Special Issue "Diagnosis of Endometriosis: Biomarkers and Clinical Methods"
Deadline for manuscript submissions: 31 August 2020.
Interests: endometriosis; reproductive immunology; infertility; minimally invasive surgery; in vitro fertilization
Special Issues and Collections in MDPI journals
Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a wide range of symptoms and signs, including acute and chronic pelvic pain and infertility. Endometriosis affects approximately 10% of women in reproductive age, and up to 50% of infertile women. The etiopathogenesis of endometriosis still remains controversial: immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.
One of the main problems for the management of endometriosis is the significant diagnostic delay: to date, several biomarkers are currently being tested in order to provide a reliable non-invasive diagnosis in case of symptoms and signs suspicious for endometriosis.
In addition, ultrasound techniques and magnetic resonance imaging are evolving rapidly, allowing for better accuracy, even with the use of artificial intelligence. Finally, new potential histological makers are helping to correlate the occurrence of endometriosis in different anatomical landmarks, supporting specific pathways to clarify the etiology of the disease.
This Special Issue will publish reviews and original research about the diagnostics of endometriosis: in particular, we welcome articles about molecular, cellular and histological biomarkers; imaging techniques, including ultrasound and magnetic resonance imaging, and new invasive (surgical) techniques.
Dr. Antonio Simone Laganà
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Magnetic resonance imaging
- Invasive diagnosis
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Issues in the pathological diagnostic of atypical endometriosis: a wolf in sheep's clothing?
Authors: Eleftherios Pierre Samartzis1; Stergios Boussios2; Simone Brandt3; Aurelia Noske3
Affiliation: 1) Department of Gynecology and Gynecological Cancer Center, University Hospital Zurich, Frauenklinikstrasse 10, CH-8091, Zurich, Switzerland. 2) Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, ME7 5NY, Gillingham, Kent, UK. 3) Institut Pathologie der Medica, Hottingerstrasse 9 / 11, Postfach, CH-8024, Zurich, Switzerland
Abstract: Endometriosis is a frequent benign gynecologic condition, defined by the presence of ectopic endometrial-like tissue, which affects up to 10% of women in the reproductive age and is often leading to chronic pain disorders and/or infertility. There is an association of endometriosis and the subtypes of clear cell and endometrioid ovarian carcinoma, with an estimated lifetime ovarian cancer risk of about 1,8% for women affected by endometriosis. In certain cases, some tissue areas of endometriosis may be described as “atypical” due to nuclear atypia and polymorphic appearance. However, there is no consistent definition of “atypical endometriosis” in the histologic diagnostic and the term has been used for different lesions in the literature. The lack of uniformity in the histologic definition of “atypical endometriosis” is complicating its use for clinical considerations especially in terms of a possible cancer risk assessment. Even pronounced forms of nuclear atypia may be caused by the persistent inflammatory state in benign endometriosis, as e.g. due to repeated hemorrhage in endometriotic cysts, and the term does in most of the cases not reflect a premalignant condition. This review focusses on the different concepts of “atypical endometriosis”, the pitfalls that may occur in the histological diagnostic, in the communication between pathologists and clinicians, as well as possible future directions in early-diagnostic and cancer prevention in women at risk to develop endometriosis-associated ovarian carcinoma.