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Diagnostics, Volume 10, Issue 6

June 2020 - 94 articles

Cover Story: Blue light cystoscopy is the most recent breakthrough in the diagnostics of bladder cancer, a common cancer with high rates of recurrence. The photodynamic diagnosis technique uses a photosensitizer as an adjunct to white light cystoscopy to enhance in vivo detection of malignant tissues based on their distinctive fluorescence. Although it has improved detection rates, fluorescence-assisted cystoscopy remains invasive and costly. In parallel, a variety of non-invasive tests and microdevices for the detection of urinary biomarkers of bladder cancer have been developed, none of which have yet entered routine clinical use due to unsatisfactory sensitivity. Following a brief description of the current approaches and their limitations, we provide a systematic review of a new niche research aiming to develop a non-invasive adaptation of photodynamic diagnosis. View this paper.
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Articles (94)

  • Interesting Images
  • Open Access
9 Citations
4,111 Views
7 Pages

The interest of the scientific community for computer aided skin lesion analysis and characterization has been increased during the last years for the growing incidence of melanoma among cancerous pathologies. The detection of melanoma in its early s...

  • Case Report
  • Open Access
23 Citations
4,526 Views
9 Pages

Multifocal Amelanotic Melanoma of the Hard Palate: A Challenging Case

  • Luisa Limongelli,
  • Eliano Cascardi,
  • Saverio Capodiferro,
  • Gianfranco Favia,
  • Massimo Corsalini,
  • Angela Tempesta and
  • Eugenio Maiorano

Among all melanomas, the mucosal type is very rare and may occur in the sino-nasal mucosa, vagina, anus and the oral cavity. At variance with melanomas of the skin, no risk factors, such as familiarity, UV-exposure and skin phenotype, have been clear...

  • Article
  • Open Access
7 Citations
4,570 Views
13 Pages

Mammographic Breast Density and Urbanization: Interactions with BMI, Environmental, Lifestyle, and Other Patient Factors

  • Nick Perry,
  • Sue Moss,
  • Steve Dixon,
  • Sue Milner,
  • Kefah Mokbel,
  • Charlotte Lemech,
  • Hendrik-Tobias Arkenau,
  • Stephen Duffy and
  • Katja Pinker

Mammographic breast density (MBD) is an important imaging biomarker of breast cancer risk, but it has been suggested that increased MBD is not a genuine finding once corrected for age and body mass index (BMI). This study examined the association of...

  • Article
  • Open Access
11 Citations
2,987 Views
9 Pages

Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population

  • Stanislav Pasyk,
  • Nitika Sanger,
  • Flavio Kapczinski and
  • Zainab Samaan

Impulsivity is an important risk factor for suicide and therefore, identifying biomarkers associated with impulsivity could be important in evaluating psychiatric patients. Currently, assessment of impulsivity is based solely on clinical evaluation....

  • Article
  • Open Access
13 Citations
4,157 Views
9 Pages

Carotid Stenosis Assessment with Vector Concentration before and after Stenting

  • Andreas Hjelm Brandt,
  • Tin-Quoc Nguyen,
  • Henrik Gutte,
  • Jonathan Frederik Carlsen,
  • Ramin Moshavegh,
  • Jørgen Arendt Jensen,
  • Michael Bachmann Nielsen and
  • Kristoffer Lindskov Hansen

Digital subtraction angiography (DSA) is considered the reference method for the assessment of carotid artery stenosis; however, the procedure is invasive and accompanied by ionizing radiation. Velocity estimation with duplex ultrasound (DUS) is wide...

  • Article
  • Open Access
51 Citations
4,918 Views
18 Pages

A Supervised Machine Learning Approach to Detect the On/Off State in Parkinson’s Disease Using Wearable Based Gait Signals

  • Satyabrata Aich,
  • Jinyoung Youn,
  • Sabyasachi Chakraborty,
  • Pyari Mohan Pradhan,
  • Jin-han Park,
  • Seongho Park and
  • Jinse Park

Fluctuations in motor symptoms are mostly observed in Parkinson’s disease (PD) patients. This characteristic is inevitable, and can affect the quality of life of the patients. However, it is difficult to collect precise data on the fluctuation...

  • Article
  • Open Access
3 Citations
3,424 Views
14 Pages

Upstroke Time as a Novel Predictor of Mortality in Patients with Chronic Kidney Disease

  • Wen-Hsien Lee,
  • Po-Chao Hsu,
  • Chun-Yuan Chu,
  • Szu-Chia Chen,
  • Ying-Chih Chen,
  • Meng-Kuang Lee,
  • Hung-Hao Lee,
  • Chee-Siong Lee,
  • Hsueh-Wei Yen and
  • Tsung-Hsien Lin
  • + 4 authors

Upstroke time (UT), measured from the foot-to-peak peripheral pulse wave, is a merged parameter used to assess arterial stiffness and target vascular injuries. In this study, we aimed to investigate UT for the prediction of cardiovascular and all-cau...

  • Article
  • Open Access
12 Citations
4,995 Views
17 Pages

Endometriosis is characterized by ectopic endometrial tissue implantation, mostly within the peritoneum, and affects women in their reproductive age. Studies have been done to clarify its etiology, but the precise molecular mechanisms and pathophysio...

  • Article
  • Open Access
270 Citations
31,032 Views
22 Pages

Efficient Pneumonia Detection in Chest Xray Images Using Deep Transfer Learning

  • Mohammad Farukh Hashmi,
  • Satyarth Katiyar,
  • Avinash G Keskar,
  • Neeraj Dhanraj Bokde and
  • Zong Woo Geem

Pneumonia causes the death of around 700,000 children every year and affects 7% of the global population. Chest X-rays are primarily used for the diagnosis of this disease. However, even for a trained radiologist, it is a challenging task to examine...

  • Article
  • Open Access
22 Citations
3,856 Views
15 Pages

The Suitability of FGF21 and FGF23 as New Biomarkers in Endometrial Cancer Patients

  • Aneta Cymbaluk-Płoska,
  • Paula Gargulińska,
  • Anita Chudecka-Głaz,
  • Sebastian Kwiatkowski,
  • Ewa Pius-Sadowska and
  • Bogusław Machaliński

Endometrial cancer is one of the most common cancers of the reproductive organ in women. The incidence of it increases from year to year. In our study we assessed role of FGF21 and FGF23 in the diagnostics of patients with endometrial cancer. The stu...

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Diagnostics - ISSN 2075-4418