabia Öztaş Kara

16 February 2025

Background/Objective: The rising global incidence of skin cancer emphasizes the urgent need for reliable and accurate diagnostic tools to aid early intervention. This study introduces YOLOSAMIC (YOLO and SAM in Cancer Imaging), a fully automated segm...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Medical Imaging: 2nd Edition)
  • Review
  • Open Access
8 Citations
6,566 Views
45 Pages

Review of Precision Medicine and Diagnosis of Neonatal Illness

  • Safaa ELMeneza,
  • Naglaa Agaba,
  • Rasha Abd El Samad Fawaz and
  • Salwa Samir Abd Elgawad

16 February 2025

Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people’s genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview...

(This article belongs to the Special Issue Maternal–Fetal and Neonatal Diagnostics)
  • Article
  • Open Access
14 Citations
3,134 Views
26 Pages

A Resting ECG Screening Protocol Improved with Artificial Intelligence for the Early Detection of Cardiovascular Risk in Athletes

  • Luiza Camelia Nechita,
  • Dana Tutunaru,
  • Aurel Nechita,
  • Andreea Elena Voipan and ,
  • Daniel Voipan,
  • Anca Mirela Ionescu,
  • Teodora Simina Drăgoiu and
  • Carmina Liana Musat
  • + 3 authors+ 0 author

16 February 2025

Background/Objectives: This study aimed to evaluate an artificial intelligence (AI)-enhanced electrocardiogram (ECG) screening protocol for improved accuracy, efficiency, and risk stratification across six sports: handball, football, athletics, weigh...

(This article belongs to the Special Issue Advances in Imaging Diagnosis and Management of Cardiovascular and Pulmonary Diseases)
  • Review
  • Open Access
4 Citations
5,425 Views
18 Pages

16 February 2025

Chronic constipation is more common in the elderly and associated with numerous diseases. For the diagnosis of chronic constipation in the elderly, it is essential to exclude constipation secondary to colorectal cancer or other causes. Chronic consti...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
2 Citations
1,332 Views
13 Pages

16 February 2025

Background: It is important to accurately determine the legal age at which a person is considered and treated as an adult; in many countries, it is 18. With the increasing migration flow to European countries, accurate age estimation methods must be...

(This article belongs to the Special Issue New Perspectives in Forensic Diagnosis)
  • Review
  • Open Access
12 Citations
6,165 Views
11 Pages

16 February 2025

Hyperpolarized xenon-129 MRI (129XeMRI) has emerged as a powerful tool in the identification, evaluation, and assessment of disease endotyping and in response to interventions for a myriad of pulmonary diseases. Growing investigative efforts ranging...

(This article belongs to the Special Issue Advances in Imaging Diagnosis and Management of Cardiovascular and Pulmonary Diseases)
  • Brief Report
  • Open Access
1 Citations
1,386 Views
9 Pages

14 February 2025

Objectives: To explore the impact of different standard of truth (SoT) methodologies on efficacy endpoints traditionally used in clinical trials of diagnostic radiopharmaceuticals, using data from the SPOTLIGHT study (NCT04186845) in patients with re...

(This article belongs to the Special Issue Diagnostic Imaging of Prostate Cancer)
  • Interesting Images
  • Open Access
3 Citations
1,925 Views
4 Pages

14 February 2025

We describe the case of a 67-year-old man with lung cancer, who developed pulmonary tuberculosis (TB) following chemotherapy and subsequently exhibited a paradoxical reaction on positron emission tomography/computed tomography (PET/CT) after initiati...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
2,633 Views
45 Pages

Brain Morphometry and Cognitive Features in the Prediction of Irritable Bowel Syndrome

  • Arvid Lundervold,
  • Ben René Bjørsvik,
  • Julie Billing,
  • Birgitte Berentsen and ,
  • Gülen Arslan Lied,
  • Elisabeth K. Steinsvik,
  • Trygve Hausken,
  • Daniela M. Pfabigan and
  • Astri J. Lundervold
  • + 4 authors+ 0 author

14 February 2025

Background/Objectives: Irritable bowel syndrome (IBS) is a gut–brain disorder characterized by abdominal pain, altered bowel habits, and psychological distress. While brain–gut interactions are recognized in IBS pathophysiology, the relat...

(This article belongs to the Special Issue Application of Artificial Intelligence in Gastrointestinal Disease)
  • Article
  • Open Access
10 Citations
3,186 Views
11 Pages

14 February 2025

Background/Objectives: Ultra-Micro Angiography (UMA) is an advanced Doppler technique designed to improve the visualization of slow blood flow in small vessels. The Subtraction UMA (sUMA) setting enhances these features by removing background tissue...

(This article belongs to the Special Issue Diagnosis and Management of Thyroid Disorders)
  • Article
  • Open Access
1 Citations
1,524 Views
12 Pages

14 February 2025

Background/Objectives: Bronchial wash for microbiological cultivation and/or multiplex polymerase chain reaction (PCR) is often routinely performed during bronchoscopy independent of the indication for bronchoscopy. This study aimed to determine and...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
3 Citations
3,200 Views
13 Pages

14 February 2025

Background/Objectives: Continuous monitoring blood culture systems (CMBCSs) are revolutionary automated instruments that facilitate the rapid identification of pathogens in blood samples from patients with sepsis. However, with only a few CMBCSs bein...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
6 Citations
3,694 Views
11 Pages

An Assessment of Deep Learning’s Impact on General Dentists’ Ability to Detect Alveolar Bone Loss in 2D Intraoral Radiographs

  • Amjad AlGhaihab,
  • Antonio J. Moretti,
  • Jonathan Reside,
  • Lyudmila Tuzova and
  • Donald A. Tyndall

14 February 2025

Background/Objective: Deep learning (DL) technology has shown potential in enhancing diagnostic accuracy in dentomaxillofacial radiology, particularly for detecting carious lesions, apical lesions, and periodontal bone loss. However, its effect on ge...

(This article belongs to the Special Issue Advancements in Artificial Intelligence for Dentomaxillofacial Radiology—2nd Edition)
  • Article
  • Open Access
15 Citations
7,182 Views
16 Pages

14 February 2025

Background/Objectives: Endometriosis is a benign condition affecting up to 10% of women at reproductive age. The urinary tract is affected in 0.3–12.0% of women with endometriosis and in 19.0–53.0% of women with deep infiltrating endometr...

(This article belongs to the Special Issue Challenges in Urology: From the Diagnosis to the Management)
  • Review
  • Open Access
6 Citations
4,671 Views
12 Pages

Fetal Hydrops: Genetic Dissection of an Unspecific Sonographic Finding—A Comprehensive Review

  • Gioia Mastromoro,
  • Daniele Guadagnolo,
  • Alessandro De Luca,
  • Mauro Ciro Antonio Rongioletti and
  • Antonio Pizzuti

14 February 2025

Fetal hydrops is defined as the presence of abnormal fluid collections in two or more intra-fetal compartments. It has been classified based on etiology (immune vs. non-immune), on the presence or absence of other findings (isolated vs. non-isolated)...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Case Report
  • Open Access
4,599 Views
10 Pages

Enzyme Replacement Therapy in Mucopolysaccharidosis Type VII: A Three-Year Clinical Outcome Study of the First Taiwanese Case

  • Chung-Lin Lee,
  • Chih-Kuang Chuang,
  • Huei-Ching Chiu,
  • Ya-Hui Chang and ,
  • Yuan-Rong Tu,
  • Yun-Ting Lo,
  • Hsiang-Yu Lin and
  • Shuan-Pei Lin
  • + 3 authors+ 0 author

14 February 2025

Background and Clinical Significance: Mucopolysaccharidosis type VII (MPS VII), an ultrarare lysosomal storage disorder caused by β-glucuronidase deficiency, presents significant therapeutic challenges. Given its extreme rarity and limited treat...

(This article belongs to the Special Issue Rare Diseases: Diagnosis and Management)
  • Article
  • Open Access
1 Citations
1,659 Views
11 Pages

Role of Pelvic Ultrasound in Predicting the Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer

  • Giorgia Perniola,
  • Giulia Paoni Saccone,
  • Noemi Tonti,
  • Federica Tanzi and ,
  • Innocenza Palaia,
  • Violante Di Donato,
  • Federica Tomao,
  • Ludovico Muzii,
  • Giorgio Bogani and
  • Giusi Santangelo
  • + 8 authors+ 3 authors

14 February 2025

Background/Objectives: The optimal treatment for locally advanced cervical cancer (LACC) is debated. The proposed treatments are concomitant chemoradiotherapy plus brachytherapy (cCTRT-B) or neoadjuvant chemotherapy (NACT) followed by radical surgery...

(This article belongs to the Special Issue Imaging for the Diagnosis of Obstetric and Gynecological Diseases)
  • Article
  • Open Access
23 Citations
7,377 Views
22 Pages

13 February 2025

Background/Objective: This study aimed to develop an AI-supported clinical tool to evaluate the difficulty of mandibular third molar extractions based on panoramic radiographs. Methods: A dataset of 2000 panoramic radiographs collected between 2023 a...

(This article belongs to the Special Issue Advancements in Artificial Intelligence for Dentomaxillofacial Radiology)
  • Interesting Images
  • Open Access
1,693 Views
5 Pages

13 February 2025

Ectopic varices account for 5% of variceal bleeding cases but carry high mortality due to their concealed nature and diagnostic challenges. A 46-year-old man with hepatitis C cirrhosis and prior gastroesophageal variceal bleeding presented with fatig...

(This article belongs to the Section Clinical Diagnosis and Prognosis)

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Diagnostics - ISSN 2075-4418