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Diagnostics, Volume 10, Issue 7

2020 July - 71 articles

Cover Story: Recently, the incidence of congenital hypothyroidism has increased, especially in preterm infants, who represent a challenge for newborn screening programs. Hypothyroxinemia of prematurity is a major cause of false-positive results on thyroxine (T4)-based screening programs. This study presents T4 reference ranges in dried blood spots and analyzes how T4 concentration changes over time according to gestational age. Our results suggest that in order to improve the efficacy of screening strategies in preterm infants, the use of lower T4 cutoff values according to gestational age at birth may be required. View this paper
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Articles (71)

  • Communication
  • Open Access
2 Citations
3,129 Views
8 Pages

Impact of Chromosome 9 Numerical Imbalances in Oral Squamous Cell Carcinoma: A Pilot Grid-Based Centromere Analysis

  • Efthymios Kyrodimos,
  • Aristeidis Chrysovergis,
  • Nicholas Mastronikolis,
  • Evangelos Tsiambas,
  • Christos Riziotis,
  • Dimitrios Roukas,
  • Panagiotis Fotiades,
  • Chara Stavraka,
  • Vasileios Ragos and
  • Vasileios Papanikolaou
  • + 1 author

Oral squamous cell carcinoma (OSCC) is considered an aggressive malignancy, mainly due to its increased propensity to provide local and distant lymph node metastases. Gross chromosome instability (CI; polysomy/aneuploidy/monosomy), combined or not wi...

  • Article
  • Open Access
17 Citations
3,709 Views
11 Pages

Expression Analysis of Muscle-Specific miRNAs in Plasma-Derived Extracellular Vesicles from Patients with Chronic Obstructive Pulmonary Disease

  • Sara Carpi,
  • Beatrice Polini,
  • Dario Nieri,
  • Nevio Dubbini,
  • Alessandro Celi,
  • Paola Nieri and
  • Tommaso Neri

MicroRNAs (miRNAs) are a class of short non-coding RNAs involved in the regulation of gene expression and the control of several cellular processes at physiological and pathological levels. Furthermore, extracellular vesicles (EV), which are small me...

  • Article
  • Open Access
6 Citations
3,438 Views
10 Pages

Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma

  • David Laville,
  • Francois Casteillo,
  • Violaine Yvorel,
  • Olivier Tiffet,
  • Jean-Michel Vergnon,
  • Michel Péoc’h and
  • Fabien Forest

Bronchial dysplasia is the pre-neoplastic lesion recognized for invasive squamous cell carcinoma. The mechanisms leading to invasive squamous cell carcinoma for this lesion are not fully known. Programmed Death-Ligand 1 (PD-L1) expression by the bron...

  • Review
  • Open Access
6 Citations
4,861 Views
14 Pages

Fibrosis is a life-threatening disorder caused by excessive formation of connective tissue that can affect several critical organs. Innate immune cells are involved in the development of various disorders, including lung fibrosis. To date, several he...

  • Review
  • Open Access
24 Citations
5,183 Views
13 Pages

Radiomics for the Diagnosis and Differentiation of Pancreatic Cystic Lesions

  • Jorge D. Machicado,
  • Eugene J. Koay and
  • Somashekar G. Krishna

Radiomics, also known as quantitative imaging or texture analysis, involves extracting a large number of features traditionally unmeasured in conventional radiological cross-sectional images and converting them into mathematical models. This review d...

  • Article
  • Open Access
8 Citations
3,683 Views
11 Pages

Impact of Breast Density Awareness on Knowledge about Breast Cancer Risk Factors and the Self-Perceived Risk of Breast Cancer

  • Kristina Bojanic,
  • Sonja Vukadin,
  • Filip Sarcevic,
  • Luka Malenica,
  • Kaja Grgic,
  • Robert Smolic,
  • Kristina Kralik,
  • Ines Bilic Curcic,
  • Gordana Ivanac and
  • Martina Smolic
  • + 1 author

Breast density (BD) reduces sensitivity of mammography, and is a strong risk factor for breast cancer (BC). Data about women’s awareness and knowledge of BD are limited. Our aim is to examine whether the BD information disclosure and BD awarene...

  • Article
  • Open Access
38 Citations
4,414 Views
13 Pages

Corneal In Vivo Laser-Scanning Confocal Microscopy Findings in Dry Eye Patients with Sjögren’s Syndrome

  • Yukihiro Matsumoto,
  • Osama M. A. Ibrahim,
  • Takashi Kojima,
  • Murat Dogru,
  • Jun Shimazaki and
  • Kazuo Tsubota

Purpose: To evaluate the changes in cornea in Sjögren’s syndrome (SS) with a novel confocal microscopy device. Methods: Twenty-three right eyes of patients with SS (23 women; mean age, 65.4 ± 11.4 years) and 13 right eyes of 13 age-...

  • Interesting Images
  • Open Access
8 Citations
4,954 Views
5 Pages

COVID-19 Pneumonia: Three Thoracic Complications in the Same Patient

  • Andrea Borghesi,
  • Carlo Aggiusti,
  • Davide Farina,
  • Roberto Maroldi and
  • Maria Lorenza Muiesan

The most dreaded thoracic complications in patients with coronavirus disease 2019 (COVID-19) are acute pulmonary embolism and pulmonary fibrosis. Both the complications are associated with an increased risk of morbidity and mortality. While acute pul...

  • Article
  • Open Access
4 Citations
2,883 Views
7 Pages

Estimation of Cadaveric Age by Ultrasonography

  • Hiroaki Ichioka,
  • Daisuke Miyamori,
  • Noboru Ishikawa,
  • Risa Bandou,
  • Nozomi Idota,
  • Hiroki Kondou and
  • Hiroshi Ikegaya

(1) Background: While decreasing bone mineral density (BMD) with age in living people has been well documented, a correlation between age and bone mineral density in deceased people has only been reported in a few studies. A correlation between age a...

  • Review
  • Open Access
22 Citations
4,245 Views
12 Pages

Patient-specific rehearsal (PsR) is a new concept whereby a procedure can be rehearsed virtually using the exact patient’s anatomical data prior to performing the real procedure. The aim of this study was to ascertain if endovascular virtual-re...

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Diagnostics - ISSN 2075-4418